neuro Flashcards
RFs subarachnoid haemorrhage
PKD smoking alcohol HTN cocaine connective tissue disesase: Marfan's, Ehlers-Danlos
thunderclap heaedache
subarachnoid
high impact trauma → brain haemorrhage
extradural
oculomotor nerve palsy presentation
eye "down + out" ptosis dilated pupil (mydriasis)
horner’s syndrome presentation
ptosis (partial)
constricted pupil (miosis)
anhydrosis
same side as lesion
cerebellar signs
ipsilateral dysdiadochokinesia + dysmetria ataxia nystagmus intention tremor slurred staccato speech hypotonia
presentation parkinson’s disease
bradykinesia resting pill-rolling tremor stooped posture cogwheel rigidity hypomimesis
CT scan lenticular vs crescent shape hyperdensity
lenticular = extradural crescentic = subdural
UMN signs
weakness
hyperreflexia (Babinski’s, clonus)
hypertonia (spasticity)
LMN signs
weakness + wasting hyporeflexia hypotonia flaccidity fasciculations
facial nerve palsy presentation
idiopathic LMN facial nerve palsy
facial weakness (NOT forehead sparing), drooling
hyperacusis (stapedius paralysis)
loss of taste (anterior 2/3 of tongue)
inability to close eye (tearing / drying)
loss of corneal reflex
Bell’s phenomenon: eyeball rolls up but eye remains open when trying to close eyes
normal sensation
myasthenia gravis vs lambert eaton
MG: muscle fatigue w use
ocular involvement
assoc w thymoma
AChR Ab
LE: may have autonomic involvement
anti-VGCC Ab
assoc w small cell lung cancer
investigations multiple sclerosis
bloods: FBC, ESR / CRP, LFTs, U+Es, B12
Gadolinium enhanced MRI brain + spinal cord (gold standard)
lumbar puncture → electrophoresis → IgG Ab in CSF form oligoclonal bands
visual evoked potentials → delayed conduction velocity
causes of parkinson’s plus
Lewy body dementia multiple system atrophy progressive supranuclear palsy corticobasal degeneration vascular parkinsonism
Parkinson’s disease management
medical:
dopamine agonists e.g. bromocriptine
L-dopa e.g. sinemet + domperidone / carbidopa (reduce peripheral SEs e.g. N&V)
COMT / MAO-B inhibitors (dopamine degrading enzymes)
surgical: deep brain stimulation
causes of cerebellar syndrome
demyelination: MS
alcohol
infarct: stroke / TIA
space-occupying lesion e.g. vestibular schwannoma
inherited: Friedrich’s ataxia, wilson’s disease
epilepsy medication: phenytoin
multiple system atrophy
management multiple sclerosis
conservative: MDT approach, stress reduction, smoking cessation, pt education
medical:
acute: IV methylprednisolone 3-5days
relapse prevention (disease modifying drugs DMDs): β-IFN, biologics (natulizumab, rituximab), mitoxantrone
symptomatic:
spasticity: baclofen / botox
urinary: CISC, anti-Ach (oxybutynin)
neuropathic pain: gabapentin
depression: SSRIs, psychological therapies
classification multiple sclerosis
progressive relapsing (pt declines w each relapse) secondary progressive (relapse / remission ends and pt suddenly declines) primary progressive (no relapse / remission) 80% relapsing-remitting (relapses may or may not leave permanent deficits) clinically isolated syndrome (1st episode + signs consistent w MS on MRI)
2 main types of stroke + RFs for each
ischaemic: embolic / small or large vessel atherosclerosis
haemorrhagic: HTN, aneurysm / AVM rupture, trauma, altered haemostasis
acute management stroke
urgent CT head → exclude haemorrhage
ischaemic:
< 4.5hrs (hyperacute) → thrombolysis: IV alteplase
consider thrombectomy <6hrs for severe stroke
> 4.5hrs → aspirin 300mg (2nd line clopidogrel)
repeat CT after 24hrs to reconfirm no haemorrhage
haemorrhagic:
refer to neurosurgery for coiling of aneurysms / decompressive hemicraniectomy
ongoing management post-stroke
cons: MDT approach (incl. SALT swallow assessment)
RF modification: exercise, diet, smoking cessation
medical:
antiplatelet therapy: clopidogrel
if AF → warfarin (start after 2wks)
manage CV RFs: statin, anti-HTN, treat diabetes
