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neoplasia > neoplasia > Flashcards

neoplasia Flashcards

1
Q

acanthosis nigricans

A

visceral malignancy

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2
Q

actinic keratosis

A

SCC of the skin

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3
Q

AIDS

A

Aggressive malignant lymphomas (non-hidgkins) and Kaposi

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4
Q

Auto-immune disease

A

Lymphoma

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5
Q

Barrett’s esophagus

A

Esophageal adenocarcinoma

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6
Q

Chronic atrophic gastritis, pernicious anemia, postsurgical gastric remnants

A

Gastric adenocarcinoma

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7
Q

Cirrhosis

A

Hepatocellular carcinoma

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8
Q

Cushing syndrome

A

Small cell lung cancer

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9
Q

Dermatomyositis

A

Lung cancer

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10
Q

Down syndrome

A

ALL and AML

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11
Q

Dysplastic nevus

A

malignant melanoma

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12
Q

Hypercalcemia

A

Squamous cell lung cancer

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13
Q

Immunodeficient states

A

Malignant lymphomas

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14
Q

Lambert-Eaton myasthenic syndrome

A

Small cell lung cancer

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15
Q

Myasthenia Gravis, pure RBC aplasia

A

Thymoma

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16
Q

Paget disease of bone

A

secondary osteosarcoma and fibrosarcoma

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17
Q

Plummer-Vinson syndrome (decreased iron)

A

Squamous cell carcinoma of esophagus

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18
Q

Polycythemia

A

Renal cell carcinoma, hepatocellular carcinoma

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19
Q

Radiation exposure

A

Leukemias, sarcomas, papillary thyroid cancer, breast cancer

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20
Q

SIADH

A

small cell lung cancer

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21
Q

Tuberous sclerosis

A

Giant cell astrocytoma, renal angiomyolipoma, cardiac rhabdomyoma

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22
Q

Ulcerative colitis

A

Colonic adenocarcinoma

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23
Q

Xeroderma pigmentosum, albinism

A

MElanoma, basal cell carcinoma, and especially SCC of skin

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24
Q

BCR-ABL (t9;22)

