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USMLE PATHOLOGY (MG) > NEOPLASIA > Flashcards

NEOPLASIA Flashcards

1
Q

BCR/ABL

Gene Product?
Associated Tumor?

A

Tyrosine Kinase
CML/ALL

(Oncogene)

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2
Q

BCL-2

Gene Product?
Associated Tumor?

A

Anti-apoptotic molecule (blocks apoptosis)
Follicular & undifferentiated lymphomas

(Oncogene)

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3
Q

BRAF

Gene Product?
Associated Tumor?

A

Serine/Threonine Kinase
Melanoma, non-Hodgkin Lymphoma

(Oncogene)

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4
Q

c-kit

Gene Product?
Associated Tumor?

A

Cytokine Receptor
Gastrointestinal Stomal Tumor (GIST)

(Oncogene)

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5
Q

c-myc

Gene Product?
Associated Tumor?

A

Transcription Factor
Burkitt Lymphoma

(Oncogene)

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6
Q

HER2/neu (c-erbB2)

Gene Product?
Associated Tumor?

A

Tyrosine Kinase
Breast, Ovarian & Gastric Carcinomas

(Oncogene)

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7
Q

L-myc

Gene Product?
Associated Tumor?

A

Transcription Factor
Lung Tumor

(Oncogene)

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8
Q

N-myc

Gene Product?
Associated Tumor?

A

Transcription Factor
Neuroblastoma

(Oncogene)

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9
Q

RAS

Gene Product?
Associated Tumor?

A

GTPase
Colon, Lung, Pancreatic CA

(Oncogene)

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10
Q

RET

Gene Product?
Associated Tumor?

A

Tyrosine Kinase
MEN 2A/2B, Medullary Thyroid CA

(Oncogene)

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11
Q

APC

Associated Tumor?

A

Colorectal CA (FAP associated)

Tumor Supressor Gene

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12
Q

BRCA1/BRCA2

Gene Product?
Associated Tumor?

A

DNA Repair Protein

Breast & Ovarian CA

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13
Q

DCC

Gene Product?
Associated Tumor?

A

DCC
Colon CA

“Deleted in Colon Cancer”

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14
Q

DPC4/SMAD4

Gene Product?
Associated Tumor?

A

DPC
Pancreatic CA

“Deleted in Pancreatic Cancer”

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15
Q

MEN1

Gene Product?
Associated Tumor?

A

Menin

MEN 1

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16
Q

NF1

Gene Product?
Associated Tumor?

A

Ras GTPase activating protein (neurofibromin)

NeuroFibromatosis Type 1 (NF1)

17
Q

NF2

Gene Product?
Associated Tumor?

A

Merlin (Schwannomin) Protein

NeuroFibromatosis Type 2 (NF2)

18
Q

p16

Gene Product?
Associated Tumor?

A

Cyclin-dependent kinase inhibitor 2A

Melanoma

19
Q

p53

Gene Product?
Associated Tumor?

A

TF for p21, Blocks G1 –> S phase

Most human CA, Li-Fraumeni Syndrome

20
Q

PTEN

Associated Tumor?

A

Breast, Prostate, Endometrial CA

21
Q

Rb

Gene Product?
Associated Tumor?

A

Inhibits E2F, Blocks G1 –> S phase

RetinoBlastoma (Rb), osteosarcoma

22
Q

TSC1

Gene Product?
Associated Tumor?

A

Hamartin Protein

Tuberous Sclerosis

23
Q

TSC2

Gene Product?
Associated Tumor?

A

Tuberin Protein

Tuberous Sclerosis

24
Q

VHL

Gene Product?
Associated Tumor?

A

Inhibits hypoxia inducible factor 1a

Von Hipple-Lindau Disease, Renal Cell CA

25
Q

WT1/WT2

Associated Tumor?

A

Wilms Tumor (Neuroblastoma, WT)

USMLE PATHOLOGY (MG) (1 decks)

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