Neuro Physiology and Anatomy Flashcards

1
Q

Hyperopia (farsighted)

A

Eye cannot focus on nearby objects because light focuses behind the retina (due to shortness of the eye or an inability of the lens to become convex)

Tx: convex lens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Myopia (nearsighted)

A

Eye cannot focus on distant objects because light focuses in front of the retina (due to length of the eye or an inability of the lens to flatten out)

Tx: biconcave lens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Astigmatism

A

Abnormal curvature of cornea, resulting in different refractive power at different axes

Tx: cylindric lens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Presbyopia

A

Decrease in focusing ability during accommodation due to sclerosis and decreased elasticity; often age-related. The “near point” (closest point on which one can focus by accommodation of the lens) moves farther from the eye

Tx: convex lens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

CN III damage

A

Affects eye movement (SR, IR, MR, IO), pupillary constriction (sphincter pupillae), accommodation (ciliary muscle), eyelid opening (levator palpebrae)

Causes “down and out” eye, pupillary dilation, loss of accommodation, and ptosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

CN IV damage

A

Affects SO; eye looks upward with adduction

Head tilt toward the side of the lesion / the unaffected eye

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

CN VI damage

A

Affects LR; eye looks medially

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Lesion in somatosensory cortex

A

Contralateral sensory deficit; may be associated with UPN-type weakness, visual field deficits, and aphasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Lesion in VPL

A

Contralateral sensory deficit; larger deficits may involve the internal capsule (hemiparesis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Lesion in the lateral pons or lateral medulla

A

Affects the anterolateral pathways and spinal trigeminal nucleus

Contralateral loss of pain and T sensation in the body, and Ipsilateral loss of pain and T sensation in the face

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Lesion in the medial medulla

A

Affects the medial lemniscus

Contralateral loss of vibration and joint position sense

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Lateral hypothalamus

A

Produces orexin (hypocretin), which stimulates hunger and wakefulness. Inhibited by leptin.

Destruction causes anorexia or failure to thrive in infants, and narcolepsy (due to decreased orexin/hypocretin production).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Ventromedial hypothalamus

A

Controls satiety. Stimulated by leptin. Destruction (e.g. craniopharyngioma) causes hyperphagia and aggressive, savage behavior.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Anterior hypothalamus

A

Lowers T via PSNS. Stimulated by increased heat.
Location of osmoreceptors (controls ADH release)

“A/C” of the hypothalamus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Posterior hypothalamus

A

Increases T via sympathetics. Stimulated by decreased heat.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Suprachiasmatic nucleus of the hypothalamus

A

Responsible for circadian rhythm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Supraoptic nucleus of hypothalamus

A

Produces ADH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Paraventricular nucleus of hypothalamus

A

Produces oxytocin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Ventroposteriolateral (VPL) nucleus of the thalamus

A

Pressure, touch, vibration and proprioception (from the dorsal columns/medial lemniscus); pain and T (from the spinothalamic)

Projects to primary somatosensory cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Ventroposteriomedial (VPM) nucleus of the thalamus

A

Face sensation and taste from the trigeminal and gustatory pathway (via the solitary nucleus)

Projects to primary somatosensory cortex

“Make-up goes on the face”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Lateral geniculate nucleus (LGN) of the thalamus

A

Vision via CN II

Projects to calcarine sulcus (primary visual cortex)

“L = Light”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Medial geniculate nucleus (MGN) of the thalamus

A

Hearing via superior olive and inferior colliculus of tectum

Projects to auditory cortex of temporal lobe

“M=Music”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Ventrolateral (VL) nucleus of the thalamus

A

Motor via basal ganglia and cerebellum

Projects to motor cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Deep nuclei of cerebellum (lateral –> medial)

A

Lateral to medial: Dentate, Emboliform, Globose, Fastigial

“Don’t Eat Greasy Foods”

25
Q

Lesion of lateral cerebellum

A

Affects voluntary movement of extremities. Intention tremor.

Fall toward injured (ipsilateral) side

26
Q

Lesion of medial cerebellum

A

Truncal ataxia, nystagmus, head tilting, wide-based (cerebellar gait), deficits in truncal coordination, dysarthria

Midline lesions usually result in bilateral motor deficits affecting axial and proximal limb musculature.

