Neuro Flashcards

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1
Q

What do unequal pupils indicate in head injury?

A

HIGH ICP (due to compression of ipsilat CN 3> inactivates PNS > pupil dilatation, loss of light reflex)

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2
Q

What are indications for immediate CT head following head injury?

A
  • GCS <13 immediately, <15 after 2 hours
  • Fracture (suspected open/depressed skull fracture of basal skull fracture)
  • Seizure
  • focal neurological deficit
  • vomit >1
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3
Q

What are signs of a basal skull fracture

A

Haemotympanum
Panda eyes
CSF leak (otorrhoea or rhinorrhoea)
Battle sign (mastoid bleed)

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4
Q

What are indications for immediate CT spine

A
  • GCS <13
  • Patient intubated
  • Clinical suspicion AND >65/high impact / focal neuro deficit / paraesthesia
  • a definitive diagnosis of a cervical spine injury is urgently needed (for example, if cervical spine manipulation is needed during surgery or anaesthesia)
  • blunt polytrauma involving the head and chest, abdomen or pelvis in someone who is alert and stable
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5
Q

What are indications for CT head soon <8h from injury

(Less strict than 1hr criteria)

A

For people 16 and over who have had some loss of consciousness or amnesia since the injury, do a CT head scan within 8 hours of the head injury, or within the hour in someone presenting more than 8 hours after the injury, if they have any of these risk factors:

  • age 65 or over
  • any current bleeding or clotting disorders
  • dangerous mechanism of injury
  • more than 30 minutes’ retrograde amnesia of events immediately before the head injury.
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6
Q

What are signs and sx of raised ICP

A

headache / vomiting
altered GCS, focal neuro deficit
Cushing’s response (high BP, low HR, cheyne-stokes respiration)

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7
Q

What are holding measures for a pt with raised ICP

A
  • sit up 40 degrees
  • if intubated: hyperventilate them (high ventilation causes hypocapnia >vasoconstriction of cerebral arteries > reduces cerebral blood flow and volume)
  • Osmotic agents eg mannitol
  • consider steroids if oedema surrounding tumour
  • fluid restrict
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8
Q

What is Cauda Equine Syndrome

A

Symptoms caused by compression of the cauda equine (below L2)

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9
Q

What are red flag symptoms of cauda equine

A

Bilateraal sciatica
Saddle anaesthesia
Lower limb weakness (+ reduced sexual function)

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10
Q

What are white flag sx of cauda equina (too late!)

A
Urinary retention (complete lack of sensation of fullness)
Urinary/faecal incontinence
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11
Q

What aree investigations for CES

A

clin exam (LL neuro, saddle anaesthesia, DRE)
Bladder scan
MRI

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12
Q

What is management for CES

A

PO dexamethasone (if metastatic, while awaiting MRI results)

Decompressive laminectomy (if <48hours from bladder dysfunction

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13
Q

most common causes of SC compression

A

metastases (oncological emergency)

lung, breast, prostate cancer

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14
Q

sx SC scompression

A

back pain (worse on coughing, lying down)

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15
Q

when is SC compression UMN /LMN

A

Above L1: UMN

Below L1: LMN

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16
Q

Ix for SC compression

A

MRI spine. urgent

FBC, CRP, UE, calcium
Urine for Bence Jones (MM)

17
Q

Mx SC compression

A

Dexamethasone +-radiotherapy, surgery

18
Q

what should ICP normally be

A

ICP <15mmHg

19
Q

what is status epilepticus

A

Seizure lasting >30 mins

20
Q

What can early status epilepticus be classified as, and how would you treat it

A

Early: 5-30mins&raquo_space;> Lorazepam
EEstablished: 30-60mins&raquo_space; phenytoin
Refractory: >60mins&raquo_space; anaesthetics

21
Q

What ix do you get in status epilepticus

A

Cap glucose
lab glucose, U&E, Ca, FBC, ECG, LFT
ABG
Put on cardiac monitor and pulse oxymetry
Consider tox screen, anticonvulsant levels, LP, culture blood and urine, EEG, head CT.

22
Q

How do you manage Status epilepticus

A

A>E
(secure airway, adjuncts as necessary, remove false teeth if poorly fitting)

O2 + suction

IV bolus lorazepam 4mg (10mg buccal midaz / 10mg PR diazepam if no IV access)

Give second dose Lorazepam if no improvement after 10-20mins

Consider thiamine if alcoholic, glucose if abnormal, tx acidosis, call up ITU

Start PHENYTOIN INFUSION

If seizure continues after 60 mins >General anaesthetic

23
Q

symptoms of meningitis

A
  • Severe headache
  • Nausea and vomiting
  • Photophobia
  • Neck stiffness or backache
  • Irritability
  • Drowsiness
  • High-pitched crying or fits (common in children)
  • Reduced consciousness
  • Fever
24
Q

What is Kernig’s sign

A

with hips flexed, there is pain/resistance on passive KKKKKKnee extension

25
Q

What is Brudzinski’s Sign

A

Flexed neck causes involuntary flexion of the hips

Sign of meningitis

26
Q

What Ix should you get for suspected meningitis

A

Blood cultures
Bloods - glucose (may be deranged in bacterial men), U&E, FBC, VBG (for lactate), LFTs, coag (exclude DIC), CRP, HIV
CT before LP if suspecting raised ICP
LP + MS&S of aspirate - but if LP cannot be completed within 1 hour, start Abx

27
Q

What is contained in a coagulation screen

A

PT, APTT, INR, fibrinogen, fibrin degradation products

28
Q

What Abx do you give first line in community

A

community: IM benzylpenicillin 1.2 g

29
Q

What must you give along with Abx in meningitis

A

IV dexamethasonne

30
Q

Brown Sequard syndrome

A

hemisection of spinal cord

  • ipsilateral hemiparaplegia
  • contralateral hemianaestthesia