neuro Flashcards

1
Q

key motor tests

A

Drift of upper extremity (and lower if necessary)
o Have pt. close eyes and hold arms horizontally forward, palm up for
15-30 sec
o If +, hand will drop and rotate in***
*often combined with rhomberg balance test

Hand grasp and toe dorsiflexion
o Weakness is commonly seen in upper motor neuron lesion
o Cross hands, have pt. grasp index and middle fingers
o Move toe and foot against resistance

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2
Q

Coordination, stance and gait tests

A
  1. Finger-to-nose and Heel-to-shin
    o Cerebellar lesions: awkwardness of movement
  2. Rapid alternating movements
    o Slowness may results from cerebellar lesion,
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3
Q

Balance tests

A
  1. Tandem gait (walk heel to toe) 2. Rhomberg
    o We all need 2 out of the following 3 senses to maintain balance • Vision
    • Vestibular sense
    • Proprioception
    o (+) test”pt sways when eyes are closed
    • either vestibular or proprioceptive defect
    o If pt. sways when eyes are open this is not a positive test and
    therefore suspect a cerebellar lesion
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4
Q

ROS HEENT

A
  1. Headache?
  2. Visual changes?
  3. dizziness
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5
Q

ROS neuro

A
  1. Tremor?
  2. Weakness or sensory loss?
  3. LOC?
  4. Motordysfunction
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6
Q

Mental status FOGS

A
  1. FamilyStoryofMemoryLoss
  2. Orientation
    o To precise time (month, day, year)
  3. GeneralInformation
    o e.g. Who are the president and vice president of the U.S.? 4. Spelling
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7
Q

Sensory Testing

A
Pain: Sharp and dull testing
Proprioception, stereogenesis, vibration
1. With pts. eyes closed, bend big toe up and down and then test vibration
with tuning fork
o Decreased proprioception in MS
Light touch
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8
Q

ReflexTesting

A
  1. Triceps
  2. Biceps
  3. Knee Jerk
  4. Ankle Jerk
  5. Babinski
    o + (abnormal dorsiflexion of the great toe and fanning of the other toes)” UMN lesion

Normal responses are symmetrical
Asymmetryisgenerallymorereflectiveofpathology

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9
Q

Tests for meningeal irritation (r/o meningitis or subarachnoid hemorrhage)

A
  1. Kernig
    o (+)”pain in low back on straightened lower extremity)
  2. Brudzinski
    o (+) “ flexion of the head results in marked neck pain and
    involuntary flexion of the hip and lower extremities
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10
Q

neuro Basic Labs

A

a. CBC
b. CMP
c. TSH
d. Bedside glucose***
consider:
Celiac (anti-gluten Abs, TTG)
Heavy metal testing (whole blood, hair analysis, urine with and without provocation)
Environmental testing for solvents, pesticides, etc

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11
Q

Imaging and further studies

A

a. Lumbar Puncture*
b. CT
*
c. MRI***
d. MRA
e. MRV
f. Echoencephalography
g. Cerebral Catheter angiography
h. Duplex Doppler Ultrasonography
etc. ..

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12
Q

Cerebrovascular Accident (Stroke)

A

Definition: sudden interruption of cerebral blood flow that results in neurologic deficit

i. Causes brain damage
ii. mc cause of neuro disability, 3rd mc cause of death

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13
Q

if anterior brain blood supply affected by stroke

A

(2/3 of the brain)

  1. Internal Carotid
  2. Strokes involving this blood supply to the brain typically have unilateral sxs
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14
Q

if Posterior Supply affected by stroke

A

(posterior portion of temporal and parietal lobes, brainstem, and cerebellum)

  1. Vertebrobasilar
  2. Strokes involving this blood supply to the brain can have unilateral or bilateral sxs and is more likely to affect consciousness
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15
Q

stroke Risk Factors

A

i. Prior stroke
ii. Older age
iii. family hx
alcohol, male, HTN, cigarettes, cholesterol?, DM…

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16
Q

S/SX of stroke

A

Sudden!

i. Numbness,weakness or paralysis of the contralateral limbs, face
ii. Aphasia
iii. Confusion
iv. Visual disturbances in one or both eyes
v. Dizziness or loss of balance and coordination
vi. Headache

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17
Q

ischemic stroke

A

80%
1. Thrombosis–sites of turbulent flow, branching
MC• Atherosclerotic plaques
LC vascular inflamm dt infection, hypercoagulable state

