Neoplasia Flashcards by AFD Alvarez

Q

A

Villous Polyp, Colon

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Q

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Villous Polyp, Colon

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Q

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Villous Polyp, Colon

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Q

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Normal Colon - Villous Polyp, Colon

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Q

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Villous Polyp, Colon

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Q

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Villous Polyp, Colon

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Villous Polyp, Colon

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Villous Polyp, Colon - Stratified and elongated nucleus

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Q

A

Villous Polyp, Colon

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Q

A

Villous Polyp, Colon

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Q

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Villous Polyp, Colon

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Adenomatous Polyp, Colon

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Q

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Adenomatous Polyp, Colon

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Q

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Adenomatous Polyp, Colon

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Q

A

Thyroid Adenoma (Follicular Adenoma)
Microfollicle

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Q

A

Thyroid Adenoma (Follicular Adenoma)

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Q

A

Thyroid Adenoma (Follicular Adenoma)

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Q

A

Thyroid Adenoma (Follicular Adenoma)

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Q

Diagnosis

A

Cardiac Myxoma

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Q

Give 2 types of cells visible

A

Myxoma cells & Hemosiderin-laden macrophages

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Q

Origin of neoplasia

A

Primitive multipotent mesenchymal cells

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Q

Genetic Mutation

A

Activation of GNAS1 mutation in McCune-Albright Syndrome or Carney complex

Q

Common Location

A

Left atrium (atrial septum)

Q

What do you call the acidic background

A

Myxoid stroma

What is the malignant counterpart?

(Cardiac) carcinosarcoma

What is the malignant counterpart?

(Cardiac) carcinosarcoma

Myxoid background is composed of

Mucopolysaccharides - chondroitin sulfate and hyaluronic acid

Diagnosis

Lipoma

Origin

Adipose tissue/ Adipocytes

Location

Subcutis from extremities or trunks

Malignant form

Liposarcoma

Diagnosis

Schwannoma *benign nerve sheath tumor*

Origin

- Differentiated schwann cells - neural crests

Location

Peripheral nerves

Gene mutation

- Loss of function in Merlin (tumor suppressor gene) - mutation in gene NF2

Characteristic appearance

Diphasic appearance: - Antoni A (hypercellular area - palisading areas) - Antoni B (hypocellular area)

Another name Antoni A

Verocay bodies

Malignant form

Malignant peripheral nerve sheath tumor

Diagnosis

Osteochondroma aka exostosis

Origin

Cartilage

Location

Metaphysis of distal femur, pelvis

Genetic Mutation

- Loss of function in EXT1, EXT2 (*in multiple hereditary exostosis*) - heterozygous mutations in IDH1 and IDH2 gene Osteochondroma

Malignant form

Chondrosarcoma

Diagnosis

Leiomyoma

Origin

Smooth muscle if the uterus

Location

- subserosal - intramural - submucosal

Gene mutation

- rearrangement in HMGI-C and HMGI-Y - mutations in MED12 gene

Patterns present

- circular - singular longitudinal

Malignant form

Leiomyosarcoma

Associated with what type of growth

Endochondral ossification

Diagnosis

Adenomatous polyp

Genetic mutation

Loss of function APC at 5q21

Descriptions of adenomas

- tubular adenomas - tubulo-villous adenomas - villous adenoma