Neuraxial Anesthesia Flashcards
General Facts about neuraxial anesthesia vs. GA
Neuraxial anesthesia can be an alternative to general anesthesia
Neuraxial anesthesia may be used simultaneously with general anesthesia or afterward for postoperative analgesia
Neuraxial blocks can be performed as a ____ or ___.
single injection or with a catheter to allow intermittent boluses or continuous infusions
Neuraxial blocks may reduce the incidence of ____.
- venous thrombosis and pulmonary embolism
- cardiac complications in high-risk patients
- bleeding and transfusion requirements
- vascular graft occlusion
- pneumonia
Postoperative epidural analgesia may also significantly reduce both the need for _____.
mechanical ventilation and the time until extubation after major abdominal or thoracic surgery.
Cesarean delivery is most commonly performed under ___.
spinal or epidural anesthesia
Regional anesthesia for cesarean delivery is associated with less maternal morbidity and mortality than general anesthesia d/t aspiration and failed intubation
The primary site of action for neuraxial blockade is ____.
the nerve root
Mechanism of action of spinal anesthesia
a relatively small volume of medication is injected into the subarachnoid space, mixes with cerebral spinal fluid, and provides a dense sensory and motor blockade
Mechanism of action of epidural and caudal anesthesia
a relatively large volume of medication is injected into the epidural space, and provides a differentiated blockade to the middle of the nerve roots
Differential blockade typically results in ____.
sympathetic blockade (judged by temperature sensitivity) that may be two segments or more cephalad than the sensory block (pain, light touch), which, in turn, is usually several segments more cephalad than the motor blockade.
Blockade of the posterior nerve root fibers interrupts ____.
somatic and visceral sensation
The physiological responses to neuraxial blockade result from _____.
decreased sympathetic tone or unopposed parasympathetic tone, or both
List the divisions of the nervous system
1) Central and peripheral nervous systems
2) The peripheral nervous system is divided into the somatic and autonomic nervous systems
3) The autonomic nervous system is divided into the sympathetic and parasympathetic nervous systems
The sympathetic outflow is also called the ____.
thoracolumbar outflow
The sympathetic, or thoracolumbar, outflow arises from segments ___.
T1–L2 or segments T1–L3
Most sympathetic preganglionic neurons synapse with ___.
postganglionic fibers in the paravertebral ganglia
Sympathetic cardiac accelerator fibers arise from ____.
T1–T4
The stellate ganglion is formed by the ____.
inferior cervical and first thoracic ganglia
*stellate ganglion is important as it relates to horners syndrome
A massive sympathetic response would lead to ___.
tachycardia, dry mouth, bronchodilation and diaphoresis.
Effects of sympathetic nervous system on body organs
Eye - The pupil dilation (mydriasis)
Heart - Increased heart rate
Secretions - Decreased salivary and bronchial secretions
Smooth Muscle - Bronchodilation, and decreased motility and tone of the stomach and intestines and relaxation of the bladder (detrusor muscle)
Pancreas – Increased blood glucose
The sympathetic NS is ____ compared to the peripheral NS?
The sympathetic nervous system is anatomically and functionally more systemic in its effects when compared to the PNS
Which nervous system is associated with the fight or flight response?
sympathetic
The parasympathetic outflow is also called the ___.
craniosacral outflow
The parasympathetic, or craniosacral, outflow arises from cranial nerves _____.
III, VII, IX, and X and sacral segments S2, S3, and S4
(3, 7, 9, 10)
Cranial nerve III arises from the ___.
midbrain
Cranial nerve VII arises in the ___
pons
Cranial nerves IX and X arise from the ____.
medulla
The parasympathetic nervous system is ___ compared to the SNS.
anatomically and functionally more selective and localized in its effects
The parasympathetic nervous system functions primarily to _____.
conserve energy and maintain organ function (resting and digest)
A massive parasympathetic response would lead to ____.
salivation, wheezing, weeping, vomiting, urinating, defecating, and seizing.
Effects of the parasympathetic NS on the body organs
Eye - The pupil constricts (miosis)
Heart - Decreased heart rate
Secretions - Increased salivary and bronchial secretions
Smooth Muscle - Bronchoconstriction, gall bladder contraction, increased motility and tone of the stomach and intestines and contraction of the bladder (detrusor muscle)
Neuraxial anesthesia will likely result in varying degrees of ____.
hypotension and bradycardia
How does hypotension occur with neuraxial anesthesia?
Vasomotor tone is primarily determined by sympathetic fibers arising from T5 to L1, innervating arterial and venous smooth muscle.
