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neoplasia > neoplasia > Flashcards

neoplasia Flashcards

1
Q

acanthosis nigricans

A

visceral malignancy

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2
Q

actinic keratosis

A

SCC of the skin

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3
Q

AIDS

A

Aggressive malignant lymphomas (non-hidgkins) and Kaposi

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4
Q

Auto-immune disease

A

Lymphoma

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5
Q

Barrett’s esophagus

A

Esophageal adenocarcinoma

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6
Q

Chronic atrophic gastritis, pernicious anemia, postsurgical gastric remnants

A

Gastric adenocarcinoma

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7
Q

Cirrhosis

A

Hepatocellular carcinoma

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8
Q

Cushing syndrome

A

Small cell lung cancer

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9
Q

Dermatomyositis

A

Lung cancer

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10
Q

Down syndrome

A

ALL and AML

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11
Q

Dysplastic nevus

A

malignant melanoma

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12
Q

Hypercalcemia

A

Squamous cell lung cancer

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13
Q

Immunodeficient states

A

Malignant lymphomas

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14
Q

Lambert-Eaton myasthenic syndrome

A

Small cell lung cancer

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15
Q

Myasthenia Gravis, pure RBC aplasia

A

Thymoma

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16
Q

Paget disease of bone

A

secondary osteosarcoma and fibrosarcoma

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17
Q

Plummer-Vinson syndrome (decreased iron)

A

Squamous cell carcinoma of esophagus

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18
Q

Polycythemia

A

Renal cell carcinoma, hepatocellular carcinoma

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19
Q

Radiation exposure

A

Leukemias, sarcomas, papillary thyroid cancer, breast cancer

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20
Q

SIADH

A

small cell lung cancer

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21
Q

Tuberous sclerosis

A

Giant cell astrocytoma, renal angiomyolipoma, cardiac rhabdomyoma

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22
Q

Ulcerative colitis

A

Colonic adenocarcinoma

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23
Q

Xeroderma pigmentosum, albinism

A

MElanoma, basal cell carcinoma, and especially SCC of skin

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24
Q

BCR-ABL (t9;22)

A

oncogene. tyrosine kinase. CML, ALL

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25
Q

bcl-2 (t14;18)

A

oncogene. Anti-apoptotic molecule. Follicular lymphomas

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26
Q

BRAF

A

oncogene. serine/threonine kinase. Melanoma

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27
Q

c-kit

A

oncogene. Cytokine receptor. Gastrointestinal stromal tumor

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28
Q

HER2/neu (c-erbB2)

A

oncogene. Tyrosine kinase. Breast, ovarian, gastric carcinoma

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29
Q

c-myc (t8;14)

A

oncogene. Transcription factor. Burkitt lymphoma

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30
Q

L-myc

A

oncogene. transcription factor. Lung tumor

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31
Q

N-myc

A

transcription factor. Neuroblastoma

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32
Q

ras

A

oncogene. GTPase. colon cancer, lung cancer, pancreatic cancer

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33
Q

ret

A

oncogene. tyrosine kinase. MEN 2A and 2B.

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34
Q

APC (Chr5)

A

tumor suppressor. Colorectal cancer (FAP).

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35
Q

BRCA1 (Chr 17)

A

tumor suppressor. Breast and ovarian cancer. DNA repair protein.

36
Q

BRCA2 (Chr 13)

A

tumor suppressor. Breast and ovarian cancer. DNA repair protein.

37
Q

CPD4/SMAD4

A

tumor suppressor. Pancreatic cancer.

38
Q

DCC (Chr 18)

A

tumor suppressor. Colon cancer.

39
Q

MEN1

A

tumor suppressor. MEN type 1

40
Q

NF1 (Chr 17)

A

tumor suppressor. Neurofibromatosis 1. RAS GTPase activating factor

41
Q

NF2 (Chr 22)`

A

tumor suppressor. Neurofibromatosis 2. Merlin protein

42
Q

p16

A

tumor suppressor. MElanoma. Cyclin-dependent kinase inhibitor 2A

43
Q

p53 (Chr 17)

A

tumor suppressor. Most human cancers, Li-Fraumeni syndrome. transcription factor for p21, block G1 to S phase

44
Q

PTEN

A

tumor suppressor. breast, prostate, and endometrial cancer.

45
Q

Rb (Chr 13)

A

tumor suppressor. retinoblastoma, osteosarcoma. inhibits E2F, block G1 to S phase

46
Q

TSC1

A

tumor suppressor. Tuberous sclerosis. Hamartin protein.

