Nephro/Uro Flashcards
- 4 year old child with nephrotic syndrome on steroids. Presents with a swollen and tender abdomen. Looks septic. What test would give you the diagnostic:
a. Paracentesis
b. CT scan
c. MRI
D. Laparotomy
Paracentesis
- Patient presents with edema, abdominal distension, and proteinuria. Patient also has fever and is found to have spontaneous bacterial peritonitis. What is the MOST likely pathogen causing the SBP.
a. Steptococcal pneumoniae
b. E. Coli
c. Enterococcus
d. Listeria
Strep pneumo
- 5 yo girl diagnosed with nephrotic syndrome and on high dose steroids. You’ve counselled that she shouldn’t receive any live vaccines. What should she get now?
a. HPV vaccine
b. HAV vaccine
c. Pneumococcal polysaccharide (23-valent) vaccine
d. Meningococcal conjugate vaccine
Pneumococcal polysaccharide 23-valent
Highest risk of strep pneumo
- Give 13-valent conjugate vaccine + 23-valent polysaccharide vaccine
- Annual influenza (+household)
- Defer live vaccines until prednisone <1mg/kg/d or <2mg/kg/d on alt days. Live vaccines contraindicated while on steroid sparing agents (cyclophosphamide, cyclosporine)
- If exposed to varicella, give VZV Ig. Avoid direct exposure to GI + resp secretions of vaccinated contacts for 2-6wks after vaccination with live varicella
- Child with 4+ proteinuria, distended abdo, fever. Most likely organism causing acute abdomen?
a. Ecoli
b. Strep pneumo
—————-
Child presents with facial edema, generalized edema and has proteinuria 4+, and concentrated urine 1.020. abdominal ascites. Physician performs peritoneal tap. What organism are you likely to find?
a. strep. Pneumoniae
b. e. coli
Strep pneumo
- Periorbital swelling with no tenderness, no fever and normal blood pressure. What do you do?
a. reassure
b. check for proteinuria
c. start antibiotics
Check for proteinuria
- Child with generalized edema, abdomen tender, 4+ protein in urine, hypoalbuminemic for 8 days.
a. Nephrotic syndrome with peritonitis
b. Appendicitis
Nephrotic syndrome with peritonitis
Urinary losses of IgG + complement
- 14 year old boy in office for pre-camp physical, 3+ protein in urine x2, exam is normal, what is most likely cause?
a. exercise induced
b. IgA nephropathy
c. nephritic syndrome
d. orthostatic
Orthostatic proteinuria
- 15 yo with 3+ proteinuria on routine exam.
a) Check Protein twice each am
b) 24 hr urine protein
c) renal function tests
Check protein twice each AM
- 12y old with diabetes Type I since the age of 5 with microalbuminuria despite optimum control of his diabetes. What should you start him on:
a. hydrochlorothiazide
b. nifidepine
c. enalapril
—————-
Diabetic with microalbuminuria. What would you prescribe?
a. Enalapril
b. Hydrochlorothiazide
c. Nifedipine
d. Salt and water restriction
Enalapril
- A child presents with hypertension, urine dip shows blood and protein, creatinine and urea are elevated, C3 and C4 are normal. What is the most likely diagnosis?
a. SLE
b. Membranoproliferative glomerulonephritis
c. Post-infectious glomerulonephritis
d. IgA nephropathy
IgA nephropathy
- What glomerular disease is associated with a low C3?
a. Membranous nephropathy
b. Alports
c. IgA nephropathy
d. Membranoproliferative glomerulonephritis
MPGN
- 7yo M with recent URTI who presents with respiratory distress and BP 150/110. Most likely diagnosis?
a. Pneumonia
b. Post strep GN
PSGN
- 4 year old girl with glomerulonephritis, hypertension, and vomiting x3 days. Most probable test to determine diagnosis (*question worded poorly)
a) C3
b) Renal Biopsy
C3
26.
