Neoplasias Flashcards

1
Q

Describe CATBITES

A
  • Congenital
  • Arthritis
  • Trauma
  • Blood
  • Infection
  • Tumor
  • Endocrine/metabolic/nutritional
  • Soft tissue
    (Categorize various conditions from both imaging classes)
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2
Q

What components involve primary analysis?

A
  • Clinical (Age, Gender, Race, History)
  • Number/symmetry of lesions
  • Involvement of systems
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3
Q

What do you analyze when looking at lesions?

A
  • Location
  • Position within bone
  • Size
  • Shape
  • Margination
  • Matrix
  • Periosteal reaction
  • Soft tissues changes
  • Joint changes
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4
Q

What includes supplementary analysis?

A

Other imaging, lab diagnostics, biopsy

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5
Q

Non-aggressive (benign) lesions are usually ___

A

Asymptomatic (Can be symptomatic following a pathological fracture)

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6
Q

What can aggressive lesions cause?

A

Local pain or Palpable mass (Fever, altered ROM, cachexia and night-time bone pain)

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7
Q

What are the 5 major questions of lesion analysis?

A
  1. Which osseous structure is affected?
  2. Where is the lesion in that osseous structure?
  3. What is the pattern of destruction?
  4. What is the periosteum doing?
  5. What is the lesion matrix?
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8
Q

What are the behaviors of Osteolytic lesions?

A
  • Geographic
  • Motheaten
  • Permeative
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9
Q

What are the behaviors of Osteoblastic lesions?

A
  • Diffuse/multifocal
  • localized
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10
Q

Describe behavior of Osteolytic Geographic lesions

A
  • Narrow zone of transition
  • May have sclerotic/sharp border
  • Typically seen with non-aggressive
    lesions
  • Can be seen with internal
    septations leading to a soap-
    bubble appearance
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11
Q

Describe behavior of Osteolytic Motheaten lesions

A
  • Wide zone of transition
  • Ill-defined border
  • Multiple, tiny holes
  • Associated with aggressive conditions
  • Primary or secondary malignancy
  • infection
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12
Q

Describe behavior of Osteolytic Permeative lesions

A
  • Wide zone of transition
  • Ill-defined border
  • Pinhole-sized holes in the bone (may be too small to be seen)
  • Associated with aggressive conditions:
  • Primary or secondary malignancy
  • Infection
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13
Q

Describe behavior of Osteoblastic Diffuse/multifocal

A

Usually seen with metastatic disease

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14
Q

Describe behavior of Osteoblastic Localized lesion

A

Generally associated with non-aggressive lesions

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15
Q

What type of Tumor Matrix will show “Target Sign”

A

Fat

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16
Q

What are the common types of Tumor Matrix?

A
  • Nothing (purely lytic destruction)
  • Fat
  • Cartilage (Stippled, Flocculant, Arcs and Rings, or C/O Pattern Calcification)
  • Fibrous
  • Osseous (Diffuse or Focal)
17
Q

DDX for Diffuse Osseous matrix?

A

METs

18
Q

DDX for Focal Osseous matrix?

A

Osteoid Osteoma
Osteosarcoma

19
Q

Describe a Periosteal Reaction

A
  • AKA periostitis
  • Reactive new bone formation
  • Can have a 10-21 days latent period
20
Q

What causes Periosteal reactions?

A
  • Blood
  • Pyogenic material
  • Tumor
  • Hyperemia
  • Inflammation
21
Q

What are the 5 main types of Periosteal reaction?

A
  • Solid
  • Single layer
  • Laminated (onion skin or lamellated)
  • Spiculated (hair-on-end or sunburst)
  • Codman’s triangle
22
Q

What is the least aggressive Periosteal reaction?

A

Solid

23
Q

What is the most aggressive Periosteal reaction?

A

Codman’s triangle

24
Q

When do you order an MRI with contrast?

A
  1. Tumor
  2. Infection
  3. Inflammatory arthritis
  4. Post Surgical Fibrosis
25
Q

Describe a Benign Periosteal reaction

A

Chronic irritation that results in:
* Thick/dense appearance
* Lobulated to smooth margins

26
Q

Describe an Aggressive Periosteal reaction

A

Rapid irritation that results in:
* Lamellated, amorphous or sunburst

27
Q

Define Additional Imaging Modalities

A
  • CT
  • MRI (Tumor or Infection)
  • Ultrasound
  • Nuclear medicine (Bone scan, SPECT, PET/CT)
  • Lab tests
  • Biopsy
28
Q
A