Nelson #3

Question 1

AL amyloid

Answer 1

“Amyloid light chain amyloid.” Either complete or fragmented immunoglobulin light chains. Usually lambda protein and not kappa.

Question 2

AA amyloid

Answer 2

“Amyloid -associated Amyloid.” derived by proteolysis of serum protein SAA (serum amyloid-associated protein) that is made in the liver and circulates the serum with HDL. Production is increased with inflammation so this form of amyloidosis is associated with CHRONIC INFLAMMATION.

Question 3

Beta-amyloid protein

Answer 3

derived by proteolysis of amyloid precursors protein. found in Alzheimer’s disease.

Question 4

Transthyretin (TTR)

Answer 4

normal serum protein, binds/transports thyroxine and retinol. If mutated TTR, result is ayloid deposition. Heritable neuropathic or cardiomyopathic amyloidosis.

Question 5

Beta2-microglobulin

Answer 5

normal serum protein that accumulates in patients on long term dialysis–>Condition called Hemodialysis-associated amyloidosis