Neuro, Ears, and Eyes Flashcards
what is the patho of MS?
Chronic, progressive, degenerative, demyelinating neurologic disorder
what are the classifications of MS?
1) relapsing-remitting (most common); 2) primary progressive; 3) secondary progressive; 4) progressive-relapsing
MS is more common in…..
women
what are some DX tests for MS?
MRI, evoked potential response; CSF
what are some tx for MS?
disease modifying therapies (DMT’s)
immunomodulators, monoclonal antibodies, Corticosteroids, immunosuppressive agents, muscle relaxants, tricyclic antidepressants, anticholinergics.
what is the patho of PD?
-Progressive, degenerative neurologic disease, affecting voluntary motor functions.
-Failure of dopamine to inhibit acetylcholine
what are some TX for PD?
1) enhance release or supply of dopamine or
2) antagonize the effects of overactive cholinergic neurons:
- levodopa/carbidopa, dopamine agonists, anticholinergics, monoamine oxidase inhibitors, antidepressants, propranolol & botulism toxin.
what is a surgical option for PD?
deep brain stimulation (electrodes implanted into the brain and connected to a pulse generator)
what is the patho of huntington’s disease?
A single gene disorder – genetic autosomal. Progressive, degenerative, inherited neurologic disease → dementia and chorea. ↓ gamma-aminobutyric acid and acetylcholine levels. Excess of dopamine.
Tx for huntington’s disease:
There is no known cure or treatment for HD. Collaborative palliative care:
RX: tetrabenzine to treat the chorea; to decrease dopamine at the synapses; Others: haloperidol and risperidone; benzos, SSRI’s.
what is the patho for ALS?
rapidly progressive and fatal degenerative neurologic disease characterized by weakness and wasting of muscles under voluntary control.
PD is more common in…..
men
what is the patho of myasthenia gravis?
Chronic autoimmune neuromuscular disorder → fatigue & severe weakness of skeletal muscles with periods of remission. Antibodies destroy or block neuromuscular junction receptor sites ↓ acetylcholine receptors. Strength usually restored after period of rest.
what are some Dx tests for myasthenia Gravis?
Anticholinesterase test, nerve stimulation studies, anti-acetylcholine receptor antibodies and Tensilon tests.
what are some TX for myasthenia Gravis?
Thymectomy (40% remission with this surgery) for pt’s < 60; plasmapheresis; IV IgG. RX: anticholinesterase drugs (Mestinon), corticosteroids, immunosuppressants.
what is the patho for GBS?
Acute inflammatory demyelinating disorder of the peripheral nervous system → acute onset of ascending motor paralysis.
what are some DX tests for GBS?
↑ CSF protein, Electromyographic (EMG) studies that reflect ↓ nerve conduction.
what is some TX for GBS?
Plasmapheresis. IV immunoglobulin. Prolonged rehab. Recovery is slow.
what are some TX for trigeminal neuralgia?
phenytoin, rhizotomy: caution with applying any chemicals to face.
what are some TX for Bell’s Palsy
antivirals and steroids
do patients with bell’s palsy recover?
80% of patient’s recover within 2 weeks to a few months
pink eye or acute conjunctivitis is caused by?
staphylococcus, haemophilus, chlamydia or gonococcus.
what are some tx for acute conjunctivitis?
proper handwashing is imperative; RX: antibiotics (eye-drops), antivirals, anti-inflammatories and antihistamines
what is blepharitis?
Inflammation of the glands and lash follicles on the margins of the eyelid.
what is TX for blepharitis?
gentle cleansing with baby shampoo.
what is hordeolum (stye)?
Infection of one or more of the sebaceous glands of the eyelid
-staphylococcus aureus
what are tx for hordeolum (stye)?
warm moist compresses QID; antibiotics (possibly) and/or incision and drainage (I&D)