NEURO Flashcards
A pt with a tremor that occurs when their hand is outstretched or they go to reach for something, but not at rest, is known as what?
Essential tremor
What might a pt report with an essential tremor?
It is improved with alcohol
How do you treat an essential tremor?
Propranolol
What movement disorder is inherited, occurring at a younger age, with choeiform movements?
Huntington’s disease
A decrease in dopamine is associated with what movement disorder?
Parkinson’s
What are some of the sxs of Parkinson’s?
pill rolling (at rest or with intention), bradykinesia (slow movement), cogwheeling, masked facial expression, micrographia, stooped posture, shuffling gait
How do we treat Parkinson’s?
Anticholinergics, amantadine for older adults
Levodopa for advanced patients
*Start treatments when function is impaired
What is the most common form of dementia?
Alzheimer’s
What form of dementia has a slow/gradual onset, over 8-10 years?
Alzheimer’s
If a patient is having difficulties with memory, they can’t seem to learn new info but their motor and sensory function is spared – what disorder?
Alzheimer’s
What form of dementia has gradual onset, but also involves hallucinations, visuospatial fluctuations along with Parkinsonism?
Lewy Body dementia
Lewy body dementia is associated with what portion of the brain?
basal ganglia
If a patient is having difficulties with language and executive functioning – what disorder?
Frontotemporal dementia
If on MRI a pt has cortical & subcortical changes with sudden almost stepwise changes in function – what disorder?
Vascular dementia
What should be done on PE in a pt with dementia?
neuro exam, mental status, functional status (SLUMS, mini-cog, MMSE)
What’s the first question of a MMSE?
Orientation – what’s the year, season, month, date, day
What occurs in a mini-cog exam?
Remember/repeat 3 words Draw a clock with hands at a specific time Recall the 3 words
What type of labs should we order in a pt we suspect dementia?
CBC, Na, BUN/Cr, Fasting Glucose, RPR, TSH, B12
Possible UA, folic acid, and liver function
In a pt we suspect dementia, when would we consider imaging?
onset <65; focal sxs; concern from hydrocephalus; recent fall or head trauma
What are some non-pharm options for tx dementia?
cognitive rehab, therapy, physical & mental activity; attention to safety
What is being broken down too quickly with dementia?
Acetylcholine
What medications slow the breakdown of acetylcholine and are prescribed for dementia? Give some examples
Cholinesterase inhibitors
Ex: Donepezil or memantine
What should you always keep on your DDx in a patient you’re concerned has dementia, and thus we may treat them for this as well?
Depression
What disorder involves idiopathic demyelinating affecting the white matter of the CNS?
MS
Who is affected by MS, and how do we diagnose it?
Women and peaks in 20-30’s
Diagnosed by 2 or more clinically distinct episodes of CNS dysfunction separated by space and time
Motor dysfunction, diplopia, gait disturbance, bowel/bladder dysfunction, and sexual dysfunction
(Lhermitte sign = electric shock that runs down the spine and limbs with neck flexion)
How do we confirm diagnosis of MS?
clinical + MRI with gad to show cerebral or spinal plaques
LP shows oligoclonal bands
How do we treat MS?
Glucocorticoids (acute)
Interferon beta, glatiramer, natalizumab (chronic)
If there is a LOC with a seizure, what is it?
Generalized seizure (convulsive or not – absence)
If there is NO LOC with a seizure, what is it?
Simple partial seizure (jacksonian seizure)
Complex partial seizure (auras)
If a child is staring off into space, with moments of blankness, constant blinking or lip smacking – dx?
Absence (petite-mal) seizure
What is the temporary paralysis after a seizure known as?
Todd’s paralysis
How do we work-up a seizure?
Labs (CBC, electrolytes, glucose, Ca, Mg, renal function, and tox)
CT or MRI and EEG
How do we treat seizures? Who cannot take those medications?
carbamazeprine, phenytoin, and Valproate (valproic acid)
*women who are preggo, and those of child bearing age need extra folic acid
At what point do we prescribe anticonvulsant medications?
DO NOT USE in the setting of a single unprovoked seizure in a pt with a normal neurologic exam
How do we treat an absence seizure?
Ethosuximide
If the CT or MRI after a seizure is negative and no provoking stimuli is found, what dx?
Epilepsy
For status epilepticus what is the Tx?
- Lorazepam
- Phenytoic (valproic acid)
- Phenobarbital (propofol)
What are some of the risk factors to a stroke?
