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Unit 5: Micro > Neisseria > Flashcards

Neisseria Flashcards

1
Q

Are all Neisseria pathogenic?

A

No

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2
Q

What makes certain Neisseria pathogenic?

A

Presence of virulence factors

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3
Q

What are the common Neisseria virulence factors between meningococcous and gonococcus?

A

LOS and IgA protease

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4
Q

What virulence factor is specific to Neisseria meningococcus

A

Capsule

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5
Q

What virulence factors are specific to Neisseria gonococcus?

A

Pili, porins, Opa (opacity proteins)

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6
Q

Classify Neisseria

A

Gram negative diplococcic that are facultative intracellular and aerobic

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7
Q

Do Neisseria only live in humans?

A

Yes

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8
Q

Are Neisseria oxidase positive or negative? Catalase positive or negative?

A

Oxidase positive and catalase positive

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9
Q

What does meningitidis ferment?

A

Maltose

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10
Q

Can you grow Neisseria on blood agar?

A

No, growth is inhibited

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11
Q

What’s the problem with growing Neisseria on nonselective media?

A

Overgrowth by normal flora makes it hard to analyze

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12
Q

If using Neisseria samples from mucous membranes what media should you use to culture the sample?

A

Thayer-Martin (for genital, nasopharyngeal)

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13
Q

If using Neisseria samples from normally sterile sites what media should you use to culture the sample?

A

Chocolate agar (CSF, blood)

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14
Q

How does the host defend against Neisseria? Is it effective?

A

IgG enhanced complement and PMNs. Effective against meningococcus and contains gonococcus

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15
Q

What if you’re complement deficient?

A

You are predisposed to complications

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16
Q

What is a complication of asymptomatic/untreated gonococcus in women?

A

PID

17
Q

What are potential serious complications of disseminated gonococcal infection (DGI)/ meningococcemia?

A

Septic arthritis, meningitis, endocarditis

18
Q

Are meningitidis cases sporadic or usually an outbreak? What about gonorrhea?

A

Meningitidis can be sporadic or an outbreak. Gonorrhea is common

19
Q

Are neonates protected from meningococcus?

A

Yes, passively from mom

20
Q

Are neonates protected from gonococcus?

A

They are given prophylactic eye ointment for protection

21
Q

What kind of testing should be done?

A

Test with culture and gram stain appropriate samples. DNA testing is available

22
Q

How can you prevent meningococcus?

A

Vaccine

23
Q

How can you prevent gonococcus?

A

Condoms

24
Q

How do you treat the Neisseria?

A

Ceftriaxone and cefixime. Admit if complicated

Unit 5: Micro (3 decks)

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