Neuro CIS Flashcards
A high fever with tachycardia can cause a ______ in a child secondary to increased cardiac output
Flow murmur
In young children, urine for culture should always be obtained via _____
Catheterization
[so RBC in urine is likely from trauma]
What does it mean to have an elevated WBC with left shift?
Indicates the presence of infection
Left shift occurs when immature neutrophils (bands) are pushed out of the marrow to fight something
The I/T (immature/total neutrophils) ratio can be helpful in determining presence of infection; if greater than 0.2, it is likely that infection is present
Etiologic bacteria that cause meningitis from birth-2 months old
Group B strep (Strep.agalactiae)
E.coli
L.monocytogenes (tx with gentamycin)
Etiologic bacteria that cause meningitis in age 2 months-12 years
S.pneumoniae (gram+ diplococci)
N.meningitidis (gram- diplococci)
H.influenzae (gram- coccobacilli) — less cases since vaccination
Etiologic bacteria that cause meningitis in adolescents and young adults
N.meningiditis
Etiologic bacteria that cause meningitis in age>60
S.pneumoniae
L.monocytogenes (tx with ampicillin)
The ____ and ____ vaccines have decreased the incidence of meningitis in children in all age groups except those less than 2 months of age
HiB; S.pneumo
CSF findings with bacterial meningitis
[opening pressure, WBC, PMN, glucose, protein, gram stain, cytology]
Opening pressure >300 mmHg (nml <170)
WBC >1000/mm3 (nml <5 monos)
PMN >80% increased
Glucose decreased
Protein increased
Gram stain POSITIVE (+0)
Cytology negative
CSF findings with viral meningitis
[opening pressure, WBC, PMN, glucose, protein, gram stain, cytology]
Opening pressure <300 mmHg (nml <170)
WBC <1000/mm3 (nml <5 monos)
PMN 1-50% increased
Glucose normal
Protein normal or slight increase
Gram stain negative
Cytology negative
Neoplastic CSF findings
[opening pressure, WBC, PMN, glucose, protein, gram stain, cytology]
Opening pressure 200 mmHg (nml <170)
WBC <500/mm3 (nml <5 monos)
Glucose decreased
Protein increased
Gram stain negative
Cytology POSITIVE
CSF findings with fungal etiology
[opening pressure, WBC, PMN, glucose, protein, gram stain, cytology]
Opening pressure 300 mmHg (nml <170)
WBC <500/mm3 (nml <5 monos)
PMN 1-50% increased
Glucose decreased
Protein increased
Gram stain negative
Cytology POSITIVE
What can cause CSF protein to be artificially elevated?
Presence of large number of RBCs, as seen in intracranial hemorrhage and traumatic taps
While there are no absolute contraindications to an LP, when should careful consideration be taken?
When there is strong suspicion of increased intracranial pressure, coagulation abnormalities, or suspicion of a spinal epidural abscess
[consider a CT prior to LP in patients with significantly altered mentation, focal neurologic signs, papilledema, hx of a seizure within previous week, or impaired cellular immunity]
Typical signs of meningitis
HA Fever N/v Nuchal rigidity Photophobia
How do you test kernig sign
Flex pts leg at both hip and knee and then straighten knee
Positive = extension of leg at knee when hip is flexed to 90 elicits PAIN
How do you test for brudzinskis sign
As you flex neck, watch hips and knees in reaction to your maneuver
Positive = flexion of neck elicits flexion at hips
When should fontanelles be checked?
In patients <2 y/o (anterior fontanelle is last to close around age 2)
[In a 3 yr old child, fontanelles will be closed and sutures are fused; the “typical” signs of ICP that coincide with meningitis will be present]
in suspected meningitis, Abx should be started as soon as labs have been drawn, with the option to tailor the medications later. What abx should empirically be given?
Vancomycin + Ceftriaxone
Add ampicillin if age 50+ and concerned for Listeria
Add acyclovir if suspicious of HSV encephalitis
Can add dexamethasone
Why do some docs choose to use Dexamethasone prior to abx for meningitis?
There is evidence that shows that administration of steroids PRIOR to abx can decrease hearing loss and neurological sequelae — depends on preference of physician if this is prescribed