Vasodilation of veins decreases preload and often decreases cardiac output
Arterial vasodilation decreases compensatory vasoconstriction
In general, a more cephalad (towaards the head) blockade results in increased hemodynamic instability
How does bradycardia occur with neuraxial anesthesia?
A high sympathetic block may also block the sympathetic cardiac accelerator fibers that arise at T1 to T4
Unopposed vagal tone may explain the sudden cardiac arrest sometimes seen with spinal anesthesia
Treatment of hypotension and bradycardia related to neuraxial anesthesia
Pharmacologic interventions
- A bolus of intravenous fluid (5–10 mL/kg) in patients with appropriate cardiac and renal function
- Ephedrine is the first line therapy; glycopyrrolate or atropine can be used for symptomatic bradycardia
Positioning interventions
- Autotransfusion by placing the patient in the head-down position
- Left uterine displacement in the third trimester of pregnancy helps to minimize physical obstruction to venous return
the diaphragm is innervated by the ____.
phrenic nerve (C 3, 4, 5)
Pulmonary effects of neuraxial anesthesia
Overall, pulmonary function is not impacted by neuraxial anesthesia
However, patients with severe chronic lung disease may rely on the intercostal and abdominal muscles to actively inspire or exhale, therefore high levels of neural blockade will impair these muscles
Postoperative thoracic epidural analgesia in high-risk patients can ___.
improve pulmonary outcome by decreasing the incidence of pneumonia and respiratory failure, improving oxygenation, and decreasing the duration of mechanical ventilatory support
Gastrointestinal effects of neuraxial anesthesia
Unopposed vagal stimulation results in a small contracted gut and increase peristalsis, which can be helpful during intestinal surgery
Postoperative epidural analgesia decreases systemic opioid requirements, which can expedite the return of GI functioning
Hepatic blood flow is decreased from neuraxial and general anesthesia
GU Effects of Neuraxial Anesthesia
Renal blood flow is maintained by autoregulation
Bladder function is controlled by the sympathetic and parasympathetic nervous system, therefor patients are at risk for urinary retention
Patients without urinary catheters should receive judicious amounts of intravenous fluids, short acting medications neuraxially and assessed for bladder distention
Metabolic and Endocrine Effects of Neuraxial Anesthesia
Neuraxial blockade can partially suppress (during major invasive abdominal or thoracic surgery) or totally block (during lower extremity surgery) the neuroendocrine stress response
To maximize this blunting of the neuroendocrine stress response, neuraxial block should precede incision and continue postoperatively
Neuraxial blocks may be used ____.
alone or in conjunction with general anesthesia for many procedures below the neck.
As a primary anesthetic, neuraxial blocks have proved most useful in ____.
lower abdominal, inguinal, urogenital, rectal, and lower extremity surgery.
Which type of neuraxial anesthesia would you use for a breast surgery?
Need for GA?
Epidural
Yes, needs GA
Which type of neuraxial anesthesia would you use for a thoracic surgery?
Need for GA?
Epidural
Yes, needs GA
Which type of neuraxial anesthesia would you use for a major abdominal surgery?
Need for GA?
Epidural
Yes, needs GA
Which type of neuraxial anesthesia would you use for a hip replacement surgery?
Need for GA?
Spinal or epidural
No, you do not need GA
Which type of neuraxial anesthesia would you use for a knee replacement surgery?
Need for GA?
Spinal
No, you do not need GA
What are the abdolute contraindications to neuraxial anesthesia?
Infection at the injection site
Lack of consent
Coagulopathy
Severe hypovolemia
Increased ICP
What are the relative contraindications to neuraxial anesthesia?
- Sepsis
- Uncooperative patient
- Preexisting neurological deficits
- Stenotic heart valves
- LV outflow obstruction
- Severe spinal deformity
When bleeding occurs in the closed space of the spinal canal, the expanding hematoma can cause ___.
pressure on the spinal cord or cauda equina, which in turn may lead to spinal cord ischemia and infarction, with potential for severe neurologic injury or paraplegia
The decision to use neuraxial anesthesia in patients who either have been or will be receiving antithrombotic medication must ___.
weigh the benefit of the neuraxial anesthetic against the risk of spinal epidural hematoma
For patients on Warfarin, what are the requirements to place an epidural catheter/remove one?
Must be 4 to 5 days from their last dose and verify normal INR
For patients on IV Heparin, what are the requirements to place an epidural catheter/remove one?
After placement/removal, when can you restart the drip?
Must be 4 to 6 hours after holding gtt and verify normal aPTT
Can restart gtt one hour after
For patients on subcutaneous low dose thromboprophylaxis Heparin, what are the requirements to place an epidural catheter/remove one?
must be placed 4 to 6 hours after last dose or verify normal aPTT