Neonatology Flashcards

1
Q

What are the main steps in neonatal resuscitation

A

Warm the baby
Calculate APGAR 1,5,10 mins
Stimulate breathing - dry vigorously with a towel- seep head neutral, check for obstruction

Give inflation breaths when baby is gasping or not breathing
2 cycles of 5 inflation breaths (3 secs each)

-If no response 30 secs of ventilation breaths

-No response then chest compressions - if HR below 60 despite resus - 3:1 ratio of compressions

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2
Q

What are the features in the APGAR score

A

Appearance- 0 if blue/ pale, 1 if blue extremities, 2 if pink

Pulse- 0 if absent, 1 if <100, 2 if >100

Grimmace- 0 if no response, 1 if little response, 2 if good response

Activity (muscle tone)- 0 if floppy, 1 if flexed arms and legs, 2 if active

Respiration - 0 if absent, 1 if slow and irregular, 2 if strong and crying

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3
Q

What 9 congenital conditions are looked at in the blood spot screening

A

Taken on day 5-8
Heel prick

-Sickle cell disease
-Cystic fibrosis
-Congenital hypothyroidism
-Phenylketonuria
-Medium chain acyl coA dehydrogenase deficiency
-Maple syrup urine disease
-Isovaleric acidaemia
-Glutaric acuduria
-Homocystin

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4
Q

How are preductal and post ductal oxygen sats measured

A

Pre ductal sats are from the right hand- right hand receives blood from arteries from the aorta before the ductus arteriosus

Post ductal sats - measured in either foot- they receive blood from the descending aorta after the ductus arteriosus

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5
Q

What are the features of talipes (club foot)

A

Positional- muscles are tight around the ankle- no bones affected - Physio

Structural - Bones of foot and ankle need surgery

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6
Q

What is a haemangioma and how is it treated

A

Blood vessels under the skin form a lump

Monitor and resolve with time

If affected eyes, mouth or airway can give propranolol

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7
Q

What is a port wine stain

A

Pink patches of skin on face
Don’t fade with time and turn darker red or purple

Can be related to storage-weber syndrome

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8
Q

What is a caput succedaneum and how is it managed

A

-Fluid collection on scalp outside the periosteum
-Pressure during a prolonged/ instrumental delivery
-Able to cross suture lines
-Will resolve in a few days

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9
Q

What is a cephalohaematoma

A

-Traumatic subperiosteal haematoma
-Blood collection between skull and periosteum
-Prolonged/ instrumental delivery
-Lump does not cross suture lines
-Discolouration of skin
-Will resolve in a few months
-Risk of anaemia and jaundice as blood collection breaks down

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10
Q

What are the features of Erb’s palsy

A

Injury to C5/C6
Associated with shoulder dystocia, traumatic/ instrumental delivery

Waiters tip appearance
Internally rotated shoulder, extended elbow, pronated wrist and no movement in arm

Spontaneously resolves in a few months

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11
Q

What are the most common bacteria responsible for neonatal sepsis

A

Group B strep
E colii
Listeria
Klebsiella
Staph aureus

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12
Q

What are the risk factors for neonatal sepsis

A

Vaginal GBS colonisation
GBS sepsis in previous baby
Maternal sepsis, choiroamnionitis or fever >38
Premature <37
Early rupture of membranes
Prolonged rupture of membranes

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13
Q

What are the symptoms of neonatal sepsis

A

Fever, reduced tone, poor feeding, apnoea/ resp distress, vomiting, tachycardia/ brady, hypoxia, jaundice, seizures, hypoglycaemia

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14
Q

What is the management for presumed neonatal sepsis

A

-1 risk factor or clinical feature- monitor obstruction for 12 hrs

-2 risk factors/ features- start abx

Abx started if there is a single red flag symptoms - within 1 hour of decision being made

-Cultures taken before abx

-Do lumbar puncture if infection strongly susuepcted/ there are features of meningitis

Benzylpenicillin and gentamicin are first line abx

Cefotaxime can be an alternative

Continue to check CRP and Cultures after 36 hours

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15
Q

What are the causes and features of hypoxic ischaemic encephalopathy

A

Hypoxia during birth - ischaemic brain damage can cause cerebral palsy

Causes
Maternal shock
Intrapartum haemorrhage
Prolapse cord (compression during birth)
Nuchal cord- wrapped around neck of baby

Babies near/ at term can get therapeutic hypothermia to 33-34 decrees for 72 hrs- reduce inflam and neurone loss

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16
Q

What is the staging of hypoxic ischaemic encephalopathy

A

Mild- poor feeding, generally irritable, hyper alert, resolves in 24 hrs, normal prognosis

Moderate- Poor feeding, lethargy, seizures, can take weeks to resolve- 40% cerebral palsy

Severe- LOC, apnoea, flaccid, no reflexes, 50% morality, 90% cerebral palsy

17
Q

What are the causes of neonatal jaundice

A

Increased bilirubin production (RBC broken down)
-Haemolytic disease of newborn
-ABO incompatibility
-Haemorrhage
-Intraventricular haemorrhage
-Cephalohaematoma
-Polycythaemia
-Sepsis and DIC
-G6PD deficiency

Decreased bilirubin clearance
-Premature
-Breast milk jaundice
-Neonatal cholestasis
-Extrahepatic biliary atresia
-Endocrine disorders
-Gilbert syndrome

