Neuro Exam 1 Flashcards

1
Q
Most common inflammatory myopathy in dogs, results in generalized weakness, stiff gait, muscle atrophy and if severe can result in aspiration pneumonia from megaesophagus. 
A) Masticatory muscle myositis
B) Botulism
C) Myasthenia gravis
D) Tick paralysis 
E) Autoimmune polymyositis
A
E= correct- responds well to pred, may see hypergammaglobulinemia
A= aka eosinophilic myositis, masticatory mm effected= responds well to pred 
B= end plate condition
C= end plate condition
D= neuropathy
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2
Q
A lesion in the left brainstem would show signs in the:
A) Left side of the body
B) Right side of the body
C) Both sides
D) IDK
A

A

if in left cortex= signs on right limbs

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3
Q
A dog that can bear weight on the limb, has no patellar reflex, and has an intact flexor withdrawal when lateral digit is stimulated but absent when the medial digit is stimulated has a lesion where?
A) Sciatic nerve
B) Femoral Nerve
C) Caudal to L3
D) Any of the above
A

B

sensory branch of femoral n is responsible for patellar reflex and sensory to medial aspect of limb

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4
Q
An animal has begun to display signs of somnolence and has had difficulty maneuvering with the let side of its body. UMN signs are present only in the left fore and hind limbs. Cranial nerve reflexes are abnormal. Where is the lesion most likely located?
A) Left spinal cord C1-C5
B) Right cortical cerebrum
C) Left brainstem 
D) None of the above
A

c

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5
Q

Which of the following is false regarding limber tail?
A) tail is flaccid
B) the animal often has a history of prolonged cage rest after a hard work out the day before
C) the condition is permanent
D) all of the above are true

A

C= recover with rest and NSAIds

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6
Q
An animal displaying ataxia but hypertonic reflexes most likely has a lesion where?
A) Spinal cord
B) LMN
C) brainstem or cortex 
D) None of the above
A

C

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7
Q
A 9 y/o dog presents with left hind limb knuckling with CP deficits in this leg. The neuro exam shows absence of perineal reflex on left side and no response to pain in this area. The patellar reflex is normal while the cranial tibial reflex is absent. The myelogram displayed the golf tee sign caudal to L7. Which of the following diagnoses fits the clinical signs and diagnostic test the best?
A) FCE at L7
B) IVDD at L7
C) Osteosarcoma at L7/S1
D) Meningioma at L7/S1
A

D= intradural extramedullary tumors show this sign (meningiomas + MPNST)

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8
Q
A broad based stance, dysmetria (overreaching or underreaching), intention tremors present when the lesion is in the :
A) Cerebellum
B) Vestibular system
C) Spinal cord lesions 
D) lesions in motor cortex
A

A

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9
Q

Which of the following is true regarding acute idiopathic polyradiculoneuritis?
A) Ascending LMN signs occur that may progress to tetraplegia
B) CN and continence is abnormal
C) Steroids are helpful in treatment
D) Supportive care is most important, resolves spontaneously
E) Due to degeneration of dorsal nerve roots

A

A + D are true
B is false= they are spared
C is false= steroids don’t help
E= ventral nerve roots

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10
Q
An animal is displaying UMN signs on the limbs of the left side and the owner reports changes in behavior and presence of seizures. The menace response is absent on the left along with an absent nasal aversion response although there was a reflex twitch of the nostril.  Which of the following is the most likely cause?
A) Lesion in spinal cord at C1-C5
B) Lesion in the left brainstem
C) Right cerebral cortical lesion
D) Left cerebral cortical lesion 
E) Lesion in the right brainstem
A

C

if it was a brainstem lesion, the cranial nerve reflexes would be abnormal

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11
Q
A dog displaying neuro signs in the hind limbs has an absent cranial tibial reflex but what seems like an overreactive patellar reflex. The flexor withdrawal test shows flexion of the hip but not of the hock. There is absence of the perineal reflex. Which of the following is the most likely cause?
A) Lesion from T3-L3
B) Lesion from L4-S4
C) Lesion is caudal to L5
D) Lesion is in the brain
A

C

because the femoral nerve is intact, we know that the lesion must be caudal to L5 (the femoral nerve exits around L4,5)

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12
Q

An animal is able to walk normally on the hind limbs but is fecal and urinary incontinent. Which of the following is true?
A) The lesion is in T3-L3
B) The lesion is anywhere from T3-L7
C) The lesion is caudal to L7
D) The lesion is in the caudal spinal cord segment

A

C

D= tail dysfunction only

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13
Q

T/F: 50% of cats with myasthenia gravis have thymomas unlike dogs where incidence of a thymoma is much lower.

