Neuro emergencies Flashcards

1
Q

Neuro exam in emergency setting?

A
  • key is medical hx
  • time of onset
  • sx progression
  • assoc sxs
  • exacerbating factors
  • once at ER assess neuro status
  • use glasgow coma scale - if pt deteriorated during transport needs immed non-contrast CT scan and possible neurosurgery consult
  • if pt stable and not comatose with stable VS and no focal neuro findings: you can proceed more slowly
  • goal is to prevent brainstem or uncal herniation and brain edema with elevated ICP that causes further brain injury
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2
Q

What is impt hx information for head trauma injury?

A
  • when, where and how injury happened
  • mechanism of injury
  • if there was LOC at the scene
  • if ETOH or drugs were involved
  • length of time from injury
  • underlying medical problems (diabetes, previous stroke, CVD)
  • allergies and meds
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3
Q

What should be eval on a head trauma physical exam?

A
  • vital signs
  • glasgow coma scale
  • examine head for signs of outward trauma (penetrating trauma, lacerations, swelling, bruises, abrasions)
  • pt should be in cervical spine collar
  • neuro exam:
    pupils
    level of alertness
    look for focal deficits: facial droop, leg or arm not fxning
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4
Q

What is a TBI? GCS ratings?

A
  • head injury due to contract or accel/deceleration forces
  • mild: GCS 13-15 measured 30 min after injury
  • moderate: 9-12
  • severe: 8 and lower
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5
Q

WHat is a concussion?

A
  • trauma indcued alteration in mental status may or may not involve LOC
  • caused by direct blow to head, face, neck or body
  • fxnl not structural neuropathologcial changes
  • normal imaging studies
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6
Q

What are associated sxs with TBI?

A
  • LOC or not, confusion, amnesia, length of these sxs
  • assoc sxs:
    HA, dizziness, vertigo or imbalance, lack of awareness of surroundings (disorientation), N/V
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7
Q

Signs assoc with TBI?

A
vacant stare
inability to focus
gross incoordination
memory deficits
delayed verbal expression
slurred or incoherent speech
emotionality out of proportion to events
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8
Q

Presentation of complicated TBI?

A
  • post traumatic seizures
  • focal neuro signs
  • neuro deterioration
  • worsening HA, confusion, focal neuro signs or lethargy - think Intracranial hemorrhage
  • other injuries to head and neck (esp in older pts)
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9
Q

PP of primary injury phase of TBI? Cortical contusion and indirect trauma?

A
  • cortical contusion: direct trauma
    coup and contrecoup
  • diffuse axonal injury: disruption of axonal neurofilament organization - impairs axonal transport leads to axonal swelling
  • indirect trauma: SBS or severe whiplash that shakes or rotates the brain
  • greatly stretches and damages nerve cells causing sig damage and even death in adults and may cause perm brain damage
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10
Q

Indications for CT scan in ER?

A
  • GCS of less than 15
  • susp open or depressed skull fracture
  • any sign of basilar skull fracture: CSF leak, battle’s sign, raccoon eyes, hemotypanum
  • 2 or more episodes of vomiting
  • 65 or older
  • amnesia before impact of 3 or more minutes
  • dangerous MOI (eject from vehicle)
  • bleeding diathesis or oral anticaog use
  • seizure
  • focal neuro sign
  • intoxication
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11
Q

What to look for on CT scan in ED?

A
  • cranial contours
  • cisterns (any opening in subarachnoid space created by sep of arachnoid and pia mater) - open vs closed
  • midline shift?
  • lesions? type, location
  • acute blood - white
  • old blood - dark
  • ventricles and cisterns are black
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12
Q

CT scan abnorm that require a consult?

Likelihood of neuro normal pt with normal CT scan having a problem?

A
  • subdural hematoma
  • intracranial bleeding
  • cerebal edema
  • sig skull trauma
  • low risk for neuro deterioration with normal CT scan
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13
Q

What pts should be hospitalized or transfered?

A
  • GCS of less than 15 or deteriorating
  • abnorm CT
  • seizures
    abnorm bleeding parameters
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14
Q

What pts can leave?

