Neuroanatomy Flashcards
- CNS - Blood supply
- Internal carotid system (from internal carotid a.)
- Opthalmic a.
- ant. + middle cerebral a.
- inf. + sup. hypophyseal a.
- ant. choroid a.
- post. communicating a.
- Vertebrabasilar system (from vertebral + basilar a.)
- ant. + post. spinal a.
- post. inf. cerebellar a.
- basilar a.
1.1 CNS - Blood supply - Circle of Willis
→ anastomosis of int. cartotid a. and vertebral a.
→ located in subarachnoid space
- ant. + post. cerebral arteries
- ant. + post. communicating arteries
- internal carotid artery
- Basilar artery
1.2 CNS - Blood supply - Veins
- cerebral vein
- inferior
- middle
- superior
- great
- internal
- basal vein
1.3 CNS - Dural venous sinuses
- between the 2 layers of cranial dura mater
- Unpaired
- sup. + inf. sagittal
- straight
- occipital
- Paired
- sphenoparietal
- cavernous
- sup. + inf. petrosal
- transverse
- sigmoid
1.4 Blood brain barrier
- separates blood and CSF in the CNS
- because of tight junctions between endothelial cells
- layers:
- Choroidal endothelial cells: tight junctions
- Basement membrane
- Ependymal cells: tight junctions
- substances may cross via
- active transport
- diffusion
- facilitated diffusion
- Meninges - Anatomy
- surrounds brain with 3 layers
- dura mater
- strong, thick, fibrous
- periosteal layer
- meningeal layer
- strong, thick, fibrous
- arachnoid membrane
- delicate nonvascular CT membrane
- allows one way flow of CSF to venous circulation
- pia mater
- delicate vascular CT membrane
- covers surface of brain
- dura mater
2.1 Meninges - Blood supply
- meningeal art.
- anterior
- middle
- posterior
2.2 Meninges - Innervation
→ rich nerve supply, because of vasoconstriction
- Trigeminal nerve (CN 5)
- Vagus nerve (CN 10)
- Hypoglossal nerve (CN 12)
2.3 Meninges - Subarachnoid space
- space between:
- arachnoid membrane + dura mater
- contains CSF and arteries
- surrounds CNS → enlarges at times
- → subarachnoid cisternae
- Brain ventricles
lateral + 3rd ventricle
-
Lateral ventricles
- located within cerebral hemispheres
- connected to 3rd ventricle via the interventricular foramina
- consists of:
- body
- frontal horn
- temporal horn
- occipital horn
- atrium
-
3rd ventricle
- between the two thalami
- filled with CSF
- connected to 4th ventricle via cerebral aqueduct
- has recesses:
- optic recess
- infundibular recess
- pineal recess
- suprapineal recess
3.1 Brain ventricles
4th ventricle
- posterior to brainstem
- anterior to cerebellum
- communicates with
- 3rd ventricle via cerebral aqueduct
- spinal cord via central canal
- contains a pair of choroid plexi
- site of CSF production
- Borders:
- superior: sup. + inf. medullary veli
- inferior: rhomboid fossa
- lateral: cerebellar peduncles
3.2 Choroid plexus
- 4 cisterns, one in each ventricle
- produce CSF
- modified ependymal cells
- 500ml/day
- total volume: 140 ml
- supports + cushions CNS
- transports hormones
- removes waste products
-
Circulation
- lateral ventricles
- 3rd ventricle
- 4th ventricle
- cerebellomedullary cistern
- subarachnoid space
- reabsorbtion into dural sinuses
- cerebellomedullary cistern
- 4th ventricle
- 3rd ventricle
- lateral ventricles
3.3 Subarachnoid cisterns
→ expanded areas of subarachnoid space, also filled w/ CSF
- between arachnoid and pia mater
- Cerebello•medullary cistern
- Basal cistern
- Ponto•cerebellar cistern
- Interpeduncular cistern
- carotic cistern
- lumbar cistern
- Cervival plexus
Muscular branches
- formed by rami of C1-C4
-
Muscular branches
- Ansa cervicalis (C1-C3, CN12)
- Genio•hyoid
- Thyro•hyoid
- Sterno•hyoid
- Omo•hyoid
- Phrenic nerve (C4)
- Diaphragm
- Pericardium
- Segmental branches (C1-C4)
- ant. + mid. scalenus m.
