Neoplasia I Flashcards
Define neoplasia
disorder of cell growth (can be benign or malignant)
What are some features of neoplasia?
triggered by a series of acquired mutations of single cell and its clones
monoclonal
autonomous
irreversible
What are the two basic components shared by all tumors?
parenchyma made of neoplastic cells that are neuroectodermal, epithelial, or mesenchymal in origin
stroma (connective tissue, blood vessels, immune cells –> the support of the neoplasm)
What is a teratoma?
a tumor that contains cells from more than one germ layer
What are the mesenchymal tissues of origin?
fibrous tissue chondroid osteoid blood vessels smooth muscle skeletal muscle lymphoid tissue hematopoietic cells
What is added to the end of a benign tumor of mesenchymal origin?
-oma
fibroma chondroma osteoma hemangioma leimyoma rhabdomyoma
What is added to the end of a malignant tumor of mesenchymal origin?
-sarcoma
fibrosarcoma chondrosarcoma osteosarcoma angiosarcoma leimyosarcoma rhabdomyosarcoma
What is a malignant tumor of lymphoid origin called?
lymphoma (doesn’t follow pattern)
What is a malignant tumor of hematopoietic origin called?
leukemia (doesn’t follow pattern)
What are the epithelial tissues of origin?
stratified squamous cells
epithelial lining of glands and ducts
What is added to the end of benign tumors of epithelial origin?
-oma
squamous papilloma
adenoma
What is added to the end of malignant tumors of epithelial origin?
-carcinoma
squamous cell carcinoma
adenocarcinoma
What is the morphology of a benign neoplasm?
well differentiated (resembles normal tissue counterpart) to dysplastic
What is the cell morphology of a malignant neoplasm?
well differentiated to very dedifferentiated (anaplastic)
pleomorphic (variation in nuclear size and shape)
abnormal nuclear morphology (high N/C ratio, hyperchromatic, prominent nucleoli)
mitoses
define dysplasia
disordered growth