Kid w PSGN, what to order?
a. Complements
Complement
- Patient with history of sore throat. Urine shows microscopic hematuria. What is the natural course?
a. It will resolve over time
b. Progress to chronic renal disease
c. microscopic hematuria
d. proteinuria and hypertension
It will resolve over time
C. Can have persistent microscopic hematuria for up to 1-2y, but eventually should resolve
B. <2% progress to chronic renal disease
D. Glomerulonephritis has HTN but minimal proteinuria
- Child with proteinuria (4+), hematuria, hypertension, low C3. (No mention of any viral symptoms nor URTI). What do you expect in 6 months?
a. Proteinuria, hematuria
b. Hypertension, proteinuria, hematuria
Persistent proteinuria + hematuria
(Sick Kids consensus)
Low C3 Primary 1. PSGN - microscopic hematuria up to 2y - HTN resolves by 4-6wks - C3 normalizes by 6-8wks - 10-20% can have nephrotic range proteinuria 2. MPGN - IgG + C3 deposition - nephrotic + microscopic hematuria - 20% have HTN at presentation
Secondary
- Vasculitis + AI (SLE neprhitis)
- Subacute bacterial endocarditis
- Shunt nephritis
- Cryoglobinemia
- Child with recent URTI. Now has periorbital edema and microscopic hematuria. What test to do that distinguishes between post-infectious GN and ___________ ?
a. C3
b. 24 hour protein
c. RBC casts
—————
PSGN vs. IgA - which test differentiates?
a. immunoglobulins
b. C3
c. 24-hour urine collection
d. ANA
C3
- Which of the following is a presentation of HUS?
a. Coombs + anemia
b. Thrombocytopenia
c. Myoglobinuria
**Thrombocytopenia
HUS
- MAHA
- microangiopathic => vessel injury that causes mechanical breakdown of RBCs-> anemia
- Coombs is usually negative except in pneumococci-assoc’d HUS - Uremia
- Thrombocytopenia
- normal coags
- A child with recent Group A strep infection, normal C3, C4, slightly increased creatinine, Platelets and low hemoglobin, with blood in the urine
a. HSP
b. HUS
c. Post strep GN
d. IgA nephropathy
—————–
Pt had GAS 2 weeks ago. Now presents with hemoglobin 70, Platelets of 30 and rising Cr and BUN. What is the diagnosis?
a. HUS
b. HSP
HUS
Normal C3C4 => not PSGN
Anemia
Renal insufficiency
Thrombocytopenia
Microscopic hematuria
- Recurrent hematuria in a young male with a speech delay
a. IgA nephropathy
b. Alport syndrome
c. PSGN
d. MPGN
Alport syndrome
- When should repair for a persistent hydrocele occur?
a. 6 months
b. 12 months
c. 18 months
d. 24 months
Refer at 12mo
Occur by 18mo
- Name 2 indications for surgery for a hydrocele.
- Persists beyond 12mo
- Communicating hydrocele
- Symptomatic hydrocele
- A 10 year old boy presents with 12 hours of scrotal pain. He has focal tenderness at the upper pole of the testis with a focal blue discolouration, and there is some edema. What is the best next step?
a. Ultrasound
b. Analgesia and scrotal support
C. Urology consult
——————— - Testicle w blue dot?
a. Reassure
———————
Analgesia, scrotal support, reassurance
Appendix testis torsion (occurs in 2-10yo, rare in adolescents)
- 13 y.o. presents with 3 day history of gradually worsening scrotal pain. On exam, you note tenderness at the superior pole of the right testis, with a bluish discolouration at the tip. Most appropriate next step in management:
a. testicular U/S with dopplers
b. testicular nuclear scan
c. urethral swab for chlamydia
d. supportive care and reassurance
————————
14 yo male presents with gradual onset of left testicular pain. Tenderness isolated to upper pole of testicle with bluish hue. What diagnostic test?
a. testicular nuclear scan
b. reassure and send him
c. testicular ultrasound
d. urethral chlamydial swab
Testicular U/S with dopplers
Though this is most likely torsion of the appendix testis given the isolation to the upper pole, it’s unusual in adolescents, so it would be worthwhile assess on testicular ultrasound rather than just reassuring
Uretheral chlamydial swab probably assessing for epididymitis
- 8 yo with description of torsion of appendix testis. Blue dot.
a. u/s with dopplers
b. analgesia and support testicle
c. stat surgical consult
Analgesia + support testicle
- A 14 year old boy presents with an acutely painful scrotum. You suspect testicular torsion. Which of the following is true?
a. absence of the cremasteric reflex is common
b. blue discoloration of the scrotum is pathognomonic
c. you have 36 hours to treat before losing the testes
Absence of the cremasteric reflex is common
B. Blue discoloration of the scrotum is suggestive of appendix testis torsion
C. <6H for 90% survival of testes