18
Q

When is jaundice considered prolonged

A

More than 14 days in full term babies

More than 21 days in premature babies

Prompt investigations- biliary atresia, hypothyroid or G6PD deficiency

19
Q

How is neonatal jaundice managed

A

Phototherapy- blue light
Measure rebound bilirubin 12-18 hrs after

20
Q

What is kernicterus

A

Brain damage caused by excessive bilirubin levels
Bil can cross the BBB - damage the CNS

Floppy drowsy baby with poor feeding

Can cause cerebral palsy, learning disability and deafness

21
Q

What is the management of prematurity before birth

A

Women with history of preterm birth/ ceramic length of 25mm before 24 weeks give
-Prophylactic vaginal progesterone
-Propylactic cervical cerclage

When preterm labour is confirmed
-Tocolysis with nifendipine- surprise labour
-Maternal corticosteroids- before 35 weeks
-IV magnesium sulphate before 34 weeks
-Delayed cord clamping

22
Q

What are the features of apnoea of prematurity

A

Periods when baby stops breathing for more than 20 secs (shorter with oxygen desaturation/ bradycardia)

Causes
-Immaturity of the autonomic system
-Sign of developing illness- infection, anaemia, airway obstruction, CNS pathology (seizures/ haemorrhage), GORD, neonatal abstinence syndrome

Management
Apnoea monitors on premature babies
Tactile stimulation
IV caffeine

23
Q

What are the features of retinopathy of prematurity

A

Babies born before 32 weeks
Abnormal retinal blood vessel development - normally occurs due to hypoxia in utero which is disrupted if born prematurely - scarring, retinal detachment, blindness

Assessment of the retina in 3 zones
Disease described stage 1 (slight abnormal vessel growth) to stage 5 (completed retinal detachment)

Screening
Babies born before 32 weeks or under 1.5kg are screened
At 30-31 weeks if born before 27 weeks
4-5 weeks after birth if after 27 weeks

Treatment
Transpupillary laser photocoagulation
Cryotherapy
Injections of VEGF inhibitors
Surgery if retinal detachment

24
Q

What are the features and management of respiratory distress syndrome

A

Below 32 weeks and ground glass appearance on CXR

Inadequate surfactant- high surface tension in alveoli- lung collapse (atelectasis) - lack of gas exchange

Management
Antenatal steroids (dex) given to mothers in preterm labour

-Intubation and ventilation
-Endotracheal surfactant
-CPAP
-Supplemental 02- keep sats at 91-95%

25
Q

What are the features and management of necrotising entercoliitis

A

Premature neonates where bowel becomes necrotic
Emergency

Presentation
Intolerance to feeds
Green bilious vomiting
Distended tender abdomen
Absent bowel sounds
Blood in stools

Investigations
Abdo x-ray will show
Dilated loops of bowel
Bowel wall oedema (thickened walls)
Pneumatosis intestinal (gas in bowel wall)
Pneumoperitoenum

Management
NBM, IV fluids, TPN, antibiotics
NG tube
Immediate referral to surgical team

26
Q

What are the features of neonatal abstinence syndrome

A

Withdrawl symptoms of substances mother used pregnancy

Opiates, methadone, bentos, cocaine, amphetamines, nicotine/cannabis, alcohol, SSRIs

Symptoms
Opiates, dIAZEPAM , SSRIs and alcohol- 3-72 hrs
Methadone and other benzos take up to 3 weeks

Irritable, increased tone, high pitched cry, won’t settle, tremors, seizures, yawning, sweating, unstable temp, hypoglycaemia, loose stools

Monitored on NAS chart for 3 days
Urine sample to test for substances

Opiate withdrawl- give oral morphine sulphate

Non-opiate withdrawn give phenobarbitone

Safeguarding etc

27
Q

What are the features of fetal alcohol syndrome

A

-Microcephaly
-Thin upper lip
-Smooth flat philtre (between lip and nose)
-Short eye distance
-Learning disability
-behaviour issues
-Hearining/ vision issues
-Cerebral palsy

28
Q

What are the features of congenital rubella syndrome

A

Congenital cataracts
Congenital heart disease (PDA and pulmonary stenosis)
Learning disability
Hearing loss

29
Q

What are the features of congenital varicella syndrome

A

Fetal growth restriction
Microcephaly, hydrocephalus, learning disability
Scans and skin changes on dermatomes
Limb hypoplasia (underdevelopment)
Cataracts and eye inflam (chorioretinitis)

30
Q

What are the features of congenital cytomegalovirus

A

Fetal growth restriction
Microcephaly
Hearing/ Vision loss
Learning disability
Seizure

31
Q

What are the features of congenital toxoplasmosis

A

Triad
Intracranial calcification
Hydrocephalus
Chorioretinitis

32
Q

What are the features of congenital zika syndrome

A

Microcephaly
FGR
Intracranial abnormalitis- ventriculomegaly/ cerebellar atrophy

33
Q

What are the risk factors for sudden infant death syndrome and how is the risk minimised

A

First 6 months of life

Prematurity
Low birth weight
Smoking in pregnancy
Male baby

Baby on back when not directly supervised
Keep head uncovered
Feet at foot of bed- stop sliding under blanket
Keep cot clear of toys and blankets
Comfortable temp 16-20
Avoid smoking and handling baby after smoking
Avoid co-sleeping

Support
Lullaby tryst
Care of next infant team