Neuro Anesthesia Part 2 Flashcards
Craniotomy
Presentation/Diagnosis
* 40 to 60 years of age
* signs and symptoms reflecting increasing ICP (intracranial pressure)
* adult onset seizure disorder
* CT or MRI
Types of tumors & locations
not on test
Grading: I & II
Grade I
The tumor grows slowly, has cells that look similar to normal cells, and rarely spreads into nearby tissues. It may be possible to remove the entire tumor by surgery.
Grade II
The tumor grows slowly, but may spread into nearby tissue and may become a higher-grade tumor.
Grade III and IV
Grade III:
The tumor grows quickly, is likely to spread into nearby tissue, and the tumor cells look very different from normal cells.
Grade IV:
The tumor grows very aggressively, has cells that look very different from normal cells, and is difficult to treat successfully.
Grading…
The chance of recovery (prognosis) and choice of treatment depend on the type, grade, and location of the tumor and whether cancer cells remain after surgery and/or have spread to other parts of the brain
Meningioma
- 12-20% of all primary brain tumors
- the meniges are 3 membranes that cover the brain and spinal cord
- usually benign, arises from the meninges of the brain and spinal cord
- most common in middle-aged adults, esp women
Meningioma
- 12-20% of all primary brain tumors
- the meniges are 3 membranes that cover the brain and spinal cord
- usually benign, arises from the meninges of the brain and spinal cord
- most common in middle-aged adults, esp women
- The M & M rate of meningiomas are difficult to assess accurately.
- Some are discovered fortuitously when a CT scan or MRI is done for unrelated diseases or conditions.
- Thus, some patients die with their meningioma and not secondary to it.
Morbidity and Mortality
Factors that may predict a higher postoperative morbidity rate:
* patient-related factors
* advanced age
comorbid states: DM/CAD/Altered LOC
Tumor factors
* location / size / vascularity of tumor
* neural involvement
* prior surgery &/or radiotherapy
Sequencing
Preoperative Evaluation…
Preparation of Patient: Monitors…
Induction of Anesthesia…
Mayfield pin placement…
Positioning of the patient…
Mannitol, Decadron, I-stat & Glucose …
Maintenance of Anesthesia…
Emergence…
Evidence of intracranial hypertension:
- nausea and vomiting
- hypertension
- bradycardia
- personality change
- altered level of consciousness
- altered pattern of breathing
- papilledema
- seizures (levels)
MRI - midline shift
Midline shift > 5 mm and/or encroachment on CSF cisterns suggest intracranial hypertension
Avoid preop pharmacologic sedation and ventilatory depression
Blood Diversion Phenomenon
Inverse Steal/Robin Hood Phenomenon- Vasoconstriction of normal vessels but not in ischemic areas (d/t vaso motor paralysis).
This is one reason we hyperventilate pts. w/ tumors and increased ICP.
Luxury perfusion- BAD-Perfusion in excess of metabolic needs. Vasodilatation to surrounding tissues. AKA
*Circulatory/Cerebral Steal phenomenon- *
localized ischemic areas are already maximally dilated . It you further dilate surrounding vessels, you “steal” blood flow to other areas of the brain away from the ischemic area…
CBF Curve
Choice of inhalational agent
Inhalational Agents:
decrease CMRO2
> 0.6/1.0 MAC leads to cerebral vasodilation & dose-dependent increases in CBF
vasodilation greatest with: halothane > isoflurane >desflurane >sevoflurane
Nitrous Oxide
Effects are generally mild & easily overcome by other agents or changes in CO2 tension…
Combined with other IV agents: N2O has minimal effects on CBF, metabolic rate, & ICP
Controversial…
Adding Nitrous Oxide to a VA, can further increase CBF
When given alone, mild cerebral vasodilatation with the potential to increase ICP
Ketamine
Generally increases CMRO2 & CBF
**If **PaCO2 maintained normal in presence of elevated ICP or cerebral trauma, then ketamine does not adversely alter CBF or ICP
Thiopental
Four Major Actions on the CNS:
1. Hypnosis
2. Anticonvulsant
3. Decreases CMRO2
4. Decreases CBF due to increased cerebral vascular resistance CBF, and ICP
Propofol
- Decreases CMRO2, CBF, and ICP
- Excessive hypotension & myocardial depressant effects can compromise CPP
- decreased MAP leads to decreases CPP
- Although administration has been associated with dystonic & choreiform movements, it has significant anticonvulsant activity
Etomidate
Decreases CMRO2, CBF, and ICP
Decreases CSF production & enhances absorption
Concern over adrenal suppression limits its long term use
Induction: myoclonic movements
Increases EEG activity ONLY in pts. With a history of epilepsy
Opioids
- Opioid induced increases in ICP due to decreased MAP can be avoided simply by controlling MAP during opioid administration.
