Neuro/Endo Systems Flashcards
Communication System that detects, processes, and responses to stimuli
Nervous System
Evolutionary concentration of interneurons at anterior end of organism
Cephalization
Type of excitable cell that detects and processes stimuli
Neuron
Structural and metabolic support for neurons
Neuroglia
What are the three types of neurons and their functions
- Sensory: detect stimuli (receptors)
- Interneurons: integrate signals (integrators)
- Motor: signal effectors to perform actions
Two Types of Nervous Systems and function
- Central: Processes and responses to signals
2. Detects and relays signals, responses
Main Nerves in Body and number
Cranial (12 pairs) Cervical (8 pairs) Thoracic (12 pairs) Lumbar (5 pairs) Sacral (5 pairs) Coccygeal (1 pair)
Ulnar (1/arm)
Sciatic (1/leg)
Axons relaying signals into CNS
Afferent
Axons relaying commands from CNS
Efferent
Neuron extensions that receive signals
Dendrites
Neuron extension that sends signal
Axon
Zones of a neuron
Input zone (cell body and dendrites) Trigger zone (special membrane section) Conducting zone (axon) Output zone (axon ending/synapse)
Term for Electric Gradient across neuron not receiving a signal
Resting Membrane Potential ~= -70 mV
Stimulation of excitable cell
Action Potential
An Action Potential is…
an abrupt reversal of the electric gradient across a neuron
Neurons maintain resting potential by…
- actively pumping Sodium out of cell and Potassium into cell
- more potassium, less sodium in cell
-sodium not able to leak back into cell
Action Potential triggers voltage reversal by…
Openings voltage-activated sodium and potassium gates
Steps of an action potential:
- Pressure, other stimulus on sensory neuron deforms membrane, allows ions through. Creates graded potential
- If potential is above threshold level, gated ion channels open, bringing in sodium ions.
- Increasing positive charge of cell leads to more gates opening (positive feedback mechanisms)
- Action Potential self-propagates along conducting zone (axon)
What is the Threshold Level?
Voltage needed to activate gated ion channels in trigger zone
Why is an AP an all-or-nothing event?
Because once the threshold level has been reached, stimulus strength has no bearing on proceeding AP, same number of gates will open due to positive feedback.
Why does an AP flow only one way?
Because after a timeout period, ion gates close and are deactivated for awhile, causing ions to only be able to flow to a new part of the conducting zone.
Point of interaction between two neurons (signal transfer location)
Chemical Synapse
Cell sending a signal across a synapse
Presynaptic cell
Cell receiving a signal across a synapse
Postsynaptic cell
Gap between pre- and postsynaptic cells
Synaptic Cleft
Signalling molecule that relays message between neurosystem cells
Neurotransmitter
Sum of all signals entering an interneurons
Synaptic Integration
Neurotransmitter that induces muscle contractions in smooth muscle, slows cardiac contraction, has roles in mood and memory
Acetylcholine (ACh)
Neurotransmitter that speeds heart rate, dilutes pupils and airway, slows gut contractions, increases anxiety
Epinephrine, norepinephrine
Aka Adrenaline
Neurotransmitter that dampens other neurotransmitters, has roles in memory, learning, fine motor control
Dopamine
Neurotransmitter that elevates mood, has role in memory
Serotonin
Neurotransmitter that inhibits release of other neurotransmitters
GABA