Neuro Ch. 15 up to KCCs, CSV Flashcards
What regions of the CNShave no direct connetion to lower motor neurons?
basal ganglia and cerebellum
What is truncal ataxia?
unsteady gait
What is appendicular ataxia?
ataxia of the limbs
What is ataxia?
irregular, uncoordinated movement
What side is ataxia in relation to a cerebellar lesion?
ipsilateral
What are the deficits associated with midline lesions of the cerebellar vermis?
mainly truncal ataxia and eye movement abnormalities, often accompanied by intesnse vertigo, and N/V
What are deficits associated with midline lesions fo flocculonodular lobes?
mainly truncal ataxia and eye movement abnormalities, often accompanied by intesnse vertigo, and N/V
What are deficits associated with lesions lateral to the cerebllar vermis?
appendicular ataxia
What are the functions of the cerebellum?
intergrates massive sensory and other inputs to coordinate movement and motor planning
articulation of speech
respiratory movements
motor learning
certain higher order cognitive processes possible
What is the largest structure in the posterior fossa?
cerebellum
To what does the cerebellum attach?
dorsal aspect of pons and rostral medulla, by three white matter peduncles
What forms the roof of the fourth ventricle?
cerebellum
What regions/structures does the cerebellum consist of?
vermis and two large cerebellar hemispheres
What is the deepest fissure of the cerebellum?
primary fissure
Where is the primary fissure?
dorsal surface of cerebellum; separating the anterior and posterior lobes
Where is the posterolateral fissure?
ventral inferior surface of cerebellum; separating posterior lobe from the floculonodular lobe
Where is the vermis?
midline (between the two cerebellar hemishperes?)
The flocculonodular lobe has important connections to?
the vestubular nuclei
What is the nodulus?
The most inferior portion of the cerebellar vermis; the midline structure to which the two flocculi are connected
What connects the flocculi to the nodulus?
thin pedicles
What is the most inferior portion of the cerebellar vermis
nodulus
What can cause the tonsils to herniate?
mass lesions of the cerebrum or cerebellum, brain swelling with severely increased intracranial pressure
Where can the cerebellar tonsils herniate?
through the forament magnum
What is the result of tonsillar herniation through the foramen magnum?
compression of the medulla, which can result in death due to impingement on medullary respiratory centers
Where are the cerebellar tonsils?
inferior surface
What are the folia?
small ridges that run from medial to lateral on the surface of the cerebellum; (like gyri of cerebral cortex)
What forms the walls of the fourth ventricle?
cerebellar peduncles
What does the superior cerebellar peduncle mainly carry?
output fibers
What does the middle cerebellar peduncle carry?
mainly inputs
What does the inferior cerebllar peduncle carry?
mainly inputs
What cerebellar peduncles carry mainly outputs from the cerebellum?
superior peduncle
What cerebellar peduncles mainly carry inputs to the cerebellum?
middle and inferior peduncles
Alternative name of superior peduncle
brachium conjunctivum
Alternative name of the middle cereballar peduncle
brachium pontis
Alternative name of the inferior cerebellar peduncle
restiform body
How is the cerebellum divided?
into 3 functional regions based on input and output connections
What are the three functional regiosn of the cerebellum?
(medial) vermis and flocculonodlar lobes, intermediate hemispheres, lateral hemispheres (lateral)
What is the largest part of the cerebellum?
lateral hemispheres
What region of the cerebellum can have a large portion removed unilaterally without severe deficits?
lateral hemispheres
What is the function of the lateral hemispheres?
motor planning for extremities
What is the function of the intermediate hemispheres?
distal limb coordination (control of distal appendicular muscles in arms and legs)
What is the function of the vermis?
proximal limb and trunk coordination
What is the function of the flocculonodular lobe?
balance and vestibulo-ocular reflexes
What motor pathways are influenced by the cerebellar lateral hemispheres?
lateral corticospinal tract
What motor pathways are influenced by the cerebellar intermediate hemispheres?
