Nervous System Flashcards
Acetylcholinesterase inhibitors used in Alzheimer’s
Donepezil
Galantamine
Rivastigmine
NMDA Receptor Antagonist used in Alzheimer’s
Memantine
What class is Rivastigmine and when to stop?
Acetylchloinesterase Inhibitor
Stop if serious skin reaction
Which drugs need same brand in epilepsy
Carbamazepine
Phenytoin
Phenobarbital
Primidone
CP3
Symptoms of anti-epileptic hypersensitivity syndrome
Fever
Rash
Lymphadenopathy
Liver dysfunction
Renal
Haematological
Patient should not be rexposed!
What to do in anti-epileptic withdrawal?
Avoid abrupt withdrawal
Risk of rebound seizure (even if seizure free for years)
Withdraw one drug at a time if multiple
Driving and seizures - what to do?
Report to DVLA
First unprovoked seizure- can’t drive for 6 months
Can patients with epilepsy drive?
Yes they can drive a motor vehicle
Not a large goods or person carrying vehicle
BUT they must have been seizure free for 1 year and established a 3 year period of asleep attacks without awake attacks
Heavy goods vehicle - 5 years
Which drugs lower the seizure threshold?
SSRI’s
TCA’s
Antipsychotic
Carbapenems
Tramadol
Quinolones
Methadone
Which epileptic drugs are OK in pregnancy
Oxcarbamazepine
Levetiracetam
Ethosuximide
What supplement can be given if patient is on anti epileptic and wants to fall pregnant?
Folate before and during the first trimester
- reduces the risk of neural tube defect
What effect can topiramate have on a growing foetus?
Cleft palette
What is the treatment for absence seizures?
SEAL
Sodium Valproate
Ethosuximide
Lamotrigine
What is the treatment for MYOCLONIC seizures
SALT
Sodium Valproate
Levetiracetam
Topiramate
What is the treatment for ATONIC and TONIC seizures and TONIC-CLONIC seizures?
SLACO
Sodium Valproate
Lamotrigine
Carbamazepine
Oxcarbazepine
