Neoplasia - Paraneoplastic syndromes

Question 1

Cushing syndrome (4 tumors). Mechanism?

Answer 1

1. Small cell ca lung
2. Pancreatic tumors
3. Neural tumors
4. Renal carcinoma

Mech - ACTH or ACTH like substance

Question 2

SIADH

Answer 2

1. Small cell ca lung
2. Intracranial neoplasms

Mech: ADH

Question 3

Hypercalcemia

Answer 3

1. Squamous cell ca lung
2. Breast ca
3. Renal carcinoma
4. ATLL

Mech: Parathyroid hormone related protein, TNF, IL-1

Question 4

Hypoglycemia

Answer 4

1. Ovarian cancer
2. Fibrosarcoma

Mech: Insulin or insulin like substance

Question 5

Polycythemia

Answer 5

1. Renal carcinoma
2. Cerebellar hemangioma
3. Hepatocellular carcinoma

Mech: Erythropoetin

Question 6

Osteomalacia1

Answer 6

Phosphaturic mesenchymal tumor

Mech: FGF-23