Nephrology Flashcards

1
Q

What is the pH for measuring acidemia or alkalemia

A

7.4

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2
Q

What is the CO2 content of the body?

A

40

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3
Q

Anion gap formula? Normal?

A

Na-Cl-bicarb; 12 is normal

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4
Q

Why do you always calculate anion gap?

A

Always check it because if you have an increased anion gap acidosis then you always have anion gap acidosis nomatter what else is going on

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5
Q

What do you do after you identiy a respiratory acidosis?

A
  • 7.4 - (dimes x 0.08) = pH if acute
  • 7.4 - (dimes x 0.04) = pH if chronic
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6
Q

What do you do after you after you figure out if the acidosis is acute or chronic?

A
  • 24+ (dimes*1) = expected bicarb if acute
  • 24 + (dimes x 3) = expected bicarb if chronic
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7
Q

What do you do after determining that there is a respiratory alkalosis?

A

Dime changes in CO2 to determine chronicity

  • 7.4 - (dimes x 0.08) = pH if acute
  • 7.4 - (dimes x 0.04) = pH if chronic
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8
Q

What do you do after determining the chronicity of a respiratory alkalosis?

A

Dime changes in CO2

  • 24-(dimes x 2) = Expected bicarb if acute
  • 24-(dimes x 4) = expected bicarb if chronic
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9
Q

What do you do after checking the anion gap in metabolic acidosis?

A

Expected CO2 using winters formula

  • Expected CO2 = Winters = (Bicarb x 1.5) + 8 +/- 2
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10
Q

What do you do after doing winters formula in metabolic acidosis?

A

Add back method

  • Current anion gap - normal anion gap = x
  • X + current bicarbs = needed value
  • If this value is over 24 = metabolic alkalosis
  • If this value is under 24 then there is a metabolic acidosis
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11
Q

Causes of anion gap acidosis?

A

MUDPILES

  • Methanol
  • Uremia
  • DKA
  • Propylene
  • Iron
  • Lactic acidosis
  • Ethylene glycol
  • Salicylates
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12
Q

What are the causes of Non gap acidosis?

A

RTA or diarrhea depending on the urine anion gap

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13
Q

What is the normal urine chloride?

A

10

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14
Q

What is volume responsive metabolic alk?

A
  • Diuretics, dehydration, emesis, NG suction
  • Cl under 10 (because tubes can reabsorb Cl)
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15
Q

UCl > 10 and HTN is caused by

A

Inappropriate aldosterone

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16
Q

UCl >10 and no HTN is caused by

A

Genetic diseases

17
Q

Euvolemic hyponatremia causes

A

RATS

  • RTA
  • Addisons
  • Thyroid
  • SIADH
18
Q

Formula for serum osmoles

A

Serum osmoles = (2 x Na) + Glucose/18 + Bun/2.8

19
Q

EKG changes in hyperkalemia

A

“Everything gets bigger”

  • Peaked T waves
  • Prolonged QRS
  • PR interva lincrease
20
Q

Treatment of hyperkalemia

A

C BIG K DIE

  • C: Calcium - stabilize myocardium
  • B: Bicarb - Shifts K into cells
  • IG: Insulin and glucose - Shift K into cells
  • K: Kayexalate - Decreased K
  • D: Dialysis - Decreased K
21
Q

Hypokalemia causes

A

Renal losses

  • Hyperaldosterone
  • Loop diuretics
  • Thiazides

GI losses

  • Vomiting
  • Diarrhea
22
Q

What do you do if there is hypokalemia on labs? What do you do if confirmed?

A

Recheck K and check anEKG for findings

  • If confirmed replete at 10 mEq/hr by peripheral line and 20 mEq/hr by central line
23
Q

GFR ratings in kidney failure?

A
  • I: Over 90
  • II: 60-90
  • III: 30-60
  • IV: 15-30
  • V: Under 15
24
Q

A1C and glucose goals of people on insulin

A

A1C under 7 and bG 80-110

25
Q

Complications of renal failure and corresponding treatments

A
  • Anemia: EPO and iron with goal hemoglobin of 11-12
  • Scondary hypoparathyroidism: Phosphate binders like sevelamer and cincalcet
  • Volume overload: Loops and hemodialysis
  • Metabolic acidosis: Bicarb pills
26
Q

Acute renal failure presentation. What is the first thing you should notice?

A

Elevated creatinine or decreased urinary output

27
Q

Causes of prerenal acute kidney injury

A
  • Pump: CHF, MI
  • Fluid: Diarrhea, dehydration, diuresis, bleeding
  • Pipes: Nephrotic, cirrhosis, gastrosis
  • Clog: FMD, RAS
28
Q

Intrarenal causes of acute tubular necrosis

A
  • Prolonged ischemia
  • Toxins (drugs, myoglobin, Ig)
  • Contrast induced
29
Q

Intrarenal causes of acute interstitial nephritis

A
  • Allergic (NSAIDs and beta lactams)
  • Infection - pyelo
  • Infiltrative (sarcoid, amyloid)
30
Q

Glomerulonephritis causes

A
  • Glomerular disease
31
Q

Labs to check in acute renal failure? Treatment?

A
  • BUN:Cr Under 20
  • UNa < 10
  • FENa <1%
  • Tx: IVF or Diuresis
32
Q

How is postrenal kidney injury diagnosed? Treatment?

A
  • Ultrasound (Hydroureter and hydronephrosis)
  • Tx: Stent or remove obstruction
33
Q

If you suspect intrarenal acute kidney injury, what labs do you check?

A

Urinalysis, (look for casts) and do a biopsy if youre really really curious

34
Q

Indications for dialysis

A

AEIOU

  • Acidosis
  • Electrolyte imbalance
  • Ingestion of toxins
  • Overload (CHF, Edema)
  • Uremia (Pericarditis)
35
Q

Contrast induced ATN is prevented by what?

A

Hydration, prophylactic N acetyl cysteine, stopping ACEs, ARBs and duretics

36
Q

Phases of Acute Tubular Necrosis

A
  1. Prodrome: Creatinine rises but urine output remains the same
  2. Oliguric phase: Creatinine rises and urine output plummets
  3. Polyuric phase: Patient pees a lot
37
Q

Treatment of prerenal azotemia

A

IVF if dry, diuresis if wet

38
Q
A