A

oncogene. tyrosine kinase. CML, ALL

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25
bcl-2 (t14;18)
oncogene. Anti-apoptotic molecule. Follicular lymphomas
26
BRAF
oncogene. serine/threonine kinase. Melanoma
27
c-kit
oncogene. Cytokine receptor. Gastrointestinal stromal tumor
28
HER2/neu (c-erbB2)
oncogene. Tyrosine kinase. Breast, ovarian, gastric carcinoma
29
c-myc (t8;14)
oncogene. Transcription factor. Burkitt lymphoma
30
L-myc
oncogene. transcription factor. Lung tumor
31
N-myc
transcription factor. Neuroblastoma
32
ras
oncogene. GTPase. colon cancer, lung cancer, pancreatic cancer
33
ret
oncogene. tyrosine kinase. MEN 2A and 2B.
34
APC (Chr5)
tumor suppressor. Colorectal cancer (FAP).
35
BRCA1 (Chr 17)
tumor suppressor. Breast and ovarian cancer. DNA repair protein.
36
BRCA2 (Chr 13)
tumor suppressor. Breast and ovarian cancer. DNA repair protein.
37
CPD4/SMAD4
tumor suppressor. Pancreatic cancer.
38
DCC (Chr 18)
tumor suppressor. Colon cancer.
39
MEN1
tumor suppressor. MEN type 1
40
NF1 (Chr 17)
tumor suppressor. Neurofibromatosis 1. RAS GTPase activating factor
41
NF2 (Chr 22)`
tumor suppressor. Neurofibromatosis 2. Merlin protein
42
p16
tumor suppressor. MElanoma. Cyclin-dependent kinase inhibitor 2A
43
p53 (Chr 17)
tumor suppressor. Most human cancers, Li-Fraumeni syndrome. transcription factor for p21, block G1 to S phase
44
PTEN
tumor suppressor. breast, prostate, and endometrial cancer.
45
Rb (Chr 13)
tumor suppressor. retinoblastoma, osteosarcoma. inhibits E2F, block G1 to S phase
46
TSC1
tumor suppressor. Tuberous sclerosis. Hamartin protein.
47
TSC2
tumor suppressor. Tuberous sclerosis. Tuberin protein
48
VHL (Chr 3)
tumor suppressor. von Hippel-Lindau disease. inhibits hypoxia inducible factor 1a
49
WT1/2 (Chr 11)
tumor suppressor. Wilms tumor (nephroblastoma)
50
cyclinD1 (t11;14)
oncogene. Mantel cell lymphoma
51
alkaline phosphatase
tumor marker. Metastasis to bone, liver, Pagets disease, seminoma (placental ALP)
52
alpha-fetoprotein
tumor marker. Hepatocellular carcinoma, hepatoblastoma, yolk-sac tumor, testicular cancer, mixed germ cell tumor, neural tube defects.
53
Beta-hCG
tumor marker. Hydratidiform mole, choriocarcinomas, testicular cancers.
54
CA-15-3/CA-27-9
tumor marker. Breast cancer
55
CA-19-9
tumor marker. Pancreatic adenocarcinoma
56
CA-125
tumor marker. Ovarian cancer
57
Calcitonin
tumor marker. Medullary thyroid cancer.
58
CEA
tumor marker. 70% of colorectal and pancreatic cancers. very nonspecific
59
PSA
tumor marker. prostatitis, BPH, prostate adenocarcinoma
60
S-100
tumor marker. Neural crest origin.
61
TRAP
tumor marker. Hairy cell leukemia
62
EBV
Burkitt's, Hodgkins, nasopharyngeal carcinoma, CNS lymphoma (immune comp)
63
HBV, HCV
hepatocellular carcinoma
64
HHV-8 (Kaposi sarcoma virus)
Kaposi sarcoma, body cavity fluid B-cell lymphoma
65
H. pylori
Gastric adenocarcinoma, MALT lymphoma
66
HTLV-1
Adult T-cell leukemia/lymphoma
67
Liver flukes (Clonorchis sinesis)
Cholangiocarcinoma
68
Schistosoma haematobium
Bladder cancer
69
Alfatoxin
hepatocellular carcinoma
70
Alkylating agents
leukemias/lymphomas
71
Aromatic amines (benzidine, 2-naphthylamine)
Transitional cell carcinoma (bladder)
72
Arsenic
Angiosarcoma (liver), Lung cancer, SCC (skin)
73
Asbestos
Bronchogenic carcinoma >mesothelioma
74
Carbon tetrachloride
Centrilobular necrosis, fatty changes in liver
75
Cigarette smoke
Transitional cell carcinoma (bladder), SCC/adenocarcinoma (esophagus), Renal cell carcinoma, SCC (larynx), SCC and small cell (lung), Pancreatic adenocarcinoma
76
Ethanol
Hepatocellular carcinoma
77
Ionizing raditation
Papillary thyroid cancer
78
Nitrosamines (smoked foods)
Gastric cancer
79
Radon
Lung cancer (2nd leading cause after smoking)
80
Vinyl chloride
Angiosarcoma (liver)
81
Paraneoplastic: 1,25-(OH)2-D3 (calcitriol)
Hypercalcemia. Hodgkins and some non-Hodgkins
82
Paraneoplastic: ACTH
Cushing syndrome. Small cell lung cancer and some intracranial neoplasms
83
Paraneoplastic: ADH
SIADH. Small cell lung cancer
84
Paraneoplastic: anti-bodies against presynaptic Ca2+ channels at NMJ
Lambert-Eaton myasthenic syndrome. Small cell lung cancer
85
Paraneoplastic: Erythropoietin
Polycythemia. Renal cell carcinoma, Thymoma, hemangioma, hepatocellular carcinoma, leiomyoma, pheochromocytoma.
86
Paraneoplastic: PTHrP
Hypercalcemia. SCC lung, renal cell carcinoma, breast cancer.
87
Psammoma bodies
Papillary thyroid cancer, serous papillary cystadenocarcinoma of ovary, meningioma, malignant mesothelioma.

neoplasia (1 decks)

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