27
Q

Lesion of globus pallidus

A

Inability to maintain postural support

28
Q

Lesion of subthalamic nucleus

A

Contralateral hemiballismus

29
Q

Lesion of striatum

A

Huntington’s disease (atrophy of caudate nucleus)

30
Q

Lesion of substantia nigra

A

Parkinson’s disease

31
Q

Kluver-Bucy syndrome

A

Caused by damage to bilateral amygdalas (associated with HSV-1)

Causes hyperorality, hypersexuality, disinhibited behavior

32
Q

Lesion of right parietal-temporal cortex

A

Spatial neglect syndrome (agnosia of contralateral side of world)

33
Q

Lesion of left parietal-temporal cortex

A

Agraphia, acalculia, finger agnosia, and left-right disorientation

34
Q

Wernicke-Korsakoff syndrome

A

Damage to bilateral mammilary bodies due to thiamine (B1) deficiency; can be precipitated by giving glucose without B1 to a B1-deficient patient

Wernicke: confusion, ataxia, nystagmus
Korsakoff: memory loss, confabulation, personality changes

35
Q

Lesion to paramedian pontine reticular formation

A

Eyes look away from side of lesion. Loss of horizontal saccades towards side of lesion

36
Q

Lesion to frontal eye fields

A

Eyes look toward lesion. Normally, stimulation of frontal eye fields cause conjugate gaze contralateral to the stimulation

37
Q

Stroke of anterior spinal artery

A

Medial medullary syndrome. Stroke commonly bilateral.

  • Contralateral hemiparesis (lateral corticospinal tract)
  • Decreased contralateral proprioception (medial lemniscus)
  • Ipsilateral hypoglossal dysfunction (caudal medulla)
38
Q

Stroke of posterior inferior cerebellar artery (PICA)

A

Lateral medullary (Wallenberg) syndrome

  • Vomiting, vertigo, and nystagmus (vestibular nuclei)
  • Decreased pain and T sensation from ipsilateral face and contralateral body (lateral spinothalamic tract, spinal trigeminal nucleus)
  • Dysphagia, hoarseness, and decreased gag reflex (nucleus ambiguus)
  • Ipsilateral Horner syndrome (sympathetic fibers)
  • Ataxia, dysmetria (inferior cerebellar peduncle)
39
Q

Stroke of anterior inferior cerebellar artery (AICA)

A

Lateral pontine syndrome

  • Vomiting, vertigo, and nystagmus (vestibular nuclei)
  • Paralysis of face, decreased lacrimation and salivation, decreased taste from anterior 2/3 of tongue, decreased corneal reflex (facial nucleus)
  • Ipsilateral hearing deficit (cochlear nuclei)
  • Ipsilateral Horner syndrome (sympathetic fibers)
  • Ataxia, dysmetria (middle and inferior cerebellar peduncles)
40
Q

Stroke of basilar artery

A

Produces “locked-in” syndrome

41
Q

Lesion of anterior communicating artery

A

Common site of saccular (berry) aneurysm

Produces visual field deficits

42
Q

Lesion of posterior communicating artery

A

Common site of saccular (berry) aneurysm

Produces CN3 palsy

43
Q

Clinical reflexes

A

S1, 2 - “buckle my shoe” (Achilles reflex)
L3, 4 - “kick the door” (patellar reflex)
C5, 6 - “pick up sticks” (biceps reflex)
C7, 8 - “lay them straight” (triceps reflex)

L1, L2 - “testicles move” (cremaster reflex)
S3, S4 - “winks galore” (anal wink reflex)

44
Q

Corneal reflex

A

V1 ophthalmic (nasociliary branch) –> VII (temporal branch: orbicularis oculi)

45
Q

Lacrimation reflex

A

V1 ophthalmic –> VII (temporal branch)

46
Q

Jaw jerk reflex

A

V3 (sensory, muscle spindle from masseter) –> V3 (motor, masseter)

47
Q

Pupillary reflex

A

II –> III

48
Q

Gag reflex

A

IX –> X

49
Q

Structures transversing cribiform plate

A

CN I olfactory bundles

50
Q

Structures transversing optic canal

A

CN II, opthalmic artery, central retinal vein

51
Q

Structures transversing superior orbital fissure

A

CN III, IV, V(1), VI; opthalmic vein, sympathetic fibers

52
Q

Structures transversing foramen rotundum

A

CN V(2) - maxillary branch

53
Q

Structures transversing foramen ovale

A

CN V(3) - mandibular branch

54
Q

Structures transversing foramen spinosum

A

Middle meningeal artery and vein

55
Q

Structures transversing internal acoustic meatus

A

CN VII, VIII

56
Q

Structures transversing jugular foramen

A

CN IX, X, XI, jugular vein

57
Q

Structures transversing hypoglossal canal

A

CN XII

58
Q

Structures transversing foramen magnum

A

Spinal roots of CN XI, brain stem, vertebral arteries