Nephropathology

Question 1

histo patterns w/ hypercellularity

Answer 1

in glomerulus: proliferative (lots of extra nuclei)

in bowmans capsule: crescentic

Question 2

histo pattern w/ increased cap wall thickness

Answer 2

membranous

Question 3

5 possiblities of focal collections in glomerulus

Answer 3

1. increased mesangium
2. necrosis
3. thrombosis
4. amyloid
5. sclerosis

Question 4

describe pathogenesis of crescent formation

Answer 4

• glomerulus is inflamed
• focal capillary destruction
• exudation into bowmans space (fibrin, macros, mediators)
• parietal epithelial proliferation forms crescent

Question 5

4 types of immune pathogenesis w/ nephropathology

Answer 5

• immune complex
• IgA
• anti GBM
• ANCA

Question 6

3 possible pathways of immune complex pathogenesis

Answer 6

• first, formation or deposition of Ag-Ab complexes (can cause membranous patho, depends on where the deposition occurs- ie subendothelial or subepithelial)
• could have complement activation and thus low blood complement (used up)
• could have PMN chemotaxis (proliferative)
• could have mesangial proliferation (mesagioproliferative pattern)

Question 7

renal types of vascular disease that cause renal patho

Answer 7

small vessel vasculitides