Neuro-pharmacology: Movement/PD

Question 1

Two MAO-B inhibitors

Answer 1

Selegiline (eldepryl), Rasagaline (azilect)

Question 2

4 dopamine agonists

Answer 2

pramipexole, ropinirole, bromocriptine, pergolide

Question 3

COMT inhibitor both at brain and periphery

Answer 3

tolcapone (entacapone onle peripheral COMT)

Question 4

Dopamine agonists carry a risk for what type of psych disorder

Answer 4

impulse control (gambling, shopping, hypersexuality

Question 5

Purpose of MAO-B inhibitors in PD

Answer 5

produce greater peak effect of levodopa and reduce on-off phenomenon

Question 6

Never take MAO-B inhibitors with what 3 types of drugs

Answer 6

TCAs, SSRIs, dextromethorphan

Question 7

Major adverse effect with tolcapone

Answer 7

hepatotoxicity

Question 8

Drug to help with advanced PD/dyskinesias, unclear mechanism can cause livedo reticularis

Answer 8

amantadine

Question 9

3 drugs for PD related agitation (less D2 affinity)

Answer 9

clozapine, quetiapine pimavanserin (5-HT2a)

Question 10

3 treatments for hyperkinetic disorders

Answer 10

trihexyphenidyl, benztropine, tetrabenazine

Question 11

MOA: trihexyphenidyl and benztropine

Answer 11

anticholinergic

Question 12

MOA: tetra benazine

Answer 12

VMAT2 inhibitor