Neoplasia - CPC IV Flashcards
Formulate hypotheses about the disease process and diagnosis based on the information presented.
• 21-19 y/o
o Pap smear testing every 3 years
o Not recommended for HPV screening since most will regress on their own
• 30-65 y/o
o Pap smear testing every 5 years
o Co-testing for HPV
Discuss the role of HPV in cervical cancer.
• PAP Smear
o Inspect the transitional zone from columnar to squamous cells i
o Atypical Squamous Epithelium of Unknown Significance (ASCUS)
o Hyper-chromatic nuclei = positive
o 99% of cervical cancers = have HPV
o HPV 16, 18 & 45 most prevalent
- Viral DNA integrated into host genome
- E6 interacts with p53 and promotes p53 degradation
- E7 complexes with Rb, also involved in HPV
Discuss the psychological aspects of confronting a patient with the new diagnosis of cancer.
no answer
Explain the role molecular diagnostic techniques can play in detecting and protecting against medical error.
PAP Smear Results
- Normal
- ASCUS
- Low Grade Squamous Intra-epithelial Lesion
- High Grade Squamous Intra-epithelial Lesion
Cervical Biopsy Results
- CIN I: Mild dysplasia
- CIN II: Moderate dysplasia
- CIN II sever dysplasia
- Carcinoma-in-situ-treat
o Repeat PAP instead of HPV DNA test
o Colonoscopy with biopsy
o Colonoscopy with biopsy & treat
o Will spontaneously regress
o Treat
o Treat
o Treat
- Invasive cervical cancer
o Treat
