Neoplasia

Question 1

Leukoplakia ?

Answer 1

a mucous membrane disorder characterized by white patches, especially on the cheek , tongue , vulva or penis

Question 2

Premalignant (precancerous ) lesion ?

Answer 2

A group of conditions which predispose to the subsequent development of cancer

Question 3

Carcinoma in situ ( intraepithelial neoplasia ) ?

Answer 3

When the cytological features of malignancy are present but the malignant cell are confined to epithelium without invasion across the basement membrane

Question 4

What happen to the carcinoma in situ ?

Answer 4

It may regress and return to normal or may develop into invasive cancer

Question 5

Example of carcinoma in situ ?

Answer 5

(CIN) cervical intraepithelial neoplasia

Question 6

Mention premalignant lesion ?

Answer 6

Hyperplasia 
Dysplasia 
Metaplasia 
Inflammatory lesions 
Benign tumors

Question 7

Why its imporant to recognize premalignant condition ?

Answer 7

Because it is possible at this stage to completely eradicated the lesion

Question 8

Example of hyperplasia ?

Answer 8

1- Endometrial hyperplasia = endometrial carcinoma
2- breast lobular and ductal hyperplasia= breast carcinoma
3- cirrhosis of liver = hepatocellular carcinoma

Question 9

Example of dysplasia ?

Answer 9

1- Cervix = squamous carcinoma of cervix
2- skin= squamous carcinoma
3- bladder = transitional cell carcinoma
4- bronchial epithelium = lung carcinoma

Question 10

Example of metaplasia?

Answer 10

Grandular metaplasia of esophagus= adenocarciboma of esophagus

Question 11

Example of inflammatory lesions ?

Answer 11

1- ulcerative colitis = carcinoma of colon
2- atrophic gastritis = carcinoma of stomach
3- hashimoto’s thyroiditis = thyroid carcinoma

Question 12

Example of benign tumors ?

Answer 12

Colonic adenoma = carcinoma of colon

Neurofibroma = malignant of schwannoma ( MPNSTs) malignant peripheral nerve sheeth tumors

Question 13

Carcinoma in situ is a true neoplasm ?

Answer 13

Yes its a true neoplasm with all features of malignanancy except invasiveness

Question 14

Common sites of carcinoma in situ?

Answer 14

Uterine cervix
Oral leukoplakia
Interalobular and intraductal carcinoma of breast

Question 15

Example of carcinoma in situ ?

Answer 15

Bowen's disease of skin 
Actinic or solar keratoses 
Erythroplasia of queyrat 
Leukoplakia with dysplasia
Cervical dysplasia
Paget's disease of skin

Question 16

Bowen’ disease?

Answer 16

Bowen’s disease is a very early form of
skin cancer that’s easily treatable. The
main sign is a red, scaly patch on the
skin. It affects the squamous cells, which
are in the outermost layer of skin, and is
sometimes referred to as squamous cell
carcinoma in situ.

Question 17

Paget’s disease of skin?

Answer 17

Extra-mammaryPaget’s disease(EMPD) is a rare, slow-growingdiseasethat is a pre-invasive form ofskincancer. It looks similar to a patch of eczema and usually affectsskinin the genital area and around the anus. It is commonest in people aged over 50, with studies showing it peaks at around age 65

Question 18

Erythroplasia of queyrat?

Answer 18

Erythroplasia of Queyrat (EQ) (bower disease of the glans penis ) is an in situ squamous cell carcinoma of the penis.[1]The glans and prepuce are most commonly involved.[2]Erythroplasia of Queyrat is seen almost exclusively in uncircumcised men. Progression to invasive carcinoma may occur, and spontaneous regression is unlike

Question 19

Actinic or solar keratoses ?

Answer 19

Actinic keratoses(also calledsolar keratoses) are dry scaly patches of skin that have been damaged by the sun. The patches are not usually serious. But there’s a small chance they could become skin cancer, so it’s important to avoid further damage to your skin