Nephritic Syndrome

Question 1

Characteristics of Nephritic Syndrome (5)

Answer 1

Low GFR (vasoconstriction from inflamm)
Urine Sediment (RBC, WBC, casts)
Proteinuria (sub nephrotic)
Edema (increased NA from low flow)
HTN (increased NA from low flow)`

Question 2

Primary Renal (6)

Answer 2

IgA Nephropathy
Anti-GBM
Membranoproliferative GN
Vasculitis (ANCA)
Hemolytic-Uremic Syndrome
C3 disease

Question 3

Systemic (6)

Answer 3

Henoch Schonlein
Goodpasture
Lupus Nephritis
ANCA vasculitis
Infection
Ig deposition

Question 4

Post Infectious GN

Answer 4

Group A Strep
ICs deposit and activate complement
Proliferative GN, inflammatory cells
IF: granular IgG, C3
Check ASO for Dx
Reversible damage

Question 5

IgA Nephropathy

Answer 5

Mesangial Proliferation w/ IgA deposits w/ C3
Crescents uncommon
ESRD possible
Treat w/ steroids

Question 6

MPGN

Answer 6

Mesangial proliferation and GBM thickening
Subendothelial/mesangial IgG deposits and C3
HCV associated
ESRD common

Question 7

Anti-GBM

Answer 7

RPGN +/- pulmonary
ABs to collagen IV of GBM
Extensive crescenting
Early treatment w/ steroids and immunosups w/ plasma exchange

Question 8

Pauci-Immune Renal Vasculitis

Answer 8

Small vessel vasculitis in kidneys w/o IC deposits
Crescenting
ANCA common
Lungs commonly involved
Treat: plasmapheresis, steroids, cyclophosphamide

Question 9

Lupus

Answer 9

Renal issues common w/ lupus

Granular C3, C1q, IgG/M/A deposits throughout

Question 10

Cryoglobulinemia

Answer 10

Common w/ HepC
IC deposits
Treat w/ anti-viral, rituximab (anti-B cell), and plasmapheresis

Question 11

Henoch-Schonlein

Answer 11

Palpable Purpura, arthritis, GN, and GI