HTN!! (MOST POWERFUL RF)
Smoking; atherosclerosis elsewhere; DM; AFib
Other: male, ETOH, hyperlipidemia, AIDS, previous stroke
A lacunar infarct is occurring where? What type of sxs are associated with these?
SMALL VESSEL Disease
May be without findings – incidental on CT
A cerebral emboli stroke is what?
Embolism from heart or artery breaks off and occludes a distant vesselin the brain
What type of stroke is often associated with Afib and is the reason why it’s so important to anticoagulate pt’s with afib?
Cardioembolism
What artery is affected when a pt has contralateral hemiplegia (hemiparalysis) after a stroke?
Middle Cerebral Artery
What artery is most commonly occluded during a stroke?
Middle Cerebral Artery
If this artery is occluded during a stroke it can lead to loss of several reflexes (grasp, suck), paralysis of foot/leg, urinary incontinence, and behavioral changes.
Anterior Cerebral Artery
If an occlusion occurs in this area of the brain it will results in visual deficits and changes in pupils/sensations?
Posterior Circulation
If a pt has transient monocular blindness – what does that mean, what is it called?
Embolism of ophthalmic artery - Amaurosis Fugax
If it is an acute stroke, what imaging do you need? What are you ruling out?
CT scan
R/O Hemorrhage
After a CT scan what’s the next imaging needed? What’s technically the gold standard?
MRI
Gold Standard = Arteriography
During an acute stroke what do we do if their BP is 180/90?
LEAVE IT – avoid rapid BP reduction
During an acute stroke what do we do if their BP is 203/100?
Okay now you need to lower it – SLOWLY!
So, how do we treat an acute stroke?
Once hemorrhage has been ruled out…
<3 hours = TPA + full anticoagulation
What are contraindications to TPA?
Previous stroke or recent bleeding/major surgery BP >185/110 Neoplasm Glucose <50 & platelets <100,000 Heparin use within 48 hours
If the cause of a pts stroke is an embolus from the heart – how do we treat?
Full anticoag
What’s the difference between a stroke & TIA?
Stroke = sxs >24 hours, irreversible damage
TIA = sxs <24 hours, reversible
What surgical treatment is available for a TIA?
carotid endarterectomy or carotid angioplasty/stenting
What pharm Tx is available for TIA? When do we initiate it?
ASA
If Pt is a poor operative candidate, <70% stenosis
If a pt presents with fever, AMS, a stiff neck, HA, and photophobia – what do you think? What do you do on PE?
Meningitis
*Nuchal rigidity – KERNIG (supine, flex the knee, resistance to extend the knee)
BRUDZINSKI (supine, lifting the head causes the hip to flex)
In a pt you are concerned has meningitis also has petechial rash what do you think is the cause?
N. meningitis
How do you work up a pt you are concerned about meningitis?
CT
LP
If a LP shows WBC over 1,000, increased proteins, and decreased glucose – what do you think?
Meningitis
What is the MC cause of meningitis
Strep pneumo; Neisseria meningitides; HIB; Listeria
What type of bacteria would we see in a 50 y/o male with meningitis?
Listeria
What is the MC cause of meningitis in an infant?
Group B strep
How do we treat meningitis?
Emperically with dexamethasone, ceftriaxone, and vanco
What would you give a 50 y/o with meningitis?
Ampicillin
What can you not use in a child in the first month of life to treat meningitis?
Ceftriaxone
GIVE = ampicillin, cefotaxime, +/- genatmycin
How do we confirm cure of meningitis?
CSF re-test in 24 hours, should be clear
What would the CSF look like in viral meningitis?
More lymphs WBC less than 1,000 Protein and glucose are normal
How do we treat viral meningitis?
Supportive (cause is HSV)
What disorder causes unilateral facial paralysis where a pt cannot raise the eyebrow? Cause? Tx?
Bell’s Palsy Cause = herpes simplex virus Tx = course of oral prednisone to help with full recoverys, usually self-limiting
A pt presents with bilateral distal extremity weakness that ascends up the legs. It is somewhat painful and DTR’s a decreased. – Dx? Cause? Workup?
Guillian- Barre Campylobacter jejuni EMG and CSF (may see elevated proteins)
How do we treat guillian-barre?
Hospitalize pts to watch respiratory status Plasmapheresis ASAP or IVIG Rehab