- As a result, opioids are unlikely to be an issue during maintenance with respect to brain bulk.
- Depress ventilation, increasing PaCO2 leading to increases in CBF and ICP
Steroids
Dexamethasone (Decadron): Postulated mechanisms of action of corticosteroids in brain tumors include:
1. reduction in vascular permeability (cytotoxic effects of tumors)
2. inhibition of tumor formation
3. decreased CSF production
Acute Post-craniotomy Emesis
Occurs in approximately 50% of patients
Appears to be largely prevented by ondansetron 4mg administered near the time of dural closure…
This statement is substantiated by research performed at Duke University Medical Center…
*Canadian Journal of Anesthesia. 51:326-341:2004
Evidence-based management of postoperative nausea and vomiting: a review
Journal of Neurosurgical Anesthesiology. 14(2):102-107, April 2002.
A randomized, double-blind comparison of ondansetron versus placebo for prevention of nausea and vomiting after infratentorial craniotomy.*
Anesth Analg 2000;91:358-361
A Randomized, Double-Blinded Comparison of Ondansetron, Droperidol, and Placebo for Prevention of Postoperative Nausea and Vomiting After Supratentorial Craniotomy
Craniotomy-associated Chronic Emesis
Little is known about prevalence or treatment…
What we do know is it is Life-threatening…
J Neurosurg 102:547-9, 2005
“Responsiveness of Life-threatening refractory emesis to gabapentin-scopamine therapy following posterior fossa surgery: Case Report”
Monitors
Standard plus: arterial line, 2 large bore IV’s
Sitting position/Aneurysm/AVM:
- CVP catheter/long arm
Additional monitoring if PMH warrants
Induction of Anesthesia
STP, propofol, or etomidate
Prompt induction without ICP elevation
Muscle relaxant to facilitate endotracheal intubation & mechanical hyperventilation (BEWARE: coughing causes marked increases in ICP)
Succinylcholine does not significantly alter CBF or ICP in patients with neurological injury…
Pressure-Volume (Elastance) Curves
Elastance = change in pressure /
change in volume
When intracranial compensatory mechanisms are exhausted, small changes in volume lead to dramatic changes in ICP
Mayfield Pin Placement
Goal: Not to have large hemodynamic swings in blood pressure.
Increase with insertion & then decrease after due to the fact you administered a longer acting agent and now there is “down time”…
No one way is “perfect”
Know that your SBP will predictably rise ~40mmhg
Therefore need to lower b/p…
Do NOT let them start until you do this…
AND do NOT lower the b/p UNTIL they have pins in hand ready to go…
What does the evidence reveal & what do I do…
Research related to Mayfield Pin Placement…
“The effect of skull-pin insertion on cerebrospinal fluid pressure and cerebral perfusion pressure: influence of sufentanil and fentanyl”
Conclusion:
In anesthetized patients, an intravenous bolus of fentanyl(4.5 mcg/kg) or sufentanil (0.8mcg/kg) prior to skull-pin insertion results in stable values of CSFP, CPP, BP, and HR… The b/p was modified with phenylephrine / atropine were indicated
Pin Placement management
Minimum of 4 mcg/kg Fentanyl
Titrate Iso to NO more than 1.0 MAC
Propofol 1mg/kg, titrated to response
Esmolol/Ntg – Only if necessary
Lower SBP by ~40mmg
Consider Lidocaine*
PIN Placement
Lower Iso, Propofol, NTG effects gone…
B/P Normalizes