Neoplasia 1 Flashcards
Adenoma
Benign epithelial tumor of the glands
Papilloma
Benign epithelial tumor of skin; projects outwards
Polyp
Benign epithelial tumor of mucosal surface (GI tract, nasal cavity, etc.)
Carcinoma
Malignant epithelial tumor
Describe the shape of epithelial tumor cells
Polygonal, cuboidal, or columnar
Describe the arrangement of epithelial tumor cells
Group together: nests, cords, islands, acini/tubular/glandular structures
Schirrous/desmoplastic reaction
Firm growth caused by normal fibroblasts “turned on” by tumor
Sign of EPITHELIAL tumor
Carcinoma in situ
Carcinoma that does not penetrate the basement membrane
Tissues derived from ectoderm
Skin (epidermis) Lining (nose, mouth, and anus) Eye Enamel Mammary gland Pituitary and pineal glands Inner ear Nerves Medulla of adrenal gland
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Tissues derived from mesoderm
Dermis Notochord Fat Muscle Reproductive system Dentin (teeth) Urinary system Skeleton Blood Connective tissue
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Tissues derived from endoderm
Thymus Pancreas Auditory tube Liver Prostate G.I. tract Respiratory (including lung) Thyroid
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Where do squamous cell carcinomas occur? Describe their gross and histological appearance.
Locations: Cat tongue and squamous part of horse stomach
Gross appearance:
- Lobular
- Angry red color on tongue (ulceration)
Histological appearance:
- Keratin pearls: dark pink “bulls-eye” w/ few nuclei
Cytokeratins
- Intermediate filaments in epithelial cells
- Stain BROWN by immunohistochemistry
Three histological features of mesenchymal tumors
- Spindle-shaped cells
- Arranged in streams, bundles, and whorls
- Produce stroma/matrix (osteoid, chondroid, collagen) IF BENIGN
“Hemangio-“
Endothelium