Nerve Trauma and Tumors

Question 1

What is a traumatic neuroma?

Answer 1

Regenerating axons growing haphazardly into scar tissue; Swelling is painful;

Question 2

What is a Morton Neuroma? Cause?

Answer 2

Painful, sausage-shaped swelling of plantar interdigital nerve betwixt second and third or third and fourth metatarsal bones; Probably due to compression

Question 3

What are the two common nerve sheath tumors?

Answer 3

Schwannoma and Neurofibroma

Question 4

A patient presents with a long history of progressive hearing loss in his left ear. What type of benign neoplasm is likely causing these Syx?

Answer 4

Vestibular Schwannoma

Question 5

A schwannoma is shown below. What are the two types of morphology shown?

Answer 5

Top - Antoni A pattern - compact

Bottom - Antoni B pattern - Loose and vacuolated

Question 6

What are the neoplastic cells in neurofibromas?

Answer 6

Schwann cells

Question 7

What disease are neurofibromas associate with?

Answer 7

Neurofibromatosis Type 1

Question 8

Are most neurofibromas occur in the context of NF1?

Answer 8

Nope!

Question 9

Describe the integration between a neurofibroma and a nerve and compare it to a schwannoma

Answer 9

Nerve fibers course througha neurofibroma whereas in a schwannoma, nerve fibers are pushed to the side

Question 10

What is the malignant tumor associated with peripheral nerves?

Answer 10

Malignant peripheral nerve sheath tumor (MPNST)