Nerve blocks Flashcards
(10 cards)
Esters vs amides based on name
Amino esters - one i in name
Amino Amides - 2 is in name
Esters vs amides
Onset
duration
allergy risk
Local anaesthetic systemic toxicity risk
metabolism
volume of distribution
pKa
Which types of nerves are blocked most readily by local anaesthetic?
Why use cold block / ice (or movement) to test nerve block
Temp fibres blocked after pain -> can be more sure of block
Options to prolong a nerve block
Adrenaline - vasoconstrics -> less blood flow -> slows distribution / absorption
Clonidine - enhances effects
Dexmed
Dexamethasone
Which locations of local anaesthetic have the highest systemic absorption / lowest
What is LAST in local anaesthetic
Local anaesthetic systemic toxicity
Importantly cardiac electrophysiological and contractile dysfunction
Key drug for circulatory collapse with LAST
Intralipid 20% 1.5mg/kg in 1 min
followed by 15mg/kg over 1 hour
How does intralipid work
Increases LA clearance from cardiac tissue
Common genetic issue which means LA doesnt work properly
Ehlers danlos syndrome