A
  • if GCS = 15
  • normal CT scan
  • responsible caretaker to awaken pt from sleep q 2 hrs to check for warning signs:
  • inability to waken pt
  • severe or worsening HAs
  • somnolence or confusion
  • diff with vision
  • urinary or bowel incont.
  • weakness or numbness involving any part of the body
  • unsteadiness or seizures
  • vomiting, fever or stiff neck
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15
Q

Scalp lacerations and tx of bleeding?

A
  • common with head injuries
  • source of sig bleeding
  • hemostasis: is best achieved with closure of laceration
  • may be delayed in unstable pt
  • direct compression or compression bandage may be applied
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16
Q

Scalp laceration repair?

A
  • anesthetize wound edges with:
    lidocaine1-2% with epi
  • thoroughly debride and irrigate
  • if deep may use horizontal mattress sutures
  • otherwise interrupted sutures or staples
  • no need to shave head most of time
  • when repairing scalp wound palpate skull for depression or step off fracture
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17
Q

Clinical sig skull fractures?

A
  • pass through an air filled space (sinus)
  • assoc with overlapping scalp laceration
  • depressed below level of skull’s inner table
  • overlie a major dural venous sinus or middle meningeal artery
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18
Q

When are linear skull fractures clinically impt?

What do they look like on xray? heal time?

A
  • impt if they cross middle meningeal artery or major venous sinus
  • most other linear fractures aren’t sig
  • fractures are brighter on xray than sutures and usually are wider (3 mm compared to 2 mm for sutures)
  • kids - fx heals 3-6 months
  • adults: up to 3 years
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19
Q

Depressed fractures presentation

A
  • may be diff to view on X-ray
  • can often be felt on palpation beneath scalp laceration
  • impt b/c they predispose to sig underlying brain injury and to complications of head trauma (infection and seizures)
  • with a depressed skull fracture traumatic impact drives bone piece below plane of skull
  • 25% of pts with depressed fracture report LOC
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20
Q

basilar fractures presentation?

A
  • linear fractures at base of skull
  • usually occurs through temporal bone
  • often cause dural tear producing a communication b/t subarachnoid space and paranasal sinuses and middle ear: lead to infection of cranial cavity, can produce CSF leak through nose
  • radiographs don’t detect basilar fracture well
  • get CT if suspected
21
Q

Open skull fracture?

A
  • open if there is an overlaping scalp laceration and dura is disrupted
  • a fracture that disrupts paranasal sinuses or middle ear structures is also considered open
  • reqr careful debridement and irrigation
  • blind probing of wound should be avoided as contaminants can be introduced into wound and can further depress comminuted fracture pieces
22
Q

Characteristics and Tx of migraines?

A
  • unilateral, aura ( feel unweel, flashing lights)
  • 1st line: tryptans
  • 2nd line: ketorolac (IV) + antiemetic (metoclopramide or prochlorperazine)
  • IV fluids
23
Q

Cluster HA characteristics and tx?

A
  • middle aged man, excruciating pain behind their eye (feels like a hot poker)
  • tx:
    1st line: 100% O2
    2nd: Sumatriptan
24
Q

Thunderclap HA?

A
  • subarachnoid hematoma (SAH)

- assoc with nausea and maybe vomiting

25
Q

What are some potentially life threatening causes of HA?

A
  • SAH
  • bacterial meningitis
  • cerebral ischemia
  • subdural hematoma
  • brain tumor
26
Q

Etiologies of seizures?

A
- alcohol assoc:
withdrawal
exacerbation of idiopathic seizures
acute intoxication
- metabolic 
- infectious
- trauma
- CVA
- sleep deprivation 
- noncompliance with anticonvulsant
- 1st time idiopathic seizure (No good in adults!)
27
Q

Status epilepticus etiologies?

A
  • hypo- natremia, glycemia, calcemia
  • CNS abscess
  • meningitis or encephalitis
  • neoplasm
  • AV malformations
  • acute hydrocephalus
  • intracerebral hematomas
  • CVA
  • cyclic antidepressants (amitriptyline - Elavil)
  • migraines
  • failure to take anticonvulsants
28
Q

Decerebrate posturing meaning?

A
  • poor prognosis
  • uncal herniation
  • severe brain damage
29
Q

Seizure management?

