Nervous system D/o-PPt -Josh

Question 1

Parkinson’s Disease:

PD is known as a neuro______ diseaae

Answer 1

NeuroDEGENERATIVE

Question 2

Parkinson’s Disease:

what is the #1 risk factor?

Answer 2

Increasing Age

Question 3

Parkinson’s Disease:

is a deficiency of dopaminergic innervation of the Basal Ganglia, from the _____ ______

Answer 3

Substantia Nigra

Question 4

Parkinson’s Disease:

Degeneration of the ___________ pathway leads to depletion of the neurotransmitter dopamine

Answer 4

Nigrastriatal

Question 5

Parkinson’s Disease:

S/S

Answer 5

• Skeletal Muscle tremor
• Rigidity
• Akinesia
• Bradykinesia
• Postural Instability

Question 6

Parkinson’s Disease:

what are the 2 types of regidity?

Answer 6

1. Plastic rigidity- constant through ROM; lead pipe PROM
2. Cogwheel rigidity- breif palpable jerks

Question 7

Parkinson’s Disease:

what is Akinesia

Answer 7

• An absence or lack of control of voluntary muscle groups

Question 8

Parkinson’s Disease:

what is bradykinesia

Answer 8

Slowness of voluntary movement

Question 9

Parkinson’s Disease: Anesthesia

do these pt’s continue Levodopa preop

Answer 9

yepper

Question 10

Parkinson’s Disease: Anesthesia

what are 3 pharmacological treatment options

Answer 10

• Levodopa
• Synthetic Dopamine Agonist
• Anticholinergic

Question 11

Parkinson’s Disease: Anesthesia

what are 3 drugs to avoid giving to these pt’s?

Answer 11

Droperidol

Haloperidol

Alfentanil

Question 12

what is a chronic and progressive autoimmune d/o involving the demyelination of axons?

Answer 12

MS

Question 13

Multpile Sclerosis:

MS is specific to what part of the nervous system

Answer 13

CNS

Question 14

Multpile Sclerosis:

the irreversible damage is called by what 5 thinks

Answer 14

• Inflammation
• Oligodendrocyte injury
• Demyelination
• Axonal Degeneration
• Formation of Plaques

Question 15

Multpile Sclerosis:

Symptoms/ how does it appear for example constant ot remissions

Answer 15

• exacerbations
• Relapses
• Remissions
• eventually Symptoms persist during remissions, leading to severe disability

Question 16

Multpile Sclerosis:

whare does demylination occur (3), and what is the manifestation?

Answer 16

• Optic Nerve- Visual failure
• Cerebellum Involvement- Gait disturbances
• Spinal Cord Lesions- Skeletal muscle weakness/ urinary incontinenc/ Ataxia

Question 17

Multpile Sclerosis: Anesthesia

Surgical stress can exacerbate the symptoms- and a temp change of __C can exacerbate symptoms

Answer 17

1

Question 18

Multpile Sclerosis: Anesthesia

what MR do you want to avoid? why?

Answer 18

DMB (SCh)- d/t hyperkalemia

Question 19

Huntington’s Disease:

is a heredity degenerative d/o that is ________ dominant

Answer 19

Autosomal Dominant

Question 20

Huntington’s Disease:

effects what 2 parts of the brain?

Answer 20

• basal Ganglia
• Cerebral Cortex

Question 21

Huntington’s Disease:

it is also know as what name?

Answer 21

Chorea

Question 22

Huntington’s Disease:

the basal ganglia is depleted of what NT

Answer 22

GABA

Question 23

Huntington’s Disease:

S/S

Answer 23

Abnormal movement

Dementia

restlessness

irritabilty

Question 24

Huntington’s Disease: Anesthesia

the is an increased sensitivy to which MR ND or Dep?

Answer 24

Both

Question 25

Huntington's Disease: Anesthesia what 2 meds are great for pre-treatment

Answer 25

* Droperidol * Halperidol

Question 26

What is the functional Abnormality associated w/ at least 1 never root?

Answer 26

* radiculopathy

Question 27

Radiculopathy: may be caused by what 3 things?

Answer 27

1. compression 2. Inflammation 3. Acute trauma

Question 28

Huntington's Disease: Anesthesia Muscles innervated by involved nerve root may display what S/S

Answer 28

* Atrophy * Weakness * decreased DTRs * sensry alterations

Question 29

what are the 3 types of neuropathies ## Footnote

Answer 29

Generalized focal or multifocal Generalized symmetric

Question 30

what type of Nueropathy affect the cell body of only ONE peripheral nerve?

Answer 30

Generalized

Question 31

Generalized Nueropathy: what are the 2 types

Answer 31

1. Motor 2. Sensory

Question 32

Generalized Nueropathy: ALS is an example of what type of Generalized Nueropathy:

Answer 32

Motor

Question 33

Generalized Nueropathy: Leprosy and Industrial poisoning is an example of what type of Generalized Nueropathy:

Answer 33

Sensory

Question 34

What type of Neuropathy affect sensory or motor in one or more nerves?

Answer 34

Focal or Multifocal Neuropathies

Question 35

Focal or Multifocal Neuopathies: what is an example of this?

Answer 35

Carpal tunnel syndrome

Question 36

what type of Neuropathy is SYMMETRIC involement of sensory, motor, or autonomic fibers?

Answer 36

Generalized Symmetric Polyneuopathies:

Question 37

Generalized Symmetric Polyneuopathies: what are the 3 types

Answer 37

1. Distal Axonal Polyneuopathies 2. Demyelinated Polyneuopathies 3. Axonal Degeneration

Question 38

Generalized Symmetric Polyneuopathies: which one of the 3 is the most common?

Answer 38

Distal Axonal Polyneuopathies:

Question 39

Generalized Symmetric Polyneuopathies: what is an example of Distal Axonal Polyneuopathies: (hint think distal AKA legs)

Answer 39

DM ETOH abuse

Question 40

Generalized Symmetric Polyneuopathies: which one is the least common

Answer 40

Demylinating

Question 41

## Footnote Generalized Symmetric Polyneuopathies: what is an exaample of the demyelinating

Answer 41

Guillian- barre

Question 42

Generalized Symmetric Polyneuopathies: how is axonal degeneration done

Answer 42

disatl dgeneration of axon fist followed by degeneration of myelin

Question 43

Myelopathy: 2 types

Answer 43

1. HIV Myelopathy: 2. Vascular Myelopathy:

Question 44

Myelopathy: which one is DIFFUSE degeneration of the spinal cord

Answer 44

HIV Myelopathy:

Question 45

## Footnote Myelopathy: then I guess... which one is Lateral and posterior spinal colums of the lumbar spinal cord! And progressive spastic paraparesis w/ ataxia

Answer 45

vascular Myelopathy:

Question 46

Thats it

Answer 46

your done