neisseria meningitidis Flashcards
n.mening is a
gram negative diplococci
ferments what?
( whiskey bottle)
maltose
has what type of capsule? and this prevents what
polysaccharide and phagocytosis
which causes most of the disease in the US
serotype B
which has a poor imunogenic
(bourbin in capsule)
serotype B
Expreses what protease
(torn ace card)
IgA protease
what is the function of IgA protease
cleave IgA
what toxin does this produce
( lost flame)
LOS endotoxin
what is the LOS compound function
pro-inflamatory compound
what proteins does this batceria have
PorA and PorB
what are the functions of porin proteins
control diffusion and interacting with host cells
what binding protein is present
Transferrin binding protein
does this bacteria have a pili?
yes
what is the function of the pili
attachment to host cells and transfer genetic material and motility
how is it spread
(man sweating)
respiratory droplets
What are the 4 diseases associated with this bacteria
(rolled dice)
meningitist
sepsis
DIC
Waterhouse- Friderichsen syndrome
what is DIC
endotoxic shock
what is Waterhouse- Friderichsen syndrome
shock with bilateral hemorrhagic destruction of the adrenal glands `
what is the port of entry
nasopharynx
the bacteria attaches to
cd40 on nonciliated epithelium
when is the peak incidence of IMD
6-24 months
what type of vaccines
tetravalent conjugated capsular vaccines
what are two treatments
penicillin and ceftriaxone
