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.General Pathology > Neoplasia > Flashcards

Neoplasia Flashcards

1
Q
A

Villous Polyp, Colon

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2
Q
A

Villous Polyp, Colon

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3
Q
A

Villous Polyp, Colon

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4
Q
A

Normal Colon - Villous Polyp, Colon

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5
Q
A

Villous Polyp, Colon

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6
Q
A

Villous Polyp, Colon

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7
Q
A

Villous Polyp, Colon

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8
Q
A

Villous Polyp, Colon - Stratified and elongated nucleus

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9
Q
A

Villous Polyp, Colon

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10
Q
A

Villous Polyp, Colon

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11
Q
A

Villous Polyp, Colon

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12
Q
A

Adenomatous Polyp, Colon

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13
Q
A

Adenomatous Polyp, Colon

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14
Q
A

Adenomatous Polyp, Colon

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15
Q
A

Thyroid Adenoma (Follicular Adenoma)
Microfollicle

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16
Q
A

Thyroid Adenoma (Follicular Adenoma)

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17
Q
A

Thyroid Adenoma (Follicular Adenoma)

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18
Q
A

Thyroid Adenoma (Follicular Adenoma)

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19
Q

Diagnosis

A

Cardiac Myxoma

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20
Q

Give 2 types of cells visible

A

Myxoma cells & Hemosiderin-laden macrophages

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21
Q

Origin of neoplasia

A

Primitive multipotent mesenchymal cells

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22
Q

Genetic Mutation

A

Activation of GNAS1 mutation in McCune-Albright Syndrome or Carney complex

23
Q

Common Location

A

Left atrium (atrial septum)

24
Q

What do you call the acidic background

A

Myxoid stroma

25
Q

What is the malignant counterpart?

A

(Cardiac) carcinosarcoma

26
Q

What is the malignant counterpart?

A

(Cardiac) carcinosarcoma

27
Q

Myxoid background is composed of

A

Mucopolysaccharides - chondroitin sulfate and hyaluronic acid

28
Q

Diagnosis

A

Lipoma

29
Q

Origin

A

Adipose tissue/ Adipocytes

30
Q

Location

A

Subcutis from extremities or trunks

31
Q

Malignant form

A

Liposarcoma

32
Q

Diagnosis

A

Schwannoma
benign nerve sheath tumor

33
Q

Origin

A
  • Differentiated schwann cells
  • neural crests
34
Q

Location

A

Peripheral nerves

35
Q

Gene mutation

A
  • Loss of function in Merlin (tumor suppressor gene)
  • mutation in gene NF2
36
Q

Characteristic appearance

A

Diphasic appearance:
- Antoni A (hypercellular area - palisading areas)
- Antoni B (hypocellular area)

37
Q

Another name Antoni A

A

Verocay bodies

38
Q

Malignant form

A

Malignant peripheral nerve sheath tumor

39
Q

Diagnosis

A

Osteochondroma aka exostosis

40
Q

Origin

A

Cartilage

41
Q

Location

A

Metaphysis of distal femur, pelvis

42
Q

Genetic Mutation

A
  • Loss of function in EXT1, EXT2 (in multiple hereditary exostosis)
  • heterozygous mutations in IDH1 and IDH2 gene

Osteochondroma

43
Q

Malignant form

A

Chondrosarcoma

44
Q

Diagnosis

A

Leiomyoma

45
Q

Origin

A

Smooth muscle if the uterus

46
Q

Location

A
  • subserosal
  • intramural
  • submucosal
47
Q

Gene mutation

A
  • rearrangement in HMGI-C and HMGI-Y
  • mutations in MED12 gene
48
Q

Patterns present

A
  • circular
  • singular longitudinal
49
Q

Malignant form

A

Leiomyosarcoma

50
Q

Associated with what type of growth

A

Endochondral ossification

51
Q

Diagnosis

A

Adenomatous polyp

52
Q

Genetic mutation

A

Loss of function APC at 5q21

53
Q

Descriptions of adenomas

A
  • tubular adenomas
  • tubulo-villous adenomas
  • villous adenoma

.General Pathology (6 decks)

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