lateral corticospinal trcat and rubrospinal tract
What motor pathways are influenced by the vermis?
anterior corticospinal tract, reticulospinal tract, vestibulospinal tract, and tectospinal tract
What motor pathways are influenced by the flocculonodular lobe?
medial longitudinal fasciculus (MLF)
What cerebellar regions influence the lateral corticospinal tract?
lateral and intermediate hemispheres
What cerebellar regions influence the rubrospinal tract?
intermediate hemispheres
What cerebellar regions influence the anterior corticospinal tract?
vermis
What cerebellar regions influence the reticulospinal tract?
vermis
What cerebellar regions influence the vestibulospinal tract?
vermis
What cerebellar regions influence the tectospinal tract?
vermis
What cerebllar regions influence the MLF?
flocculonodular lobe
Where does the superior cerebellar peduncle decussate?
caudal midbrain - at level of inferior colliculi
What nuclei are all cerebellar outputs relayed by?
Deep cerebellar and vestibular nuclei
What are the deep cerebellar nuclei from lateral to medial?
Dentate, Emboliform, Globose, Fastigial
What are the vestibular nuclei?
superior, medial and lateral
From what region does the dentate nuclei receive inputs?
lateral cerebellar hemispheres
From what region do the interposed nuclei receive inputs?
intermediate hemispheres
From what region does the fastigial nucleus receive inputs?
mostly vermis, small inputs from flocculonodular lobe
From what region do the vestibular nuclei receive inputs?
flocculonodular lobe
What is the largest deep cerebellar nuclei?
dentate nucleus
What nuclei is active just before voluntary movements?
dentate nucleus
What nuclei are active during and in relation to movements?
interposed nuclei
When is the dentate nucleus active?
just before voluntary movements
When are the interposed nuclei active?
during and in relation to movements
What are the interposed nuclei?
Emboliform and Globose
What are the layers of the cerebellar cortex? (superficial to deep)
molecular layer, purkinje cell layer, granule cell layer
What is contained within the molecular layer?
unmyelenated granule cell axons, purkinje cell dendrites, interneuons (basket cells, stellate cells), golgi cell dendrites
What cell type is extremely numerous?
granule cells - rival total of remainder of nervous system
What aer the two primary kinds of synaptic inputs in the cerebellum?
mossy fibers and climbing fibers
Where do mossy fibers arise from?
pontine nuclei and numerous regions
Where do mossy fibers synapse?
dendrites of granule cells
Where do granule cells synapse?
after bifurcating to form parallel fibers, synapse on numerous Purkinje cell dendrites, stellate cells, basket cells, and golgi cells
Are granule cells excitatory or inhibitory?
excitatory
What carries all outputs of the cerebellar cortex?
Purkinje cell axons into cerebellar white matter (to deep cerebellar and vestibular nuclei)
Where do Purkinje cells synapse?
deep cerebellar and vestibular nuclei
Are Purkinje cells excitatory or inhibitory?
inhibitory
Where do climbing fibers arise?
exclusively from neurons in the contralateral inferior olivary nucleus
Where do climbing fibers synapse?
they wrap around the cell body and proximal dendritic tree, forming powerful excitatory synapses on 10 Purkinje cells
What is the effect of climbinging fibers?
excitatory, having a strong modulatory effect on the response of Purkinje cells, causing a sustained decrease in their response to synaptic inputs from parallel fibers
How many climbing fibers is each Purkinje cell excited by?
only 1, although each climbing fiber synapses with about 10 Purkinje cells
Are climbing fibers excitatory or inhibitory?
excitatory
Where are basket cells located?
molecular layer
Where are stellate cells located?
molecular layer
Where do stellate cells terminate?
Purkinje cell dendrites in the molecular layer
What is the affect of stellate cells?
lateral inhibition of adjacent Purkinje cells (narrow the spatial extent of excitatory inputs to Purkinje cells - enhanced signal resolution in the spatial domain)
Are stellate cells excitatory or inhibitory?
inhibitory