- suboccipital m.
- Ansa cervicalis (C1-C3, CN12)
4.1 Cervical plexus
Cutaneous branches
- lesser occipital n.
- greater auricular n.
- transverse cervival n.
- supraclavicular n.
- Brachial plexus
- from rami C5-C8 + T1
- “M A R M U”
- Lumbar plexus
- formed by rami of L1-L4 + T12 (subcostal n.)
- Branches
- iliohypogastric
- ilioinguinal
- genitofemoral
- lat. femoral cutaneous
- obturator
- femoral
- muscular branches
- Sacral plexus
- formed by rami of L4-L5 + S1-S4
-
Sciatic plexus
- sup. + inf. gluteal n.
- post. femoral cutaneous n.
- sciatic n.
- tibial n.
- common peroneal n.
-
Pudendal (hemorrhoidal) plexus
- Pudendal nerve
- Pelvic splanchnic nerve
- sympathetic PNS - Anatomy and peripheral ganglia
- larger part of autonomic NS
- neurotransmitter: mainly ACh + NE
- induces fight-or-flight response
- 2 different kinds:
-
Paravertebral ganglia
- Cervical g. (3)
- Thoracic g. (11)
- Lumbar g. (5)
-
Prevertebral ganglia
- Celiac g.
- sup. + inf. Mesenteric g.
8.1 sympathetic PNS - Plexuses
- Cavernous p.
- Carotid p.
- Cardiac p.
- Pulmonary p. (ant. + post.)
- Celiac p.
- sup. + inf. Mesenteric p.
- inf. Hypogastric p.
8.2 sympathetic PNS - Nerves
- Cardiopulmonary n.
- Thoracic splanchnic nerves
- greater -
- lesser -
- least -
- Lumbar splanchnic n.
- parasympathetic PNS - peripheral ganglia
- part of autonomic NS
- neurotransmitter: only ACh
- induces rest-and-digest action
-
Head and neck ganglia
- Ciliary g.
- Pterygopalatine g.
- Submandibular g.
- Otic g.
-
Intramural ganglia
- from vagus nerve
9.1 parasympathetic PNS - Plexuses
- very similar to sympathetic plexuses!
- Cardiac p.
- Pulmonary p.
- Celiac p.
- sup. + inf. Mesenteric p.
- inf. Hypogastric p.
9.2 parasympathetic PNS - Nerves
- Occulomotor n. (CN 3)
- Facial n. (CN 7)
- Glossopharyngeal n. (CN 9)
- Vagus n. (CN 10)
- Pelvic splanchnic n. (S2-S4)
- from pudendohemorroidal plexus
- Spinal cord - Gross anatomy
- cylindrical portion of the CNS
- found in vertebral canal
- borders
- cranially: foramen magnum
- caudally: L2 vertebra
-
Anterior:
- anterior median fissure
- anterior spinal art.
- antero•lateral sulcus
- exit of anterior spinal nerve roots
- anterior median fissure
-
Posterior:
- postero•lateral sulcus
- entrance of posterior spinal nerve roots
- posterior median sulcus
- dividing spinal cord into two symmetrical halfs
- posterior intermediate sulcus
- postero•lateral sulcus
10.1 Spinal cord - External features
- Enlargements
- cervical
- lumbar (L4-L5 = thickest)
- conus medullaris
- level of L2
- cauda equina
- spinal nerve roots L1 + L2
- filum terminale
- attaches conus medullaris to coccyx
10.2 Spinal cord - Crosssection
- grey matter (inside part)
- anterior-, lateral-, posterior column
- white matter (outside part)
- anterior-, lateral-, posterior funiculus
- cervical + lumbar part is bigger in diameter
- due to lumbar + sacral plexus
10.3 Spinal cord - Meninges
- consists of 3 layers
-
pia mater
- Denticulate lig.
- attach arachnoid- + dura mater
- subarachnoid space w/ cerebrospinal fluid
- Denticulate lig.
-
arachnoid mater
- forms perineurum of spinal nerves
-
dura mater
- makes up:
- cauda equina
- filum terminale
- makes up:
-
pia mater
- further enclosed by:
- meningeal layer of spinal dura
- epidural space w/ fat tissue + vertebral venous plexus
- periosteal layer of spinal dura
- continous with cranial meninges at foramen magnum!
