NEONATAL PHARM DOSES

Question 1

BPD - dexamethasone

Answer 1

0.25mg/kg/dose IV BID x 3 days –gradually taper by 10% every 3 days …

Taper over 12-21 days – total of 42 days is possible

Question 2

BPD - Furosemide

IV and PO

Answer 2

IV- (0.5mg-1mg/kg/dose) – max 2mg/kg/dose Q24….can change to Q12.
or > 1month Q6-8 hours

PO- (1mg-2mg/kg/dose)- (double the IV dose-up to 6mg/kg/dose)

Question 3

BPD – Chlorothiazide (Diuril)

Answer 3

Dose-
< 6months : (20-40mg/kg/day) po divided every 12 hours (max 375mg/day)

> 6 months: (20mg/kg/day) po divided every 12 hrs (max 1 gram)

Question 4

BPD Spirolactone (aldactone)

Answer 4

Dose (1-3mg/kg/day) po Q 24hours – 2mg/kg/d typical

Question 5

BPD - Bronchodilators

Albuterol

Answer 5

DOSE- nebulizer – (2.5mg every 2-6 hours prn)

Question 6

AOP – Caffeine Citrate (CAFCIT)
Loading
Maintenance

Therapeutic Levels

Answer 6

loading dose – 20-25mg/kg IV or PO
Maintenance dose – 5-10 mg/kg/day IV or PO every 24 hours – to start 24 hours after the loading dose.

Therapeutic levels – (5-25mcg/ml trough) draw trough on day 5 of life if needed

Question 7

SEPSIS
Ampicillin
< 2 kg
> 2 kg

GBS meningitis

Answer 7

< 2kg=100mg/kg/day IV divided every 12 hours (meningitic dose but used most often in-house)
May see 50mg/kg/day IV divided every 12 hours

> 2 kg = divided every 8 hours (75-150mg/kg/day)

GBS meningitis- (200-300mg/kg/day divided every 8 hours IV

Question 8

Sepsis Gentamicin

= 29 weeks PMA

Answer 8

4-5mg/kg/dose every 36-48 hours (5mg and 48 hours if in first 7 days of life)

Question 9

Sepsis Gentamicin

30-34 weeks PMA

Answer 9

4-4.5mg/kg/dose every 24-36 hours (4.5 and 36hrs if in first 7 days of life)

Question 10

Sepsis Gentamicin

>/=35 weeks PMA

Answer 10

4mg/kg/dose IV every 24 hours

Question 11

Peak and Trough for Gentamicin

Answer 11

Peak 4-12 mcg

Trough 0.5-2 mcg

Question 12

Sepsis Vancomycin

MRSA DOSING

Answer 12

15 mg/kg/day IV every 8 (> 2kg and > 7 days) – 24hours -based on age and weight

MRSA DOSING- 15mg/kg/dose every 6 hours for 2-6 weeks

Question 13

Sepsis Cefotaxime

Answer 13

100mg/kg/day divided every 12 hours (up to 1month of age) IV

Question 14

Clindamycin (NEC)

Answer 14

10-15 mg/kg/day IV divided every 8-12 hours

Question 15

Zantac Ranitidine

Neonatal vs. Infant

Answer 15

Neonatal- (2-4mg/kg/day) divided every 8-12 hours po (max is 6mg/kg/day)

Infants > 1 month –(5-10mg/kg/day) divided 2-3 times daily