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Adult Neuro > Neuro Review Table - Dementias (1) > Flashcards

Neuro Review Table - Dementias (1) Flashcards

1
Q

LBD

A

Synucleinopathy (Lewy bodies throughout cortex)

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2
Q

AD

A

Tauopathy (neuritic plaques + neurofibrillary tangles)

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3
Q

PD

A

Synucleinopathy (Lewy bodies in neurons)

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4
Q

MSA

A

Synucleinopathy (Lewy bodies in glial cells)

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5
Q

CBD

A

Tauopathy (ballooned hypochromatic cortical neurons)

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6
Q

PSP

A

Tauopathy (globose neurofibrillary tangles in brainstem nuclei)

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7
Q

FTLD (behavioral)

A

tauopathy; aka Pick disease; personality change

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8
Q

FTLD (primary progressive aphasia)

A

expressive aphasia –> global aphasia

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9
Q

FTLD (temporal/semantic aphasia)

A

receptive aphasia –>

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10
Q

Huntington

A

CAG repeat in huntingtin gene (Chr 4)

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11
Q

LBD hypometabolism?

A

occipital

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12
Q

AD hypometabolism?

A

posterior temporo-parietal

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13
Q

PD hypometabolism?

A

BG

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14
Q

CBD hypometabolism?

A

asymmetric frontoparietal

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15
Q

FTLD (PPA) hypometabolism?

A

L frontal + temporal

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16
Q

FTLD (temp) hypometabolism?

A

R ant temporal

17
Q

Huntington hypometabolism

A

head of caudate

18
Q

PSP hypometabolism?

A

global metabolic reduction

NeuroPrep:medial frontal + insula + head caudate

19
Q

APP gene

A

AD1 mutation (chromosome 21), beta-amyloid protein, 2% familial AD

20
Q

Presenilin 1

A

PS1 mutation (chr. 14), gamma secretase catalytic subunits, 75% familial AD

21
Q

Presenilin 2

A

PS2 mutation (chr. 1)

22
Q

Tau gene haplotype H1

A

AD; Chromosome 17, assoc w PSP, CBD and FTDP-17 variant (FTLD w parkinsonian features)

23
Q

Tau gene haplotype H2

A

AD; Chromosome 17, assoc w semantic/temporal variant of FTLD

24
Q

Primary pathology in FTLD?

A

tau-positive intracytoplasmic inclusions (Pick bodies)

Adult Neuro (4 decks)

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