A
  • a pt presenting with generalized seizure or status epileptics:
    AIRWAY management: gag reflex suppressed, suction available, roll on side if vomiting
  • consider thiamine
  • get as much hx as possible - epileptic? trauma, infectious signs, sudden deterioration, drug or alcohol abuse
  • IV est
  • BENZODIAZEPINES 1st choice (lorazepam)
  • dextrose bolus, narcan
  • 2nd line drugs: phenytoin and phenobarbital. phenytoin long onset, acting, benzodiazepine support should be continued
  • phenytoin IV can cause hypotension and bradycardia
  • phenobarbital causes sedation, depression of resp drive and BP so pt must be monitored closely
30
Q

What is the post ictal state?

A
  • diff post-ictal state and syncope of another cause
  • state:
    usually sleepy and may be confused, often incontinent, tongue bitten
  • supportive care: IV, O2, primary assessment
  • underlying cause?
31
Q

Etiologies of vertigo

A
- central:
migrainous
brainstem ischemia
cerebellar infarction and hemorrhage
MS
- somatic:
panic attack
weak dizzy, nearly fainting pt
- peripheral:
benign paroxysmal positional vertigo
vestibular neuritis
herpes zoster oticus
meniere's disease
labyrinthitis
perilymphatic fistula
acoustic neuroma
aminoglycoside toxicity (commonly seen in CF pts)
- otitis media
32
Q

Dx cause of vertigo?

A
  • N/V more severe with peripheral casues
  • gait disturbances more pronounced with central etiologies
  • generally central etiologies last for hrs - days, while peripheral are recurrent and last for few minutes to 2-3 hrs
  • impt to get a good hx, PE (look for nystagmus and focal neuro signs)
  • look at RFs for more serious central disease
33
Q

What is a TIA? Sxs?

A
  • brief stroke like attack, most sxs last 5-20 min, rarely longer than an hour, w/o evidence of acute infarction
  • if neuro defects last 4 hrs or longer pt often has infarcts on MRI
- sxs:
hemiparesis, hemiparesthesia
dysarthria, dysphasia, and diplopia
circumoral numbness
imbalance
monocular blindness
34
Q

TIA and CVA relationship?

A
  • among pts who present to ER with TIA 5% will have CVA in 2 days and 25% will have recurrent event in 3 months
  • urgently ID the cause of pts first stroke or TIA is crucial for determining proper therapy to prevent a second, more disabling event
  • since neuro signs/sxs subte and timing inexact - should usually get CT or MRI to r/o infarct
35
Q

Work up of TIA?

A
  • depends on suspected area effected:
    low flow - internal carotid (Duplex US or transcranial doppler), MCA: MRA or CT angiography, verterbrobasilar: CT angiography

embolic: echo - embolism
EKG - a fib

lacunar: r/o others, dx of exclusion

36
Q

Differential for sudden loss of focal brain fxn?

A
  • CVA
  • seizures
  • atypical migraines
  • syncope
  • transient global amnesia
  • hypoglycemia
  • MS
  • brain tumors
  • subdural hematoma
  • infection
37
Q

3 subcategories of ischemic stroke?

A
  • thrombosis: large artery extracranial and intracranial occlusive disease or small penetrating artery disease
  • embolism from: heart, intra-arterial, aorta, paradoxical
  • systemic hypotension (hypoperfusion)
38
Q

Distingiushing CVA - hx ?s and presentation?

nature of sxs? (+ and -)

A
  • focal or nonfocal nature of episode
  • nature of sxs and their progression
  • duration and timing of sxs
  • assoc sxs during and after episode is more like a TIA
  • nature of sxs:
    + sxs: indicate active d/c from CNS neurons (visual, auditory, somato-sensory, motor)
  • sxs: indicate absence or loss of fxn (loss of vision, feeling or ability to move part of body)
39
Q

CVA management? Goals of initial assessment?

A
  • goals of initial assessment:
    ensuring medical stability (ABCs)
  • quickly reversing any conditions that are contributing to pts problem
  • moving towards uncovering the pp basic of pts neuro sxs
  • screening for potential CIs to thrombolysis in acute ischemic stroke pts
40
Q

Hx and PE for CVA?

A
  • Hx:
    find out if diabetic, hx of seizures
    hx of ETOH or drug abuse
    meds and any recent trauma

PE:

  • thorough CV exam: murmurs, pulses to check if irregular, listen for bruits
  • skin: sign of endocarditis, cholesterol emboli, ecchymosis, tongue laceration
  • fundoscopic exam
  • neck immobilized if evidence of serious trauma or question of fall
  • examine extremities for DVT, signs of systemic arterial emboli
41
Q

Immed studies to get in suspected CVA pt?

