Neuro Meds Flashcards
What is a muscle spasm?
An involuntary, painful, sudden muscle contraction that occurs with musculoskeletal trauma or inflammation
What is muscle spasticity?
Involves muscle contraction or tone and stiff, awkward movements
What is the prototype drug for muscle spasms?
baclofen (Lioresal)
What are the 4 therapeutic uses of baclofen?
CP, MS, muscle pain, spinal cord injuries,
List common 8 adverse drug reactions (ADRs) of baclofen
Confusion, Constipation, Dizziness, Drowsiness, Fatigue, Nausea/Vomiting, Urinary Retention, Weakness
What should be monitored (3 things) during the administration of dantrolene?
CNS effects, diarrhea, liver function tests (LFTs)
What are the 5 therapeutic uses of dantrolene? (Think disease/symptoms/conditions)
CP, CVA, MS Malignant hyperthermia, spasticity from spinal cord injuries
What is the definition of a seizure?
A brief episode of abnormal electrical activity in nerve cells of the brain
What defines epilepsy?
Recurrent seizures
What is status epilepticus?
A life-threatening emergency characterized by generalized tonic-clonic convulsions lasting several minutes
What are the 4 types of generalized seizures?
Absence, Akinetic, Myoclonic,Tonic-Clonic
What is the prototype traditional antiepileptic drug?
phenytoin (Dilantin)
What is the mechanism of action of phenytoin (Dilantin)?
Suppress sodium uptake in neurons, reducing neuronal activity in seizure-generating cells
List common 3 adverse effects of phenytoin (Dilantin)
CNS depression, Gingival hyperplasia, Skin rash (SJS)
What is the boxed warning for phenytoin (Dilantin)?
Do not give IV too quickly; risk of cardiac collapse