Neuro Flashcards

1
Q

In what trimester is the neuro system formed in utero?

A

1st trimester

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2
Q

Until what age are the number of glial cells and dendrites developing?

A

4yo

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3
Q

Until what age is the brain growing?

A

Puberty

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4
Q

In what direction does myelination occur?

A

Head to toe (cephalocaudal)

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5
Q

What are the primititve reflexes?

A

Rooting, Babinski, Moro, Palmar grasp, Fencing

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6
Q

What is the rooting reflex?

A

Babies turn face towards a stimulus and start rooting/sucking.

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7
Q

What is the Babinski reflex?

A

When foot is firmly stroked, toes flex outwards.

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8
Q

What is the Moro reflex?

A

When baby feels as if it is falling, extremities fan out.

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9
Q

What is the palmar grasp reflex?

A

When something is placed in newborn’s hand, baby will grasp that object.

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10
Q

What is the fencing reflex?

A

When a baby’s head is turned to one side, the arms and leg of that side are extended and the arms and legs of the opposite side are flexed.

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11
Q

When does the posterior fontanel close?

A

3mo

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12
Q

When does the anterior fontanel close?

A

18-24mo

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13
Q

What are possible causes of altered LOC?

A

Hypoxia, trauma, infection, poison, shunt malfunction, seizure, balance disturbances (endocrine, metabolic, electrolyte, acid/base), CNS disorders, structural defects

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14
Q

What is decorticate posturing?

A

A position that may indicated altered LOC d/t injury ABOVE brainstem, extremities brought to the “core” (brought in tight)

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15
Q

What is decerebrate posturing?

A

A position that indicates altered LOC d/t injury BELOW the brainstem, extremities splayed outwards.

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16
Q

What are the early s/s of increased ICP?

A

HA, visual changes, N/V, dizziness, pupils, sunsetting eyes, seizures, bulging fontanel

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17
Q

What are the three categories of the GCS?

A

Eyes, verbal, motor.

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18
Q

What is the most common neuro dysfunction in kids?

A

Seizures

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19
Q

What are idiopathic seizures?

A

Seizures with unknown cause (not epileptic)

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20
Q

What is the major cause of seizures in newborns?

A

Birth injury (anoxia) or congenital CNS defects

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21
Q

What is the major cause of seizures in infants?

A

Infection

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22
Q

What are absence seizures?

A
  • AKA petit mal
  • Brief loss of consciousness
  • No change in muscle tone
  • Onset @ 4-12yrs
  • No aura
  • Lasts 5-10sec
  • S/s = lip smacking or twitching of eyes
  • Minimal risk of falling
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23
Q

What are atonic seizures?

A
  • Sudden loss of muscle tone
  • Onset @ 2-5yrs
  • Possible loss of consciousness
  • Risk of falling (helmet worn often)
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24
Q

What are myoclonic seizures?

A
  • Contractions of muscles
  • No loss of consciousness
  • Often occurs when falling asleep
  • May be mistaken for exaggerated startle reflex (test if head can flex, if cannot, may be a myoclonic sz)
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25
Q

A child is wearing a helmet for seizures, what seizures are they most likely experiencing?

A

Atonic

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26
Q

What type of seizures occur most frequently when falling asleep?

A

Myoclonic

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27
Q

What are the 3 types of epilepsy?

A

Partial (focal) seizures, generalized, and ideopathic

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28
Q

At what age does epilepsy typically manifest?

A

5-6yrs

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29
Q

What is partial epilepsy?

A
  • No loss of consciousness
  • Sz lasts 30sec
  • Sz occur at any time of day
  • Motor responses involve =1 extremity
  • Can progress to general
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30
Q

What is status epilepticus?

A

Acute sz that lasts >30min (despite medical intervention)

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31
Q

What steps are taken during status epilepticus?

A
  • Maintain airway
  • Check electrolytes, glucose, blood gases, temp, BP
  • Administer meds
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32
Q

When can a bite block be used during a seizure?

A

If placed before seizure begins (during aura)

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33
Q

If IV access isn’t available, how can meds be given during status epilepticus?

A

Rectal valium

34
Q

What is the ceiling dose for anti-epileptic meds?

A

None. AEs = RR depression, can maintain respiratory but key is stopping seizure

35
Q

What meds may be used during status epilepticus?

A

Benzos = Valium (rectal or IM) + Ativan + Versed (intranasal); Anticonvulsant = phenytoin (IV)

36
Q

What labs need to be considered for seizure disorders?

A

Glucose, BUN, Ca+2, Na+

37
Q

What diagnostic tests are performed to assess a seizure disorder?

A

EEG, MRI (brain lesions), LP (meningitis)

38
Q

What are common pediatric seizure triggers?

A

Changes in dark-light patterns, loud noises, extreme temp changes, dehydration, fatigue.

39
Q

What age most commonly experiences febrile seizures?

A

6mo-5yr

40
Q

What gender is more likely to experience febrile seizures?

A

Male

41
Q

Are febrile seizures related to the extremity of the temperature or the rate of temp change?

A

Rate of change

42
Q

What is done to tx febrile szs?

