Nervous System Flashcards
Functions of Myelin Sheath
insulation, protection and impulse speed increaser
Neurilemma
layer that helps in the repair of injured nerve fibres, wrapped around the Schwann cells
Neuromuscular Junction
‘synapse’ between an axon and a skeletal muscle cell.
Functional Neuron types
Sensory - carry nerve impulses from receptors in sense organs or skin into CNS
Motor - carry nerve impulses from CNS to effectors (muscles and glands)
Interneuron - carry nerve impulses between sensory and motor neurons
Structural Neuron types
Multipolar - 1 axon, multiple dendrites, includes most interneurons and motor neurons
Bipolar - 1 axon, 1 dendrite (both may have branches at ends), occur in eye, ear and nose taking impulses from receptors to other neurons
Unipolar - 1 axon (not found in humans)
Pseudounipolar - 1 axon that splits into two extensions (one end with dendrites and the other with dendrites), includes most sensory neurons
Neuron
nerve cell
Nerve fibre
any long extension of cytoplasm of a nerve cell body - though it usually refers to the axon
Nerve
bundle of nerve fibres held together by connective tissue. called tracts within the CNS, nerves outside it
Extracellular fluid contains?
high concentration of sodium ions (10x higher outside than in). sodium diffusion = limited due to low number of sodium leakage channels
Intracellular fluid contains?
low concentration of sodium ions, but contains potassium ions (30x higher inside than out). potassium diffusion = easy due to high number of potassium leakage channels
Resting Membrane Potential value
around -70mV (i.e. potential inside is 70mv less than outside; it is polarised)
RMP cause
differences in the distribution of sodium and potassium ions (extracellular fluid = more positive than intracellular)
Sodium-potassium pump
carrier protein which moves 2 potassium ions in for every 3 sodium ions removed, i.e. causing a net reduction of positive ions into the cell. against concentration gradient, therefore is active transport and requires ATP
Action potential definition
rapid depolarisation and repolarisation of the membrane caused by opening and closing of voltage-gated channels
Depolarisation (AP)
sudden increase in membrane potential if level of stimulation exceeds 15mV. some sodium channels are opened (ligand- or mechanical-gated) and sodium ions move into cell. if stimulus is strong enough to increase MP to -55mV, voltage-gated sodium channels open, allowing for independent movement of sodium ions into the cell (all or none response). MP reaches +40mV.
Repolarisation (AP)
soon after depolarisation, sodium channels close and voltage-gated potassium channels open, increasing flow of them out of cell. MP decreases again back to -70mV.
Hyperpolarisation (AP)
after repolarisation, potassium channels remain open for longer than is needed; MP decreases further than RMP.
Refractory Period
once sodium channels are opened, they are quickly inactivated (i.e. unresponsive to stimulus)
Transmission of Nerve Impulse
depolarisation of one area causes movement of sodium ions into adjacent areas. this stimulates the opening of voltage gated sodium channels in next part of membrane, initiating a new action potential in said part.
Saltatory Conduction
Because ions cannot diffuse in myelinated areas, they simply jump from one node of Ranvier to the next. this allows myelinated fibres to carry nerve impulses faster than unmyelinated ones