Needlestick transmission of blood-borne viruses Flashcards
How to prevent Hep B infection from needlestick in HCW
Vaccination of non-responders or non-vaccinated
PEP - vaccination or HBIg
How to prevent Hep B infection from needlestick in HCW
Vaccination of non-responders or non-vaccinated
PEP - vaccination or HBIg
What type of Hep B positive patient is the most infectious?
HepB E Ag positive.
Reduced risk if Anti-E positive and low levels of HBV DNA
What does a HBV vaccination consist of?
Purified surface Ag
Requires x 3 doses
What is the definition of a non-response to HBV vaccination? What are its implications?
How many adults are HBV vaccination non-responders?
5-10%
What type of Hep B positive patient is the most infectious?
HepB E Ag positive.
Reduced risk if Anti-E positive and low levels of HBV DNA
What does a HBV vaccination consist of?
Purified surface Ag
Requires x 3 doses
What should the response be to Hep B vaccination?
Generation of anti- HBs
What is the definition of a non-response to HBV vaccination? What are its implications?
0-10 iu
No hep b protection
How many adults are HBV vaccination non-responders?
5-10%
What is the definition of a hypo-response/sub-optimal responders to HBV vaccination? What are its implications?
10-100 iu/l 6-10 weeks after completion of vaccination schedule.
? protected against HBV infection or not
USA and Europe consider protective.
‘Seroconversion’
How many adults are HBV vaccination sub-optimal responders?
5-10% adults
What is the definition of an optimal response to HBV vaccination? What are its implications?
> 100 iu/l 6-10 weeks after completion of 3-dose vaccination schedule
Protected against HBV infection
‘Seroprotection’
What can be done to increase protection of HBV vaccination non-responders?
Repeat course of vaccine and re-test anti-HBs (Complete course of 6)