2.Emboli
MC: cardiac–atrital fib, post MI, prosthetic valves, etc
LC: fat emboli, air, venus clots thru patent foramen ovale

  1. Lacunar (small vessel dz)
    DM, poorly controled HTN
4. TIA (Transient Ischemic Attack)
internal carotid artery dz
sx < 1 hr
st precede stroke onset by days/months
often no brain damave
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18
Q

ssx embolic stroke

A

o Quicker onset of neurologic deficit: minutes
o Often during the day
o Headache may precede neurologic deficit

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19
Q

ssx thrombotic stroke

A

o Tend to occur during the night and are noticed upon first waking
o May have slower onset of sxs: over 24-48hrs (aka “evolving stroke” or “stroke in evolution”)
• Evolving stroke: Unilateral neurologic dysfunction often
beginning in one arm and then spreading ipsilaterally
• Extends without headache, pain or fever

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20
Q

ssx lacunar stroke

A

o Pure motor hemiparesis
o Pure sensory hemianesthesia
o Ataxic hemiparesis

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21
Q

dx imaging

A

o CT
• Done first to exclude intracerebral hemorrhage
o MRI
• Generally done 2nd; many smaller infarcts may only be found with MRI

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22
Q

stroke ddx

A
  1. Hypoglycemia
  2. Postictal paralysis
  3. Hemorrhagic stroke
  4. Migraine
  5. Tumor
  6. Systemic condition: Guillian Barre, Bell’s Palsy
  7. syncope
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23
Q

Intracerebral Hemorrhage

A
Definition: Focal bleeding from a blood vessel in the brain parenchyma
caused by HTN!
or...Arteriovenous Malformations (AVMs)
• Aneurysm
• Trauma
• Brain tumor
• Bleeding disorder
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24
Q

Intracerebral Hemorrhage ssx

A
Focal neuro deficit w/:
• Headache
• Nausea
• Impairment of consciousness
o Nausea
o Vomiting
o Delirium
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25
Q

ssx Intracerebral Hemorrhage in hemisphere

A

hemiparesis

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26
Q

ssxIntracerebral Hemorrhage in posterior fossa

A

Brain stem and cerebellar dysfunction

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27
Q

intracerebral hemorrhage ddx

A

DDX
o Ischemic stroke
o Subarachnoid hemorrhage o Hypoglycemia
o seizure

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28
Q

Subarachnoid Hemorrhage (SAH)

A

Definition: sudden bleeding into the subarachnoid space

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29
Q

SAH etiol

A

mc ruptured aneurysm

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30
Q

SAH ssx

A

Sudden severe headache with LOC
• Headache is severe; peaking within seconds!!!
o Severe neurologic deficits
o Seizures are possible
o No neck stiffness initially but chemical meningismus may appear with
vomiting

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31
Q

SAH dx

A

Non-contrast CT
( if negative, lumbar puncture)
• blood in CSF

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32
Q

SAH etiol

A

mc TRAUMA, or ruptured aneurysm

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33
Q

SAH PE

A
mild/moderate BP elev
temp elev
tachycardia
papilledema
retinal hemorrhage
global/focal neurpo ab.
34
Q

Intracerebral Hemorrhage

A

Definition: Focal bleeding from a blood vessel in the brain parenchyma
caused by HTN! or…Arteriovenous Malformations (AVMs)
• Aneurysm
• Trauma
• Brain tumor
• Bleeding disorder

35
Q

Intracerebral Hemorrhage ssx

A
Focal neuro deficit w/:
• Headache
• Nausea
• Impairment of consciousness
o Vomiting
o Delirium
36
Q

intracerebral hemorrhage ddx

A
DDX
o Ischemic stroke
o Subarachnoid hemorrhage
o Hypoglycemia
o seizure
37
Q

SAH PE

A
mild/moderate BP elev
temp elev
tachycardia
papilledema
retinal hemorrhage
global/focal neuro ab.
38
Q

Delirium

A
Typically caused by acute illness or drug toxicity
. Often reversible
any age, elderly more common
Worse at night***
mc causes: 
1. Drugs, particularly anticholinergics, psychoactive drugs, and opioids
2. Dehydration
3. Infection
39
Q

delerium S/Sx

A
difficulty focusing
variable conscioussness
confusion
changes in personality/affect
disorientation
hallucinations
40
Q

delerium DX

A
Required for Dx
1. Acute change in cognition 
2.inattention/ focus problem 
3. Plus one of the following:
o Disturbance of consciousness 
o An altered level of consciousness (eg, hyperalert, lethargic, stuporous, comatose) or disorganized thinking
41
Q

delerium PEs

A
Vitals
hydration status
potential infection
tremor/myoclonus (uremia, liver,drugs)
skin
Head and neck
Neuro
42
Q

delerium labs

A
First line :
CT/MRI
CBC, UA, 
CXR
electrolytes
CMP
drug screen
SECOND line:
LFTs,
thyroid and ANAs
B12
syphilis