surgical: endovascular stenting, carotid endarterectomy (stenosis > 70%)
management TIA
all pts seen within 7 days
if ABCD2 score (risk of stroke) > 3 → see within 24hrs
cons: RF modification
med: RF modification (treat HTN + diabetes)
statin + clopidogrel 75mg OD
warfarin if AF
surg: carotid endarterectomy: if stenosis > 70%
corticospinal tract function
descending tract
motor
pyramidal decussation in medulla
spinothalamic tract function
ascending tract
pain, temperature
decussates at level of innervation
dorsal columns function
ascending tract
light touch, proprioception, vibration
decussation in medulla
presentation anterior cord syndrome (Beck’s)
preservation of dorsal columns (light touch, proprioception, vibration)
loss of spinothalamic (temperature, pain) contralateral
UMN signs below lesion
LMN signs at level of lesion
presentation Brown-Sequard
hemisection of spinal cord
ipsilateral motor UMN signs below lesion / LMN at level of lesion
ipsilateral loss of light touch, proprioception, vibration
contralateral pain / temp loss (spinothalamic)
presentation central cord syndrome
central corticospinal damage → motor loss affecting arms > legs
spinothalamic + dorsal tract damage → loss of pain, temp, proprioception, light touch, vibration
cauda equina presentation
back pain / sciatica areflexia (ankle jerk) flaccid LL weakness saddle anaesthesia bowel / bladder dysfunction
investigations for guillain barre
bloods: FBC, CRP / ESR, culture → infection
stool MC+S → infection
antiganglioside Ab
imaging to exclude other problems
lumbar puncture → raised CSF protein, normal WCC
spirometry → reduced FVC
nerve conduction studies → reduced velocity
typical Hx extradural haemorrhage
head trauma (pterion) blackout on impact, lucid interval, deterioration
typical Hx subdural haemorrhage
fluctuating consciousness
alcoholics / elderly (brain atrophy pulls on venous sinuses)
source of bleed in extradural haemorrhage
middle meningeal artery (beneath pterion)
differentials for tremor
resting tremor: parkinsonism, benign essential tremor, drugs e.g. antipsychotics, beta-agonists
intention tremor: cerebellar syndrome
postural tremor:
thyrotoxicosis, caffeine, anxiety, same drugs as above
typical presentation lewy body dementia
visual hallucinations
fluctuating memory problems / cognitive impairment
parkinsonism
causes of unilateral ptosis
Horner’s (constricted pupil, partial ptosis)
oculomotor nerve palsy (dilated pupil, complete ptosis)
stroke
myaesthenia gravis
congenital e.g. simple congenital myogenic ptosis, myotonic dystrophy
causes of bilateral ptosis
myaesthenia gravis
guillain-barre syndrome
myotonic dystrophy
innervation of upper limb reflexes
biceps: C5/6
triceps: C7
supinator: C6
reflex grading
0 = absent 1+ = present only w reinforcement 2+ = normal 3+ = hyperactive w/o clonus 4+ = hyperactive w clonus
MRC power scale
0 No contraction
1 Flicker or trace of contraction
2 Active movement, with gravity eliminated
3 Active movement against gravity
4 Active movement against gravity and resistance
5 Normal power
innervation of lower limb reflexes
patellar: L3-4
achilles: S1-2
lower limb + upper limb dermatomes
upper: C5, C6, C7, C8, T1
lower: L1, L2, L3, L4, L5, S1
definition myaesthenia gravis
autoimmune neuromuscular disease w Ab against AchR (affects postsynaptic membrane of NMJ)
investigations myaesthenia gravis
bloods: CK (exclude myopathy), AchR Ab, MuSK Ab, anti-VGCC Ab (Lambert-Eaton), TFTs
Tensilon test: trial short acting anticholinesterase → ↑ACh → transient symptom improvement
lung function testing → reduced FVC
CXR / CT thorax → exclude thymoma / lung Ca
nerve conduction testing → reduced muscle action potential with stimulation
EMG → ↓response to repetitive stimulation →↑single-fibre jitter
management acute myaesthenic crisis
ABCDE
IVIg / plasmaphoresis
prednisolone
monitor FVC → intubation / ventilation