Neuro: Sedantes e hipnóticos Flashcards

1
Q

Mecanismo de acción de las benzodiacepinas

A

Moduladores alostéricos de receptores GABA-A

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2
Q

Efectos farmacológicos de las benzodiacepinas (4)

A

Sedantes
Hipnótico
Ansiolítico
Anticonvulsivo

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3
Q

Efectos adversos de las benzodiacepinas

A

Somnolencia
Mareo
Fatiga
Incoordinación
Amnesia

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4
Q

Síndrome de abstinencia por benzodiacepinas

A

Ansiedad
Insomnio
Convulsiones

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5
Q

No se deben usar benzodiacepinas en pacientes que tomen…

A

Depresores del SNC (alcohol u opioides).

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6
Q

El antagonista de las benzodiacepinas es el…

A

Flumazenil

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7
Q

Mecanismo de acción del zolpidem

A

Modula el receptor de GABA en su sitio omega-1.

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8
Q

Indicación de uso de zolpidem

A

Insomnio

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9
Q

Interacción peligrosa con zolpidem

A

GHB (oxibato de sodio), usualmente ilegal.

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10
Q

Efectos adversos del zolpidem

A

Mareos
Cefalea
Somnolencia

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11
Q

Benzodiacepinas de uso común

A

Alprazolam
Midazolam
Clonazepam
Diazepam

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12
Q

Mecanismo de acción del fenobarbital (barbitúrico)

A

Modulador alostérico de GABA A.
Aumento de tiempo de apertura del canal.
Antagonismo glutamatérgico

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13
Q

Indicaciones del uso de fenobarbital

A

Estado epiléptico
Crisis epilépticas

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14
Q

Efecto adverso grave de los barbitúricos

A

Depresión respiratoria

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15
Q

El flumazeni es un…

A

Antagonista competitivo de los receptores de benzodiacepinas

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16
Q

Un efecto adverso grave del flumazenil es….

A

Inducir crisis epilépticas