THIRD line:
CSF, serum ammonia, heavy metals

43
Q

Dementia

A

a. Typically caused by anatomic changes in the brain
b. Slower onset
c. Typically irreversible

44
Q

MC causes of dementia

A
  1. Alzheimer’s Dementia
  2. Vascular Dementia
  3. Lewy Body Dementia and Parkinson Disease Dementia
  4. HIV-associated Dementia
  5. Frontotemoral Dementia
45
Q

reversible dementia conditions

A
o Structural Brain Disorders
• Normal Pressure Hydrocephalus
o Metabolic Disorders
 • Hypothyroidism • B12 deficiency
o Toxins
• Lead
46
Q

Dementia

A

a. Typically caused by anatomic changes in the brain
b. Slower onset
c. Typically irreversible
* **short term memory loss mc first sign

47
Q

dementia stages

A
  1. short term memory loss, difficulty withb ADL, may have apraxia, aphasia, may have personality changes
  2. inability to learn, recall new info, remote event memory impaired, loss of sense of time and place, need help with ADL
  3. cant walk, feed themselves, or do ADLS, incontinence, complete aphasia, death usually dt infection after become debilitated
48
Q

dementia labs

A
TSH
B12
CBC
LFTs
HIV/ RPR?
and
CT or MRI
49
Q

distinguish dementia from the following:

A
  1. Delirium
  2. Age-associated memory impairment
  3. Mild cognitive impairment
  4. Cognitive sxs related to depression
50
Q

Dx of dementia

A

requires:
Cognitive or behavioral symptoms interfere with ADL
o These symptoms represent a decline from previous levels of functioning.
o symptoms not explained by delirium or a major psychiatric disorder.

> 2 of the following:
Impaired ability to acquire and remember new information (amnesia)
o Language dysfunction (aphasia)
o Visuospatial dysfunction
o Impaired executive function, including reasoning, handling ofcomplex tasks, and/or judgment (apraxia)
o Changes in personality, behavior, or comportment.

51
Q

Alzheimers Dz

A

Progressive cognitive deterioration caused by β-amyloid deposits and neurofibrillary tangles in the cerebral cortex and subcortical gray matter.

β-amyloid is formed during the processing of amyloid precursor protein (APP) (extracellularly)

2 known membrane-bound proteins called presenilins also contribute to APP processing: presenilin 1 and presenilin

MC cause of dementia

52
Q

Neurofibrillary tangles

A

Number and distribution of tangles is directly related to the
severity of the dementia

Consist of a microtubule-associated protein, tau (maintains neuronal cytoskeleton) and is change din AD

53
Q

Alzheimers DX criteria

A
  • Dementia established clinically and documented by
    a formal mental status examination
    *Deficits in ≥ 2 areas of cognition
    *Gradual onset and progressive worsening of memory and other cognitive functions
    *No disturbance of consciousness
    *Onset after age 40, most often after age 65
    *No systemic or brain disorders that could account for the progressive deficits in memory and cognition
54
Q

Vascular Dementia

A

Acute or chronic cognitive deterioration due to diffuse or focalcerebral infarction most often related to cerebrovascular disease (CVD)
2nd mc dementia type

exaggerated DTRs UMN!
gait
weakness
hemipelagias
pseudobulbar palsy
55
Q

vascular dementia risk factos

A
HTN
• DM
• Hyperlipidemia
• Smoking
• Hx of Several strokes
56
Q

types of vascular dementia

A

Multiple lacunar infarction
o Multi-infarct dementia
o Strategic single-infarct dementia
o Binswanger dementia (subcortical arteriosclerotic encephalopathy)

57
Q

Lewy Body dementia and ssx

A

characterized by cellular inclusions, called
Lewy bodies, in the cytoplasm of cortical neurons

Cognitive and extrapyramidal sxs usually begin within 1 year of each other (unlike Parkinson Dementia).
Fluctuating cognitive function
deficits summetric

58
Q

Parkinson dz dementia

A

Parkinson Disease (PD) is typically characterized as a movement disorder but dementia can form late in the disease.
Dementia is from Lewy bodies in the substantia nigra
3rd mc dementia, >60 yo

