Neuro- Other conditions

Question 1

A 4 year old boy has developmental delay, and 6 individual, 4cm oval pigmented lesions on his trunk and has freckles in both of his axillae. What is the most likely diagnosis?

Answer 1

Neurofibromatosis Type 1

Question 2

Name 3 signs/ symptoms of neurofibromatosis type 1.

Answer 2

Cafe au lait spots
Axillary/ groin freckles
Scoliosis
Lisch nodules (Iris hamartomas)
Phaeochromocytoma

Question 3

What is the first line treatment for neuropathic pain?

Answer 3

Amitryptiline
Duloxetine
Pregabalin
Gabapentin

Question 4

Which chromosome is affected in Huntington’s disease?

Answer 4

Chromosome 4

Question 5

Which amino acids are repeated in the trinucleotide repeat expansion of Huntington’s disease?

Answer 5

Cytosine
Adenine
Guanine

Question 6

What are the main symptoms of Huntington’s disease?

Answer 6

Chorea
Psychiatric problems
Dementia

Question 7

Procyclidine is an __________ drug used in the treatment of:
Drug induced parkinsonism
Dystonia
Akathisia

Answer 7

Anticholinergic

Question 8

Pyridostigmine is an acetylcholinesterase inhibitor used to treat __________

Answer 8

Myasthenia Gravis

Question 9

Lambert Eaton Syndrome is associated with which cancer?

Answer 9

Small cell lung cancer

Question 10

Compare how myasthenia gravis and Lambert Eaton affect patients in terms of:
Which part of NMJ affected
Reflexes
Muscles affected
How activity impacts

Answer 10

Myasthenia: Post synaptic NAchR, worse with activity, occular and bulbar, reflexes normal

Lambert: Pre synaptic calcium channels, better with activity, occular and bulbar rarely affected, hyporeflexia