A
  • noncontrast CT or MRI of brain
  • EKG
  • CBC w/ platelets
  • CMP
  • serum glucose
  • PTT, PT, INR
  • O2 sats
  • preg test (woman child bearing age)
  • blood cultures x2 if fever
42
Q

Tx of CVA? BP importance?

A
  • pt should be flat or elevate head of bed no more than 15 degrees
  • BP:
    ischemic: often elevated, need elevation for perfusion pressure, don’t tx unless SBP greater than 220 or DBP greater than 120

hemorrhagic: balance b/t increased BP worsening bleeding and decreased BP decreasing perfusion (titrate BP to SBP 140-160)

hemorrhagic stroke on warfarin: need to reverse effects of warfarin - IV vit K, prothrombin-complex concentrates, FFP

  • thrombolytic therapy: within 3-4.5 hr window
  • R/O hemorrhag
  • meet eligibility criteria (no CIs)
  • antithrombotic therapy: initiate antiplatelet agent w/in 48 hrs of stroke onset
43
Q

What is a Myasthenic crisis? Myasthenia Gravis?

A

Myasthenia gravis: disorder of neuromuscular transmission affecting ocular, bulbar, limb and resp muscles

  • myasthenic crisis occurs when there is severe enough weakness to necessiate intubation: severe bulbar weakness produces dysphagia and aspiration that often complicates respiratory failure
  • often pt experiences generalized weakness as warning
44
Q

Management of myasthenic crisis?

A
  • if pt presents with weakness and not acute resp failure the FVC can be monitored q 1-2 hrs
  • elective intubation should be considered if serial measurements of FVC consistently decline approaching 15 ml/kg body weight
  • at times b/c weakness of oropharyngeal muscles, secretions can’t be handled and pt is at risk for aspiration so elective intubation in done in this setting
  • if pt in obvious respiratory failure emergent intubation is done, but elective intubation is preferable
  • plasmapheresis or IV immune globuline are done for tx
45
Q

MS acute exacerbations?

Tx?

A
  • result in fxnally disabling sxs with objective neurologic impairment (Loss of vision, motor and or cerebellar sxs)
  • tx with high dose IV glucocorticoids: such as methylprednisolone 1000 mg IV a day for 5 days
  • sometimes MS causes seizures - tx the seizure
46
Q

Tx of neuropathic pain syndromes?

A

-generally pts with chronic pain - may be on prophylactic meds to control pain, but are having breakthrough pain
- first elicit if anything new or different about pain to r/o new injury or illness
- if its chronic pain exacerbation discuss with pt level of pain and options for tx:
1 time IM dose of dilaudid or morphine
1 time dose PO opioid
start or increase proph med (neurontin)
importance of regular f/u with PCP and or pain specialist
- DONT give rx for narcotics
- reassure pt pain will decrease and can be controlled but it takes time
- assess for assoc depression and/or anxiety that may be making pain worse and make approp referral

47
Q

Presentation of guillian-barre syndrome?

A
  • symmetric ascending muscle weakness
  • weakness usually starts in proximal legs: begins in arm and facial muscles in 10% of pts
  • progressive to severe resp muscle weakness: 30% of pts will need ventilatory support, it can happen quickly
  • 80% will have paresthesias in hands and feet: sensory abnorm on exam most the time mild
  • often severe back pain
  • dysautonia: 70% - tachycardia, urinary retention, HTN-hypotension, bradycardia, ileus, loss of ability to sweat
48
Q

Dx of GBS?

A
  • LP: marked elevation of CSF protein with normal WBC count
  • neurophys studies: characteristic findings on EMG and nerve conduction
  • serum: glycolipid abs to gangliosides
  • features that make GBS doubtful:
    having a demarcation in sensation (sensation stops abruptly)
    marked persisent asymmettry of weakness
    severe and persistent bowel and bladder dysfxn
    more than 50 WBCs in CSF
49
Q

Tx of GBS?

A
  • close monitoring of resp failure - may reqr intubation and mechanical ventilation
  • close monitoring of heart rhythm, pulse and BP
  • fluids for hypotension
  • admission to ICU for further stabilization and tx