Neuro Flashcards
Appearance of cytotoxic edema?
Causes?
- Loss of greywhite differentiation
- Infarction
- Hypoxic injury
- HSV encephalitis
Appearence of vasogenic edema?
Cause?
- White matter only becomes hypodense
- Malignancy (primary or secondary)
- Abscess
What is the cellular etiology for cytotoxic edema?
- Failure of N/K pump
What is the cellular etiology for vasogenic edema?
BBB breakdown
How is area at risk defined on CT perfusion?
Time to maximal perfusion (Tmax) > 6.0s
How is the area of infarct core defined on CT perfusion?
Volume of brain tissue with cerebral blood volume <30% of the contralateral side.
How is penumbra defined on CT perfusion?
Brain volume with Tmax > 6.0s - Brain volume with cerebral blood flow <30% = penumbra volume
Whats the next step if vasogenic edema is spotted on a noncontrast head CT?
Give IV contrast to check for tumor or abcesss
Whats the classic appearance of abscess on contrast enchanced T1 and DWI?
Rim enhancement with central non-enhancing pus which is bright on DWI.
What is the classic territory of involvement of HSV encephalitis?
Temporal horn and insula sparing the basal ganglia
A perfectly round brain parenchymal hemorrhage should make you suspicious of what?
a metastasis that has bled into itself
How do you differentiate a primary vs secondary intraaxial bleed?
- Primary bleed will have very little vasogenic edema. A secondary bleed will have large amount of vasogenic edema secondary to the primary lesion.
- Irregular shape - primary
- Round - secondary
What are the most common locations for hypertensive headahce?
- Basal ganglia (putamen)
- Thalamus
- Pons
- Cerebellum (dentate nucleus)
What is a lobar intracranial hemorrhage ?
Superficial bleed involving within the lobes of the brain (i.e. not the basal ganglia) which is strongly associated with amyloid angiopathy in the elderly
What the etiology of lobar hemorrhage in a young person?
AVM