A

True

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14
Q

T/F: Tick paralysis can sometimes be classified as an end plate condition rather than a neuropathy.

A

True- can inhibit presynaptic Ach @ motor end plates//neuropathy= when toxin blocks conduction of impulses along distal portions of motor n.

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15
Q

How will the bladder be effected with a T3-L3 lesion?
A) UMN bladder
B) LMN bladder
C) Normal bladder

A

A UMN bladder= firm/easily palpable, difficult to express

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16
Q
An owner brings her dog in because she refuses to walk up the stairs any more. You observe that the pet takes short steps. Postural reactions are normal. You perform a flexor withdrawal reflex for each limb. The front limbs are normal while in the hind limbs, the patient flexes her joints and responds to pain but is unable to resist your pressure that you apply. Which of the following is the most likely cause of these cs?
A) botulism
B) Lesion at L3-S2
C) Cerebral cortical lesion
D) myopathy
A

D

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17
Q

Which of the following is false regarding EIC in labs?
A) Occur more commonly in labs that hunt in cold conditions
B) Occurs after intense work, play, or excitement
C) Thought to be linked to a mutation in dynamin-1 protein
D) Can be treated with phenobarbital
E) Clinical signs include ataxia and rocking horse gait

A

A= no related to type of work or temperature

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18
Q
A lesion in the left brainstem will show UMN signs:
A) In all 4 limbs
B) In limbs on left side
C) In limbs on right side
D) none of the above
A

B

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19
Q
Sensory ataxia includes, crossing-over of limbs, scuffing toes while walking, and CP deficits. Which of the following is affected when this is present?
A) Cerebellum
B) Vestibular system
C) Spinal cord lesions 
D)  motor cortex
A

CD

aka conscious proprioception

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20
Q
Which of the following is characterized by weakness and persistent ventroflexion of the neck in cats?
A) Myotonia congenita
B) Feline hyperesthesia syndrome
C) Hypokalemic myopathy
D) Tetanus
A

C is correct= RMP is increased, m. contraction is more difficult (no neuro signs)
-A= sustained depolarization of m fibers, very stiff, hypertrophy of jaw/tongue= may not eat
B=seizure like activity or degenerative myelopathy
D= stiff, saw horse stance

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21
Q

What four things does the flexor withdrawl response/reflex test?

A

1) Muscle strength
2) In tact LMN- if no reflex= not in tact
3) In tact UMN= hyperreflexive
4) Sensation

22
Q
Choose the condition that best fits the clinical signs: an 8 y/o dachshund is experiencing tetraparalysis, anorexia, reluctance to move, and cries out during head/neck manipulation; no other abnormalities on PE or blood work  
A) Hypokalemic myopathy
B) Cervical disk dz 
C) Mytonia congenita
D) Tetanus
A

B

23
Q

Which of the following is false regarding M.gravis?
A) Can be congenital or acquired (autoimmunity to AchR)
B) Antibody tests are more successful in diagnosing a higher number of cases compared to the tensilon test which may miss focal cases
C) UMN signs are seen on all 4 limbs
D) Pyridostigmine or neostigmine are used to treat
E) There are generalized and focal forms

A

C= LMN signs are seen

24
Q
A dog presents with sudden limping on his right forelimb. Hind limb reflexes are normal. Reflexes are normal in the left forelimb but absent in the right. The panniculus reflex is decreased. The right pupil appears smaller than the left. Which of the following is the most likely cause?
A) Right sided lesion from C1-C5
B) Right sided lesion from C6-T2
C) Brachial plexus avulsion
D) Peripheral nerve disease
A

C- spinal cord segments are normal because there are no UMN signs in the hind limbs= just the right forelimb is showing LMN= problem in the LMN on this side….he has Horner’s syndrome (we know T1 is effected)= brachial plexus evulsion

