Neural Crest and Eye Development - 19

Question 1

Neural crest cells originate from ___

Answer 1

the lateral margins of the neural plate

*Neural crest cells are initially epithelial in nature and then transform into mesenchymal cells for migratory purposes.

Question 2

Induction of neural crest tissue from non-neural ectoderm:

Answer 2

• BMPs and Wnts

* Use text to explain role of concentration differences and inhibitory action of noggin and chordin.

Question 3

Induction of neural crest tissue from mesoderm:

Answer 3

FGF-8

Question 4

While in the neural tube, neural crest cells are ___. __ and __ are important in forming tight-junctions

Answer 4

epithelial

cadherins and other CAMS

Question 5

Factors involved in breaking free

Answer 5

• CAMs are lost and remain down-regulated during migration but may be re-expressed at end of migration.
• Snail-1, Snail-2, and Foxd3 are important in allowing cells to break free.

Question 6

Migratory Pathways of NC cells

Answer 6

1) Ventral/sympathoadrenal path
2) ventrolateral path
3) dorsolateral path