10.4 Spinal cord - Blood supply
Arteries
-
vertebral (longitudinal) art.
- ant. + post. spinal art.
- arterial anastomoses: arterial vasocorona
-
segmental (radicular) art.
- pass through intervertebral foramen
- ant. + post. radicular art.
- have anastomoses
- dominant artery: Art. of Adamkiewicz
Veins (like arteries)
- ant. + post. spinal veins
- ant. + post. radicular veins
- internal vertebral plexus in the epidural space
- which drains into: external vertebral plexus
- finally: intervertebral veins
10.5 Spinal cord segment
- anatomical + functional unit of the spinal cord
- consists of:
- gray matter
- central canal
- contains cerebrospinal fluid
- central canal
- white matter (columns)
- grey matter (horns)
- gray matter
- contents:
- one pair of spinal nerves
- dorsal + ventral roots
- dorsal root ganglion
- sensory + motor neurons
- Spinal cord - White matter
- contains:
- nerves
- glial cells
- blood vessels
- Nerve fibres with similar destinations:
- Tracts/Pathways - in funiculi!
- ascending
- descending
- intersegmental
- Tracts/Pathways - in funiculi!
11.1 Spinal cord - White matter - Ascending tracts
- PERIPHERY → SPINAL CORD → BRAINSTEM → THALAMUS → CORTEX
- may be crossed or uncrossed
- in ant. white commissure (post. to ant. median fissure)
- axons of a lower segmental origin lie more superficial
- “Somatotopy”, Kahler’s law
11.2 Spinal cord - White matter - Ascending tracts
Antero-lateral funiculus
- Ant. + lat. spinothalamic tract
- Ant. + post. spinocerebellar tract
Posterior funiculus
- fasciculus gracilis (medial)
- fasciculus cuneatus (lateral)
11.3 Spinal cord - White matter - Descending tracts
- CORTEX → BRAINSTEM → SPINAL CORD → PERIPHERY
- found more in the “anterior part” of the spinal segment
11.4 Spinal cord - White matter - Descending tracts
Anterior funiculus
- Ant. corticospinal tract
- Olivospinal tract
- Vestibulospinal tract
- Reticulospinal tract
Lateral funiculus
- Lat. corticospinal tract
- Rubrospinal tract
- Spinal cord - Grey matter - Structure
- forms H-shape within white matter
-
anterior column
- ant. horn
- mainly motor neurons
- alpha- + gamma-motor neurons
-
lateral column
- lat. horn
- mainly autonomic neurons
- sympathetic + parasympathetic ganglia
-
posterior column
- post. horn
- mainly sensory neurons
- substantia gelatinosa
- nucleus dorsalis
-
anterior column
12.1 Spinal cord - Grey matter - Rexed laminae
- separates neurons from each other
- 10 layers to organize grey matter
- discovered by Bror Rexed in 1950s
- there are several motor neuron groups (lamina IX)
12.2 Spinal cord - Grey matter - Nuclei
- Intermedio•lateral nucleus (lamina VII)
- Intermedio•medial nucleus (lamina VII)
- contains interneurons
- Dorsal-/Clarke nucleus (lamina VII)
- Nucleus proprius (laminae III, IV)
- Substantia gelatinosa (lamina II)
- Marginal nucleus (lamina I)
- Motor neurons (laminae IX)
- alpha neurons: extrafusal muscles (striated)
- gamma neurons: intrafusal
12.2 Spinal cord - Grey matter - Transmitters
- Glutamate
- Glycine
- ACh
- Brainstem - General information
- consists of:
- medulla
- pons
- midbrain
- can be seen only when brain is removed
- covered by cerebral hemispheres!
- extends from:
- inferior: pyramidal decussation to
- superior: posterior comissure
- two white nerve crossings
13.1 Medulla Oblongata/Myelencephalon - Structure
- most inferior part of brainstem
- pyramidal decussation to inf. pontine sulcus
- anterior parts are called “pyramids”
- contain motor fibers: “pyramidal tracts”
- contains autonomic centers regulating:
- respiration, circulation, GI motility
- gives rise to CN 9-12
- connected to the cerebellum by the inf. cerebellar peduncle