Name the growth factors describe in lecture
PDGFB
(platelet drived growth factor beta)
Name the associated growth factor with the following tumor(s)
Astroctyoma (Glial cell)
define: func and mechanism
- PDGF-B
- fun: Platelet derived growth factor beta
- mech: Overexpression, autocrine loop
Name the 3 growth factor receptors discussed
- HER2/neu (ERBB2)
- RET
- KIT
Name the associated growth factor receptor with the following tumor(s)
subset of breast carcinomas
define: func and mechanism
- HER2/neu (ERRB2)
- fun: epidermal growth factor receptor
- mech: amplification
Name the associated growth factor receptor with the following tumor(s)
MEN2a, MEN2b, sporadice medullary carcinoma of the thyroid
define: func and mechanism
- RET
- Neural growth factor
- point mutation
Name the associated growth factor receptor with the following tumor(s)
Gastrointestinal stromal tumor
define: func and mechanism
- KIT
- fun: stem cell growth factor receptor
- mech: Point mutation
Name the associated singal transduction with the following tumor(s)
Gacrinomas, melanoma, lymphoma
define: func and mechanism
- RAS gene family
- fun: GTP-binding proteins
- mech: point mutation
Name the 2 signal transducers
- RAS gene family
- ABL
Name the associated signal transducers with the following tumor(s)
CML and some types of ALL (adult ALL philidelphia ALL)
define: func and mechanism
- ABL
- fun: Tyrosine kinase
- mech: t (9:22)
- w/BCR defines CML
Name the 3 nuclear regulators
- c-MYC
- N-MYC
- L-MYC
Name the associated nuclear regulator with the following tumor(s)
burkitt lymphoma
define: func and mechanism
- c-MYC
- fun: transcription factor
- mech: t(8:14) involving IgH
Name the associated nuclear regulator with the following tumor(s)
Neuroblastoma
define: func and mechanism
- N-Myc
- func: transcription factor
- mech: Amplification
Name the associated nuclear regulator with the following tumor(s)
Lung carcinoma (small cell)
define: func and mechanism
- L-Myc
- func: transcrition factor
- Amplification
name the 2 cell cycle regulators
- CCND1 (cyclin D1)
- CDK4
Name the associated nuclear regulator with the following tumor(s)
Mantle cell lymphoma
define: func and mechanism
- CCND1 (cell cyclin D1)
- func: cyclin
- mech: t (11,14)
Name the associated nuclear regulator with the following tumor(s)
Melanoma
define: func and mechanism
- CDK4
- fun: cyclin-dependant kinase
- mech: amplification