25
Q
A puppy is paralyzed on his front right leg. He received vaccines very recently. Which of the following is the most likely cause?
A) Envenomation
B) Anaphylaxis
C) Coonhound paralysis
D) Brachial plexus neuritis
A

D

26
Q

Which of the following is false regarding syringomyelia?
A) Is due to abnormal CSF movement
B) Animals are painful, vocal, and may scratch at neck
C) High incidence of this condition in KCS
D) Other than pain, the animal walks relatively normal

A

D- animal has cerebellovistibular signs and neuropathic pain (allodynia)

27
Q

Which of the following is false regarding dystrophic degenerative myopathies?
A) inherited abnormality of cytoskeleton protein, dystrophin
B) occurs in puppies and results in stunted growth, weakness, and gait abnormalities
C) characterized by marked muscle hypertrophy
D) older animals die from DCM
E) may cause esophageal dysfunction

A

C= marked muscle atrophy and fibrosis…causes contracture of tarsus

28
Q
If an animal is showing paraplegia on the hind limbs and has a normal patellar reflex, but an absent cranial tibial reflex, where is the lesion?
A) Caudal to T3
B) Caudal to L3
C) Caudal to L5/L6
D) Caudal to S1
A

C-femoral nerve comes out around L4/5, Sciatic is L6/7

29
Q

A young cat presents for sudden onset of weakness, pronounced cervical ventroflexion, and an inability to jump. Blood work is normal. Which of the following is the most likely cause?
A) Dermatomyositis
B) Feline hyperesthesia syndrome
C) Hypokalemic myopathy
D) Feline idiopathic inflammatory myopathy

A

D is correct
a= inflammatory dz of capillary walls,= facial dermatitis
b= not the right cs
c= bw would be abnormal

30
Q

T/F: Pyridostigmine may be effective in reducing clinical signs of tetanus.

A

False- in botulism it may help

31
Q
Which of the following conditions can be diagnosed by percussing the tongue (or other muscles) and seeing dimpling of the muscle?
A) Masticatory muscle myositis
B) Autoimmune polymyositis
C) Exertional myopathy 
D)Myotonia congenita
A

D

32
Q
Which of the following conditions would we see the highest increase in CK?
A) Masticatory muscle myositis
B) Autoimmune polymyositis
C) Exertional myopathy 
D) Exercise intolerance
A

C- myonecrosis can occur, many die of renal failure

33
Q

Which of the following is false regarding botulism?
A) Tetraparesis begins in the hind limbs and progresses to forelimbs- will see hypo or areflexia
B) CNs, esophagus, and PSNS may be involved
C) Death from respiratory depression can occur
D) Characterized by saw horse stance
E) Onset occurs about 6 days after toxin ingestion

A

D- this is tetanus

side note: supportive care is very important for botulism especially if they have LMN signs

34
Q
Which of the following are signs a lesion is in the brainstem?
A) compulsive circling
B) somnolence
C) unaware of surroundings
D) lethargy
A

BD

the other two are thalamocortex signs

35
Q

T/F: Prednisone works well to treat autoimmune M. gravis resulting in increased muscle strength.

A

False- can be used to treat but can exacerbate muscle weakness and aspiration pneumonia

36
Q
If all of the reflexes are normal in the front limb but the panniculus reflex is decreased, then there is likely a lesion caudal to:
A) C7
B) T1
B) L1
D) Any of the above
A

B

motor to panniculus is from C8-T1 and sensory spans caudal to the brachial plexus 1-2 spinal segments cranially

37
Q
A dachshund presents with paraplegia. Hind limb reflexes are present and the bladder feels firm and is difficult to express. The myelogram shows a bulged disc at T12-T13. Which of the follow is most likely occurring?
A) Degenerative myelopathy
B) Thoracolumbar IVDD
C) Cauda equina syndrome 
D)  Discospondylitis
A

B

38
Q

List 4 diseases that affect the peripheral nerves and result in LMN signs to all 4 limbs.