A
  • Tx ongoing seizure (Diazepam, rectal)
  • Protect head from injury
  • Call 911 if lasts >5min
  • Reduce fever
  • Evaluate hx for prior sz
43
Q

How do you prevent febrile szs?

A
  • Vigorous tx of fever w/ antipyretics (tylenol, NOT aspirin)
44
Q

What is the “5th day fit”?

A

When dosing long-term phenobarbital for sz control, 5th day fit = random seizure on 5th day of tx after period w/o seizures

45
Q

What is the first line drug for febrile and neonatal seizures?

A

Phenobarbitol (GABAA and Ca+2 channel antagonist)

46
Q

Which anti-sz drug can not be mixed with glucose (D5W, etc.)?

A

Phenytoin (blocks Na+ channels)

47
Q

What is an AE to phenytoin to be aware of?

A

Gingival hyperplasia (gum overgrowth); tx w/ soft toothbrush and regular oral care

48
Q

What is fosphenytoin?

A

A version of phenytoin that can be given with glucose

49
Q

What is a dangerous side effect of valproic acid?

A

Hepatotoxicity (secondary to long-term use); monitor serial LFTs

50
Q

What is the med of choice for status epilepticus?

A

Diazepam (rectally)

51
Q

Which anti-sz meds can be given via IV?

A

Phenobarbital, phenytoin, fosphenytoin, valproic acid, diazepam.

52
Q

What are the side effects of phenytoin?

A

Gingival hyperplasia *, rashes, acne, hirsutism, osteoporosis

53
Q

Which anti-sz meds can be given PO?

A

Phenytoin, valproic acid.

54
Q

Which anti-sz meds can be given IM?

A

Fosphenytoin, diazepam.

55
Q

Which anti-sz med can be given intranasally?

A

Midazolam (Versed)

56
Q

When are anti-sz meds discontinued?

A
  • Seizure free for 2yrs

- Normal EEG

57
Q

Why should anti-sz meds be weaned?

A

Abrupt cessation can trigger bad seizures

58
Q

When should anti-sz meds not be stopped?

A

During puberty

59
Q

What are the components of a seizure assessment?

A
  • WATCH THE CLOCK
  • Airway
  • Maintain safety
  • VS
  • Neuro assessment (pupils, etc.)
60
Q

What education should be given for a child with a seizure disorder?

A
  • Get enough sleep
  • Do not swim alone
  • Limit activity during start of new long-term med
  • Wear ID bracelet
61
Q

What are the s/s of bacterial meningitis in an infant?

A
  • Fever
  • Bulging fontanel
  • Changes in feeding
  • Vomitting
  • Diarrhea
  • Irritable
  • Lethargic
62
Q

What are the s/s of bacterial meningitis in a child?

A
  • Fever
  • Altered LOC
  • Muscle/joint pain
  • URI or GI
  • Irritability
  • Vomit
63
Q

What do you assess for with bacterial meningitis?

A
  • Petechiae (purpura of BLE)
  • HA
  • Photophobia
  • Nuchal rigidity
  • Sz
  • DIC (excess coagulation)
  • Shock
64
Q

How do you assess nuchal rigidity?

A
  • Kernig’s sign (flexing of leg)

- Brudzinski sign neck flexing causes legs to flex)

65
Q

How is bacterial meningitis transmitted?

A

Droplet

66
Q

How is bacterial meningitis definitively diagnosed?

A

LP

67
Q

How is bacterial meningitis of treated?

A

Antibiotics

68
Q

What are the s/s of viral meningitis?

A

Same as bacterial but less severe:

  • Petechiae (purpura of BLE)
  • HA
  • Photophobia
  • Nuchal rigidity
  • Sz
  • DIC (excess coagulation)
  • Shock
69
Q

What is the role of antibiotics with viral meningitis?

A

Antibiotics are dosed until bacterial meningitis can be definitively be ruled out.

70
Q

What is encephalitis?

A

Inflammation of CNS leading to altered brain and spinal cord function.

71
Q

What are the vectors of encephalitis in the US?

A

Ticks and mosquitoes

72
Q

What are the s/s of encephalitis?

A

Bacterial meningitis + speech difficulties

73
Q

What are the s/s of severe encephalitis?

A
  • High fever
  • Occular palsies (1 sided paralysis)
  • Disorientation
  • Coma
  • Seizures
  • Paralysis
74
Q

What tests are diagnostic of encephalitis?

A
  • LP

- EEG

75
Q

How is encephalitis tx?

A

Symptom management (fluids, fever reduction, pain control, seizure control and prevention)

76
Q

How do you differentiate between encephalitis or meningitis?

A

Assess for meningeal irritation- Kernig’s or Brudzinski’s signs

77
Q

What are examples of structural neuro defects?

A
  • Microcephaly
  • Hydrocephalus
  • Carniosynostosis
  • AV malformations
78
Q

What is craniosyntosis?

A

Skull plates misalign and fuse

79
Q

What is AV malformation?

A

Atrial and ventricle miscommunication

80
Q

What are the s/s of AV malformation?

A

Initially asymptomatic, then HA, sz, stroke