Neoplasia

Question 1

It means “new growth”

Answer 1

Neoplasia

Question 2

This is the collection of cells and stroma composing new growths

Answer 2

Neoplasms

Question 3

This is the swelling caused by inflammation, but is equated with neoplasm

Answer 3

Tumor

Question 4

Study of tumors or neoplasms

Answer 4

Oncology

Question 5

What are the two components of tumors?

Answer 5

1. Neoplastic Cells
2. Reactive Stroma

Question 6

Abundant collagenous stroma stimulated by parenchymal cells

Answer 6

Desmoplasia

Question 7

A type of tumors which remain localized at their site of origin and are generally amenable to surgical removal.

Answer 7

Bengin Tumors

Question 8

A benign tumor of fibroblast like cells

Answer 8

FIbroma

Question 9

A benign cartilaginous tumor

Answer 9

Chondroma

Question 10

A benign epithelial neoplasms derived from glandular tissues. - Even if the tumor cells fail to form glandular sturctures

Answer 10

Adenoma

Question 11

A benign epithelial neoplasm producing fingerlike or wart projections from epithelial surfaces.

Answer 11

Papillomas

Question 12

Those that form large cystic masses such as in the ovary.

Answer 12

Cystadenoma

Question 13

A type of tumor that can invade and destroy adjacent structures and spread to distant sites (metastasize)

Answer 13

Malignant tumors

Question 14

Malignant tumors arising in solid mesenchymal tissues

Answer 14

Sarcomas

e.g. Fibrosarcoma/ Chondrosarcoma

Question 15

Malignant tumors arising from blood forming cells

Answer 15

Leukemia/ Lymphoma

Question 16

Malignant neoplasms of epithelial cell origin

Answer 16

Carcinomas

Question 17

Tumor cells resemble stratified squamous epithelium

Answer 17

Squamous cell carcinoma

Question 18

Neoplastic epithelial cells grow in a glandular pattern

Answer 18

Adenocarcinoma

Question 19

This contains recognizable mature or immature cells or tissues belonging to more than one germ cell layer

Answer 19

Teratoma

Question 20

A cystic tumor lined by squamous epithelium that is filled with hair, sebacous glands and tooth structures.

Answer 20

Ovarian cystic teratoma (Dermoid cyst)

Question 21

DIsorganized masses composed of cells indigenous to the involved tissue

Answer 21

Hamartomas

Now considered a benign neoplasm

Question 22

A heterotropic (misplaced) rest of cells such as normally organized pancreatic tissue found in the submucosa of the stomach or small intestine

Answer 22

Choristoma

Question 23

Differentiation and Anaplasia

The extent to which neoplastic parenchymal cells resemble the corresponding normal parenchymal cells, both morphologically and functionally.

Answer 23

Differentiation

Question 24

Lacks differentiation

Answer 24

Anaplasia

Question 25

There are 4 morphologic tell tale changes found in cancer cells

Answer 25

1. Pleomorphism
2. Abnormal Nuclear Morphology
3. Mitoses - Reflect high rate of proliferation
4. Loss of polarity

Question 26

Pleomorphism

Answer 26

> A variation in cell size and shape.
Cells within the sam etumor are not uniform.
They range from small cells with an undiffirentiated appearance to tumor giant cells larger than their neighbors.

Question 27

Abnormal nuclear morphology

Answer 27

> Cancer cells have nuclei that are disporportionately large, with a nuclear to cytoplasm ratio that may approach 1:1 instead of normal 1:4 to 1:6
Shape is variable send often irregular
Chromatin = coarsley clumped, hyperchromatic
Large nucleoli

Question 28

Loss of polarity

Answer 28

> The orientation of anaplastic cells with repsect to each other or to supporting structures like basement membranes is marekdly disturbed.

Tumor cells grow in a disorganized fashion

Question 29

Metaplasia

Answer 29

The replacement of one type of cell with another type.

Question 30

Barret Esophagus

Answer 30

Gastroesophageal reflux damages the squamous eptithelium of the esophagus, leading to its replacement by glandular epithelium better suited to an acidic env ironment.