A

M. gravis, botulism, coonhound paralysis, tick paralysis

39
Q
A dog presents with drooping on the left side of the face, ataxia, and lethargy. Which of the following is the most likely cause?
A) Cerebral cortical lesion
B) Brainstem lesion
C) Spinal cord lesion
D) Ear infection
A

B - wouldn’t be lethargic with an ear infection

40
Q
A dog is displaying vertical nystagmus during the oculocephalic reflex exam. Which of the following is true?
A) This is normal
B) The dog has a vestibular lesion
C) The dog has a spinal lesion
D) The dog has a cortical lesion
E) The dog has a cerebellar lesion
A

B- horizontal nystagmus is normal, vertical= vestibular

41
Q

An animal in lateral recumbency has a positive crossed extensor reflex in the hind limbs. Where is the lesion?
A) in an UMN
B) in a lower LMN
C) Could be in either

A

A- this is an UMN sign

42
Q

Which of the following is false regarding protozoal polyradiculoneuritis?
A) Occurs most commonly in puppies
B) Is more commonly due to neospora than toxocara in dogs
C) Characterized by progressive posterior paralysis with extensory rigidity of pelvic limbs
D) Serology is the best method for definitive diagnosis
E) May cause scar formation in the muscles, myositis, and contracture of muscles

A

D= many are sero+ and do not show signs,histopathology is better for definitive diagnosis

can also result in dermatitis, CN V neuropathy, necrotizing cerebellitis and encephalitis

43
Q

Name the condition:
- spinal cord compression in caudal cervical area cause by either: congenital stenosis of vertebral canal, Hansen type II disc, hypertrophy of ligamentum flavum, or osteophytes at articular processes–> results in stiff gait in thoracic limbs, cervical hyperesthesia with neck gaurding

A

Cervical spondylomyelopathy/ canine wobblers

44
Q

Which of the following is false regarding atlanto-axial subluxation?
A) Can be congenital in toy breeds that are born without a dens
B) spinal cord compression occurs by dorsal displacement of axis
C) Animals often die from respiratory paralysis and surgery has a high failure rate
D) Can be diagnosed by performing a thorough PE on the neck

A

D

45
Q
Which of the following conditions occurs due to the blocking of Ach release from presynaptic membranes?
A) Tetanus
B) Botulism
C) M.gravis
D) All of the above
A

B is correct
A= blocks input of inhibitory interneurons on spinal motor neurons
C= reduced Ach receptors

46
Q
A dog presents as tetraplegic with no reflexes in any of the limbs. Which of the following is the most likely cause?
A) Lesion at C1-C5
B) C6-T2
C) Tick paralysis 
D) Any of the above
A

C
A= UMN signs in all 4
B= UMN in hindlimbs

47
Q

Which of the following is false regarding tetanus?
A) Inhibitory interneurons are active all the time on spinal motor neurons
B) occurs about 10 days post wound infection
C) Animals may die from hyperthermia
D) Will often see pricking of ears, sardonic grin, and strismus
E) Midazolam alone is effective in providing adequate muscle relaxation

A

E= ace, valium and pentobarbital are used= need stronger drugs

48
Q

t/f: If all postural reactions are normal, neurological disease is ruled out.

A

true

49
Q

Which of the following is false regarding tick paralysis?
A) Occurs about 5 days after tick attachment
B) CS are slow onset and include mild paresis to tetraplegia
C) CNs,continence, and sensation is spared
D) All of the above are true

A

B= rapid development of signs

50
Q
Which of the following drugs are used to treat UMN bladders by dilating the bladder sphincter?
A) PPA
B) Phenoxybenzamine
C) Prazosin
D) Urecholine
E) Tamsulosin
A

BCE
A= tights sphincter
D= contracts detrusor m.- can be used in UMN and LMN bladders but doesn’t have same MOA

51
Q
A cat presents with dragging of the hind limbs. Reflexes are present in the hind limb. What is the most likely cause?
A) Tumor at L4-S3
B) Cervical disc dz
C) Lesion somewhere from T3-L3
D) none of the above
A

C (because hind limb reflexes are present, the lesion is cranial to L4)

52
Q
Which of the following metabolic conditions is not linked to causing a myopathy?
A) Hypothyroidism
B) Hyperthyroidism
C) Cushing's
D) Addison's
A

D