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KIdneys > Nephrotic syndrome > Flashcards

Nephrotic syndrome Flashcards

1
Q

Nephrotic syndrome basic principles

A

loss of protein in urine (proteinuria ) loss greater than 3.6g/day
resulting in
1- hypoabunemia
2-hypogammaglobunemia -increased risk of infections
3-hypercoagulable state due to loss of antithrombin 3
4- hyperlipedemia and hypercholestrolemia

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2
Q

minimal change disease most common in ?

A

children

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3
Q

MCD -minimal change disease associated with

A

hodgkins lymphoma

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4
Q

MCD -minimal change disease principle

A

no immuno diposits/ selective proteinuria -only albumin loss/excellent response to steroids /

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5
Q

focal segmental glomeruloscelrosis (FSFG) common in

A

hispanics and african americans

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6
Q

focal segmental glomeruloscelrosis (FSFG) etiology

A

sickle cell
HIV
heroin use

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7
Q

focal segmental glomeruloscelrosis (FSFG) principles

A

focal and segmental membrane deposits
effacement of foot processes on EM
no immune complexes
poor response to steroids –progresses to chronic renal failure

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8
Q

Membranous nephrotpathy

A

thick glomerular basement membrane
immune complex deposits
spike and dome appearance
poor response to steroids -progresses to chronic renal failure

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9
Q

which respond poorly to steroid and progress to chronic renal failure

A

membranous nephropathy and
FSFG
membranoproliferative glomerulonephritis

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10
Q

membranous nephropathy etiology

A 
hep b 
hep c
SLE
tumor that are solid
drugs like NSAIDS and penicillamine
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11
Q

membranous nephropathy common among ?

A

caucasian adults

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12
Q

membranous nephropathy can progress to ?

A

chronic renal failure

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13
Q

membranoproliferative glomeruloneptritis morphology

A

thick basement membrane on h and e

tram track appearance due to immune complex deposition

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14
Q

membranoproliferative glomeruloneptritis principles

A

divided in two
type 1 associated with sunendothelial
type 2 associated with dense deposit disease

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15
Q

type 1 membranoproliferative glomeruloneptritis

A

subendothelial associated with HBV/HCV

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16
Q

Type 2 membranoproliferative glomeruloneptritis

A

associated with C3nepritic syndrome which makes C3 convertase stable leading to overactivation of inflammation and low levels of c3

17
Q

diabetes melitus

A

leads to glycosylation of basement membranes resulting in hyaline arteriosclerosis
efferent more affected that affernt leading to high GFR
eventually progresses to neprotic syndrome -kimmerstein wilson nodules
ACE inhbitors can slow the progress

18
Q

kimmelstein wilson nodules associated with

A

diabetes millitus causing neprotic syndrome

KIdneys (1 decks)

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