Neuro extra stuff Flashcards
Describe the layers of the cerebellum
VI layers then White matter. VI to thalamus V to subcortical I-IV to cortex Thalamus to IV BS to all Cortex to I-IV
Parietal dominant function?
Speech (Brocas) and language
Logic - calculation
Problem solving
Motor skills
Lesion in anterior frontal results in?
Loss of personality Apathy Asociality Loss of social rules/ inhibition Euphoria without feeling so amoral
Temporal lesion
Memory e.g. people/ agnosias/ recognition
Speech
Parietal non dominant function
Emotion of language Music/art Visiospatial Body awareness Whole pucture
How are the left and right sides of the brain connected?
Corpus callosum and anterior and posterior commissures
Where does the interpretation of written and spoken word occur?
Wernicke’s area temporal lobe
Function of the angular gyrus?
Written word interpretation from occipital to Wernicke’s via angular gyrus
How does information pass from Wernicke’s area to Brocs’s?
Via the arcuate fasciculus
What are the types of memories and where are they stored? What feature of neurones allows this to happen?
Declarative- cortex, hippocampus and other cortical regions
Procedural - Cerebellum, basal ganglia, pre-motor cortex
neuronal plasticity
Storage of memory?
Intermediate = seconds allowing sense of present
Short = seconds to minutes = working memory
Transfers to long spontaneously or based on emotion, rehersal association.
Consolidation occurs via long term potentiation
How does memory formation occur? how do we forget?
Sensory info to sensory cortex. Then forms a loops with amygdala/ hippo/ thalamus/ basal forebrain/ pre frontal cortex and back.
Long term potentiation with NDMA glutamate receptors]
Result of the destruction of the hippocampus?
Antereograde amnesia
What is amnesia? Causes
Vascular interrution
Trauma
Infections, Vit B def
Retrograde in alzheimers
What is dementia
An aquires loss of global brain function that is significant enough to effect dailey function and quality of life
Loss includes intellect reason and personalit without loss in consciousness (with delerium there is)
Symptoms of dementia
Loss of progressive: Memory intellect personality behaviour speech movement (bradykinesia)
Causes of dementia briefly
Vascular (20%) ALzheimers Lewi bodies Fronto-temporal dementia Drugs
Protein and the deal with Alx
B amyoid deposition
Neurofibillary tangles
Prognosis 5 years
AGe and female = RF
Protein and the deal with lewi bodies
alpha synuclein prognosis 8 years REM bleep behaviour disorder fighting in sleep Delusions paranoia Later it resembled alzheimers dementia
Protein and the deal with fronto-temporal dementia
T Tau Prog = 8 years Behaviour and personality loss Semantic dementia (loss of meaning from language/ words) Progressive non-fluent aphasia Disinhibitions lOss motivation Lack of empathy Repetitive Convulsive behaviours Craving of sweet, fatty, alcohol, ciggs Loss of table etiquette
Describe early dementia
Loss of memory for recent events
Global distruption of personality
Gradual change in behaviour
describe intermediate dementia
Loss of intellect
Mood changes
Cognitive failure to learn
Describe late dementia
Reduction in self care
REstless wandering
Incontinence
Differentials for dementia
Delerium
Depression
What is normal pressure hydrocephalus and when does it occur
Symptoms = Dementia, incontinence and gait disturbance
Ventriculomegally (caused byu build up of CSF?)
Rare
Which layers does meningitis affect?
Leptomeninges = Pia and arachnoid