47
Q

TSC2

A

tumor suppressor. Tuberous sclerosis. Tuberin protein

48
Q

VHL (Chr 3)

A

tumor suppressor. von Hippel-Lindau disease. inhibits hypoxia inducible factor 1a

49
Q

WT1/2 (Chr 11)

A

tumor suppressor. Wilms tumor (nephroblastoma)

50
Q

cyclinD1 (t11;14)

A

oncogene. Mantel cell lymphoma

51
Q

alkaline phosphatase

A

tumor marker. Metastasis to bone, liver, Pagets disease, seminoma (placental ALP)

52
Q

alpha-fetoprotein

A

tumor marker. Hepatocellular carcinoma, hepatoblastoma, yolk-sac tumor, testicular cancer, mixed germ cell tumor, neural tube defects.

53
Q

Beta-hCG

A

tumor marker. Hydratidiform mole, choriocarcinomas, testicular cancers.

54
Q

CA-15-3/CA-27-9

A

tumor marker. Breast cancer

55
Q

CA-19-9

A

tumor marker. Pancreatic adenocarcinoma

56
Q

CA-125

A

tumor marker. Ovarian cancer

57
Q

Calcitonin

A

tumor marker. Medullary thyroid cancer.

58
Q

CEA

A

tumor marker. 70% of colorectal and pancreatic cancers. very nonspecific

59
Q

PSA

A

tumor marker. prostatitis, BPH, prostate adenocarcinoma

60
Q

S-100

A

tumor marker. Neural crest origin.

61
Q

TRAP

A

tumor marker. Hairy cell leukemia

62
Q

EBV

A

Burkitt’s, Hodgkins, nasopharyngeal carcinoma, CNS lymphoma (immune comp)

63
Q

HBV, HCV

A

hepatocellular carcinoma

64
Q

HHV-8 (Kaposi sarcoma virus)

A

Kaposi sarcoma, body cavity fluid B-cell lymphoma

65
Q

H. pylori

A

Gastric adenocarcinoma, MALT lymphoma

66
Q

HTLV-1

A

Adult T-cell leukemia/lymphoma

67
Q

Liver flukes (Clonorchis sinesis)

A

Cholangiocarcinoma

68
Q

Schistosoma haematobium

A

Bladder cancer

69
Q

Alfatoxin

A

hepatocellular carcinoma

70
Q

Alkylating agents

A

leukemias/lymphomas

71
Q

Aromatic amines (benzidine, 2-naphthylamine)

A

Transitional cell carcinoma (bladder)

72
Q

Arsenic

A

Angiosarcoma (liver), Lung cancer, SCC (skin)

73
Q

Asbestos

A

Bronchogenic carcinoma >mesothelioma

74
Q

Carbon tetrachloride

A

Centrilobular necrosis, fatty changes in liver

75
Q

Cigarette smoke

A

Transitional cell carcinoma (bladder), SCC/adenocarcinoma (esophagus), Renal cell carcinoma, SCC (larynx), SCC and small cell (lung), Pancreatic adenocarcinoma

76
Q

Ethanol

A

Hepatocellular carcinoma

77
Q

Ionizing raditation

A

Papillary thyroid cancer

78
Q

Nitrosamines (smoked foods)

A

Gastric cancer

79
Q

Radon

A

Lung cancer (2nd leading cause after smoking)

80
Q

Vinyl chloride

A

Angiosarcoma (liver)

81
Q

Paraneoplastic: 1,25-(OH)2-D3 (calcitriol)

A

Hypercalcemia. Hodgkins and some non-Hodgkins

82
Q

Paraneoplastic: ACTH

A

Cushing syndrome. Small cell lung cancer and some intracranial neoplasms

83
Q

Paraneoplastic: ADH

A

SIADH. Small cell lung cancer

84
Q

Paraneoplastic: anti-bodies against presynaptic Ca2+ channels at NMJ

A

Lambert-Eaton myasthenic syndrome. Small cell lung cancer

85
Q

Paraneoplastic: Erythropoietin

A

Polycythemia. Renal cell carcinoma, Thymoma, hemangioma, hepatocellular carcinoma, leiomyoma, pheochromocytoma.

86
Q

Paraneoplastic: PTHrP

A

Hypercalcemia. SCC lung, renal cell carcinoma, breast cancer.

87
Q

Psammoma bodies

A

Papillary thyroid cancer, serous papillary cystadenocarcinoma of ovary, meningioma, malignant mesothelioma.

neoplasia (1 decks)

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