59
Q

parkinson dz ssx

A

Cognitive sxs don’t begin until 10-15 years after motor sxs
• Psychiatric sxs (hallucinations, delusions) less frequent than
Lewy Body dementia

60
Q

Lewy Body Probable if 2 of 3 are present:

A
  • Fluctuations in cognition
  • Visual hallucinations
  • Parkinsonism
61
Q

parkinson dz demenita more probable if

A

motor sxs are more severe and precede

cognitive sxs

62
Q

parkinson dz ssx

A

Cognitive sxs don’t begin until 10-15 years after motor sxs

• Psychiatric sxs (hallucinations, delusions) less frequent than Lewy Body dementia

63
Q

parkinson dz demenita more probable if

A

motor sxs are more severe and precede
cognitive sxs

Definitive Diagnosis requires autopsy samples of brain tissue

64
Q

HIV associated dementia

A

Chronic cognitive deterioration due to brain infection by HIV
affects younger people***
can be causes by opportunistic infection seocndary to HIV

65
Q

Frontotemporal Dementia

A

poradic, hereditary disorders that affect the frontal and temporal lobes, including Pick Disease

66
Q

frontotemporal dementia etiol

A

10% of all dementias
o Typically younger (avg. 55-65)
o Affects men and women equally o Family hx present in 50% of cases

67
Q

frontotemporal dementia pathophys

A

gliosis. neuronal loss, spongioform degeneration in the
superficial layers of the frontal and temporal lobes
Pick cells (large ballooned neurons) in

68
Q

Pick cells/bodies

A

• Pick bodies are round cytoplasmic inclusions that form in small neurons and are pathognomonic for Pick Disease if found in the dentate gyrus
***usu seen in frontotemporal dementia

69
Q

frontotemporal dementia ssx

A

Affects personality, behavior, and usually language function more and memory less than AD (striking behavioral and personality changes)
• Major breakdown in social behavior, personal hygiene and affect

MRI
• May show severely thin atrophy in frontal and temporal lobes

70
Q

Normal pressure hydrocephalus

A

defect in CSF resorption by arachnoid granulations

71
Q

frontotemporal dementia ssx

A

Affects personality, behavior, and usually language function more and memory less than AD (striking behavioral and personality changes)
• Major breakdown in social behavior, personal hygiene and affect

MRI
• May show severely thin atrophy in frontal and temporal lobes (late in dz)

72
Q

normal pressure hydrocephalus ssx

A

Gait disturbance (Magnetic gait (feet appear stuck to the floor is consideredcharacteristic)
o Urinary incontinence
o Dementia
o Enlarged brain ventricles
o Normal or slightly elevated CSF pressure

CSF
• Reveals normal to slightly elevated pressure

73
Q

normal pressure hydrocephalus ssx

A

Gait disturbance (Magnetic gait (feet appear stuck to the floor is consideredcharacteristic)
o Urinary incontinence
o Dementia
o Enlarged brain ventricles
o Normal or slightly elevated CSF pressure

CSF
• Reveals normal to slightly elevated pressure
super enlarged ventricles

74
Q

Spinocerebellar tract:

A

receives afferent info from the periphery

o Tracts come from the same side and do not cross

75
Q

Ascending Tracts (Sensory)

A

3 main sensory systems entering the spinal cord
• Pain-temperature
• Proprioception—stereognosis
• Light Touch

76
Q

Spinothalamic Tract (Pain-temperature, some light touch)

A

Crosses over to other side of spinal cord almost immediately and then ascends to thalamus and cerebral cortex on that opposite side

a lesion in the spinothalamic tract will result in loss of pain-temperature sensation contralaterally, below the level of the lesion

77
Q

Posterior Columns (conscious Proprioception—stereognosis, vibration, and some light touch)

A

2 columns:
! fasciculus gracilis
! fasciculus cuneatus
• Initially remains on same side of spinal cord
• Crosses over at junction of spinal cord and brain stem

78
Q

o Spinocerebellar (unconscious proprioception)

A

Does not cross spinal cord

• Ipsilateral sxs

79
Q

Descending Tracts (Motor)

A

Corticospinal Pathway
• Extends from motor area of cerebral cortex down through the brain stem, crossing over at medial lemniscus (junction between brain and spinal cord

80
Q

Upper Motor Neuron (UMN):

A

pathway from brain to spinal cord before synapse

81
Q

Lower Motor Neuron (LMN)

A

postsynaptic pathway from spinal cord to periphery (peripheral nerve)